How intrinsically disordered proteins order plant gene silencing.
gene silencing
intrinsically disordered protein (IDP)
intrinsically disordered region (IDR)
liquid–liquid phase separation
miRNA
siRNA
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
03 2024
03 2024
Historique:
received:
02
10
2023
revised:
25
12
2023
accepted:
29
12
2023
pmc-release:
01
03
2025
medline:
7
3
2024
pubmed:
1
2
2024
entrez:
31
1
2024
Statut:
ppublish
Résumé
Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) possess low sequence complexity of amino acids and display non-globular tertiary structures. They can act as scaffolds, form regulatory hubs, or trigger biomolecular condensation to control diverse aspects of biology. Emerging evidence has recently implicated critical roles of IDPs and IDR-contained proteins in nuclear transcription and cytoplasmic post-transcriptional processes, among other molecular functions. We here summarize the concepts and organizing principles of IDPs. We then illustrate recent progress in understanding the roles of key IDPs in machineries that regulate transcriptional and post-transcriptional gene silencing (PTGS) in plants, aiming at highlighting new modes of action of IDPs in controlling biological processes.
Identifiants
pubmed: 38296708
pii: S0168-9525(23)00284-6
doi: 10.1016/j.tig.2023.12.009
pmc: PMC10932933
mid: NIHMS1956500
pii:
doi:
Substances chimiques
Intrinsically Disordered Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
260-275Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM127742
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM151976
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no conflicts of interests.
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