Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia.

Metabolomics Physiology Transcriptomics

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
16 Feb 2024
Historique:
received: 21 09 2023
revised: 21 11 2023
accepted: 16 01 2024
medline: 9 2 2024
pubmed: 9 2 2024
entrez: 9 2 2024
Statut: epublish

Résumé

A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In the liver, genes associated with inflammation and fatty acid metabolism were altered within 1 month of HGI diet, whereas 12-month HGI diet-fed group showed dysregulated expression of cytochrome P450 genes and overexpression of lipogenic factors including

Identifiants

DOI: 10.1016/j.isci.2024.108979 PMID: 38333717 PMC: PMC10850775
pubmed: 38333717
doi: 10.1016/j.isci.2024.108979
pii: S2589-0042(24)00200-1
pmc: PMC10850775
doi:

Types de publication

Journal Article

Langues

eng

Pagination

108979

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Anupam K Mondal (AK)

Neurobiology Neurodegeneration & Repair Laboratory, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.

Daniel C Brock (DC)

Neurobiology Neurodegeneration & Repair Laboratory, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.

Sheldon Rowan (S)

Laboratory for Nutrition & Vision Research, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Friedman School of Nutrition Science and Policy, and Department of Molecular and Chemical Biology, Tufts University, Boston, MA, USA.
Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA.

Zhi-Hong Yang (ZH)

Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.

Krishna Vamsi Rojulpote (KV)

Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.

Kelsey M Smith (KM)

Laboratory for Nutrition & Vision Research, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Friedman School of Nutrition Science and Policy, and Department of Molecular and Chemical Biology, Tufts University, Boston, MA, USA.

Sarah G Francisco (SG)

Laboratory for Nutrition & Vision Research, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.

Eloy Bejarano (E)

Laboratory for Nutrition & Vision Research, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
School of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Valencia, Spain.

Milton A English (MA)

Neurobiology Neurodegeneration & Repair Laboratory, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.

Amy Deik (A)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Sarah Jeanfavre (S)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Clary B Clish (CB)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Alan T Remaley (AT)

Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.

Allen Taylor (A)

Laboratory for Nutrition & Vision Research, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Friedman School of Nutrition Science and Policy, and Department of Molecular and Chemical Biology, Tufts University, Boston, MA, USA.
Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA.

Anand Swaroop (A)

Neurobiology Neurodegeneration & Repair Laboratory, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.

Classifications MeSH