Role of dietary intake of specific polyunsaturated fatty acids (PUFAs) on colorectal cancer risk in Iran.
colon cancer
colorectal cancer
diet
free fatty acids
polyunsaturated fatty acids
Journal
Lipids
ISSN: 1558-9307
Titre abrégé: Lipids
Pays: United States
ID NLM: 0060450
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
03
01
2024
received:
01
09
2023
accepted:
07
01
2024
medline:
12
3
2024
pubmed:
30
1
2024
entrez:
30
1
2024
Statut:
ppublish
Résumé
High-fat diets have been associated with colorectal cancer (CRC) risk, and the role of polyunsaturated fatty acids (PUFAs) has been reported to vary based on the length of PUFAs. We explored the association between dietary omega-6 and omega-3 PUFAs intake and CRC. We analyzed 865 CRC patients and 3206 controls from a case-control study of Iran (IROPICAN study). We used multivariate logistic regression models to calculate the odds ratios (OR) and 95% confidence intervals (CI) for the association between PUFAs intake and CRC risk. Our results showed that gamma-linolenic acid (18:3 n-6, GLA), arachidonic acid (20:4n-6, ARA), a-linolenic acid (Cis-18:3n-3, ALA), eicosapentaenoic acid (20:5n-3, EPA), docosahexaenoic acid (22:6n-3, DHA) consumption was not associated with the risk of CRC. However, the OR of linoleic acid (18: 2n-6, LA) intake was 1.47 (95% CI 1.01-2.14, p = 0.04) for proximal colon and that of docosapentaenoic acid (22:5n-3, DPA) intake was 1.33 (95% CI 1.05-1.69, p = 0.01) for rectum. This study indicates a high level of LA is associated with an increased risk of proximal colon cancer, and DPA intake was positively associated with rectum cancer risk. Furthermore, our study noted a high intake of n-6 (from vegetable oils) compared to n-3 PUFAs (from fish and seafood) in this population. Public awareness and government support is needed to increase fish and seafood production and consumption in Iran.
Substances chimiques
Fatty Acids, Unsaturated
0
Fatty Acids, Omega-3
0
Eicosapentaenoic Acid
AAN7QOV9EA
Docosahexaenoic Acids
25167-62-8
Linoleic Acid
9KJL21T0QJ
gamma-Linolenic Acid
78YC2MAX4O
Fatty Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-53Subventions
Organisme : World Health Organization
ID : 001
Pays : International
Informations de copyright
© 2024 AOCS.
Références
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