Crosstalk between protein post-translational modifications and phase separation.
Biomolecular condensates
Neurodegenerative Diseases
Phase separation
Post-translational modifications
Tumors
Viral Infections
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
12 02 2024
12 02 2024
Historique:
received:
15
09
2023
accepted:
02
11
2023
medline:
13
2
2024
pubmed:
13
2
2024
entrez:
12
2
2024
Statut:
epublish
Résumé
The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current research on the correlation between protein modifications and phase separation and the interference with the tendency of phase separation has some limitations. Here we focus on several post-translational modifications of proteins, including protein phosphorylation modification at multiple sites, methylation modification, acetylation modification, ubiquitination modification, SUMOylation modification, etc., which regulate the formation of phase separation and the stability of phase separation structure through multivalent interactions. This regulatory role is closely related to the development of neurodegenerative diseases, tumors, viral infections, and other diseases, and also plays essential functions in environmental stress, DNA damage repair, transcriptional regulation, signal transduction, and cell homeostasis of living organisms, which provides an idea to explore the interaction between novel protein post-translational modifications and phase separation. Video Abstract.
Identifiants
pubmed: 38347544
doi: 10.1186/s12964-023-01380-1
pii: 10.1186/s12964-023-01380-1
pmc: PMC10860296
doi:
Substances chimiques
Proteins
0
Types de publication
Video-Audio Media
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110Subventions
Organisme : the National Natural Science Foundation of China
ID : 82271643
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2020MH061
Organisme : Jinan Science and Technology Development Plan
ID : 202134060
Informations de copyright
© 2024. The Author(s).
Références
Nature. 2012 Mar 07;483(7389):336-40
pubmed: 22398450
Acta Biochim Biophys Sin (Shanghai). 2021 Nov 10;53(11):1527-1537
pubmed: 34490876
Acta Neuropathol. 2020 Feb;139(2):407-410
pubmed: 31832771
Cell. 2018 Sep 6;174(6):1492-1506.e22
pubmed: 30173914
Cell Res. 2018 Apr;28(4):405-415
pubmed: 29507397
Yi Chuan. 2013 Jan;35(1):17-26
pubmed: 23357261
Mol Cell. 2015 Oct 15;60(2):231-41
pubmed: 26455390
Nat Rev Mol Cell Biol. 2012 Jun 20;13(7):411-24
pubmed: 22713970
J Proteomics. 2016 Feb 16;134:57-64
pubmed: 26254007
J Am Chem Soc. 2021 Aug 18;143(32):12675-12687
pubmed: 34346674
Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201483119
pubmed: 35930668
Mol Cell. 2015 Mar 5;57(5):936-947
pubmed: 25747659
J Mol Cell Biol. 2022 May 20;14(2):
pubmed: 35040963
Genome Biol. 2002;3(5):reviews0006
pubmed: 12049668
Angew Chem Int Ed Engl. 2021 Jan 11;60(2):726-730
pubmed: 33017094
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7189-94
pubmed: 26015579
iScience. 2021 Oct 14;24(11):103268
pubmed: 34761188
Mol Cell. 2022 Oct 6;82(19):3693-3711.e10
pubmed: 36108633
Cell Discov. 2023 May 9;9(1):47
pubmed: 37156794
Nat Chem Biol. 2019 Jan;15(1):51-61
pubmed: 30531905
J Biol Chem. 2017 Sep 15;292(37):15277-15286
pubmed: 28760828
Nat Rev Mol Cell Biol. 2015 Jan;16(1):30-44
pubmed: 25531226
J Chem Inf Model. 2022 Jul 11;62(13):3227-3238
pubmed: 35709363
EMBO Rep. 2022 Jul 5;23(7):e53855
pubmed: 35642598
J Biol Chem. 2010 Dec 17;285(51):39779-89
pubmed: 20947499
EMBO J. 2022 Apr 19;41(8):e108443
pubmed: 35112738
J Biol Chem. 2012 May 11;287(20):16088-102
pubmed: 22433848
Mol Cell. 2022 Apr 7;82(7):1313-1328.e8
pubmed: 35325613
Nat Cell Biol. 2022 Apr;24(4):513-525
pubmed: 35393539
J Phys Chem B. 2012 Mar 29;116(12):3874-9
pubmed: 22376228
Nat Commun. 2022 Mar 9;13(1):1223
pubmed: 35264561
J Neurosci. 2014 Jun 4;34(23):7802-13
pubmed: 24899704
Proc Natl Acad Sci U S A. 2005 May 24;102(21):7635-40
pubmed: 15897469
EMBO J. 2018 Apr 3;37(7):
pubmed: 29472250
Nat Struct Mol Biol. 2020 Apr;27(4):333-341
pubmed: 32203489
Nucleic Acids Res. 2022 Oct 28;50(19):11273-11284
pubmed: 36259663
Biochem Pharmacol. 2019 Sep;167:58-63
pubmed: 31034795
Biochim Biophys Acta Gene Regul Mech. 2022 May;1865(4):194827
pubmed: 35618207
Int J Biol Macromol. 2022 Mar 15;201:173-181
pubmed: 35016968
Cell Rep. 2021 Jun 22;35(12):109277
pubmed: 34161763
Nat Chem Biol. 2023 Oct;19(10):1223-1234
pubmed: 37400539
Nat Rev Mol Cell Biol. 2017 May;18(5):285-298
pubmed: 28225081
Nature. 2017 Jul 13;547(7662):236-240
pubmed: 28636604
Acta Biochim Biophys Sin (Shanghai). 2023 Jul 21;55(7):1133-1152
pubmed: 37475546
Mol Cell. 2018 Oct 4;72(1):19-36.e8
pubmed: 30244836
Nat Commun. 2015 Jan 05;6:5845
pubmed: 25556531
Mol Syst Biol. 2014 Jan 30;10:716
pubmed: 24489116
EMBO J. 2021 Feb 1;40(3):e105001
pubmed: 33349959
Cell. 2019 Oct 3;179(2):470-484.e21
pubmed: 31543265
Nat Commun. 2021 May 24;12(1):3057
pubmed: 34031393
Int J Mol Sci. 2023 Mar 30;24(7):
pubmed: 37047451
Bioorg Chem. 2023 Mar;132:106347
pubmed: 36630781
J Virol. 2019 Oct 15;93(21):
pubmed: 31375591
Sci China Life Sci. 2020 Jul;63(7):953-985
pubmed: 32548680
Autophagy. 2022 Aug;18(8):2013-2015
pubmed: 35438056
Biochem J. 2019 May 21;476(10):1401-1417
pubmed: 31036717
Emerg Top Life Sci. 2020 Dec 11;4(3):307-318
pubmed: 32364240
Science. 2009 Jun 26;324(5935):1729-32
pubmed: 19460965
Nat Immunol. 2022 Aug;23(8):1193-1207
pubmed: 35879450
Front Mol Biosci. 2021 Oct 19;8:689687
pubmed: 34738012
J Cell Sci. 2017 Sep 1;130(17):2789-2796
pubmed: 28808090
Cell. 2009 Feb 20;136(4):731-45
pubmed: 19239892
Biochem Biophys Res Commun. 2017 Jan 22;482(4):632-637
pubmed: 27864145
Front Physiol. 2022 Mar 01;13:827435
pubmed: 35586714
J Biol Chem. 2006 May 5;281(18):12664-72
pubmed: 16524876
Mol Cell. 2020 Dec 17;80(6):1092-1103.e4
pubmed: 33248025
Biochim Biophys Acta Mol Cell Res. 2021 Oct;1868(11):119102
pubmed: 34293345
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8194-E8203
pubmed: 28894006
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4218-4227
pubmed: 30765518
J Biol Chem. 2022 Dec;298(12):102631
pubmed: 36273579
Soft Matter. 2022 Nov 16;18(44):8406-8417
pubmed: 36285640
BMB Rep. 2022 Aug;55(8):363-369
pubmed: 35880435
Cell. 2018 Apr 19;173(3):720-734.e15
pubmed: 29677515
Rep Prog Phys. 2018 Apr;81(4):046601
pubmed: 29313527
Cell. 2012 May 11;149(4):753-67
pubmed: 22579281
EMBO J. 2017 Oct 16;36(20):2951-2967
pubmed: 28790177
PLoS Comput Biol. 2021 May 4;17(5):e1008939
pubmed: 33945530
Nature. 2020 Mar;579(7800):592-597
pubmed: 32214243
Bioessays. 2016 Oct;38(10):959-68
pubmed: 27554449
Annu Rev Cell Dev Biol. 2014;30:39-58
pubmed: 25288112
Cell. 2018 Jul 26;174(3):688-699.e16
pubmed: 29961577
J Craniofac Surg. 2019 May/Jun;30(3):784-789
pubmed: 30896514
Cell. 2018 Apr 19;173(3):706-719.e13
pubmed: 29677514
Nature. 2010 Sep 23;467(7314):470-3
pubmed: 20835226
Nat Chem. 2022 Jul;14(7):831-840
pubmed: 35637289
Mol Cell. 2018 Feb 1;69(3):465-479.e7
pubmed: 29358076
Cell. 2012 May 11;149(4):768-79
pubmed: 22579282
Genome Biol. 2022 Sep 12;23(1):192
pubmed: 36096799
Mol Biol Cell. 2018 Aug 1;29(15):1786-1797
pubmed: 29897835
Cell Res. 2019 Mar;29(3):233-247
pubmed: 30728452
Cell Commun Signal. 2016 Jan 05;14:1
pubmed: 26727894
Cell. 2017 Oct 19;171(3):615-627.e16
pubmed: 28942918
Int J Mol Sci. 2021 Jun 22;22(13):
pubmed: 34206440
Protein Sci. 2023 Apr;32(4):e4618
pubmed: 36883310
Nucleic Acids Res. 2022 Dec 9;50(22):12702-12722
pubmed: 36537242
Protein Cell. 2020 Mar;11(3):202-207
pubmed: 31894537
Nat Cell Biol. 2020 Apr;22(4):453-464
pubmed: 32203417
Elife. 2022 Feb 22;11:
pubmed: 35191833
Mol Cell Biol. 2016 Aug 12;36(17):2226-35
pubmed: 27247266
JACS Au. 2022 Dec 30;3(1):93-104
pubmed: 36711093
Nat Chem. 2016 Feb;8(2):129-37
pubmed: 26791895
Adv Enzymol Relat Areas Mol Biol. 1975;42:227-86
pubmed: 1093364
Int J Mol Sci. 2018 May 04;19(5):
pubmed: 29734651
Cell Mol Life Sci. 2022 Jun 24;79(7):380
pubmed: 35750966
Mol Cell. 2023 May 18;83(10):1640-1658.e9
pubmed: 37059091
Nat Commun. 2021 Jun 9;12(1):3497
pubmed: 34108453
Nat Chem Biol. 2023 Nov;19(11):1372-1383
pubmed: 37592155
FEMS Yeast Res. 2018 Aug 1;18(5):
pubmed: 29788207
Angew Chem Int Ed Engl. 2020 Mar 2;59(10):4059-4067
pubmed: 31863676
Nat Rev Cancer. 2014 Jul;14(7):502-9
pubmed: 24898058
Int J Mol Sci. 2019 Nov 05;20(21):
pubmed: 31694155
Protein Sci. 2021 Jul;30(7):1337-1349
pubmed: 33547841
FEBS Lett. 1997 Nov 17;417(3):297-300
pubmed: 9409737
EMBO J. 2018 Mar 1;37(5):
pubmed: 29438978
Sci Rep. 2020 May 19;10(1):8286
pubmed: 32427867
PLoS One. 2022 Aug 5;17(8):e0272700
pubmed: 35930602
Nat Commun. 2021 Apr 9;12(1):2114
pubmed: 33837182
Nature. 2018 Jun;558(7709):318-323
pubmed: 29849146
J Mol Biol. 2020 Jan 17;432(2):467-483
pubmed: 31805282
Biochemistry. 2021 Aug 10;60(31):2397-2406
pubmed: 34291921
Trends Biochem Sci. 2010 Apr;35(4):208-19
pubmed: 20106667
Angew Chem Int Ed Engl. 2023 Nov 20;62(47):e202311190
pubmed: 37779326
Nat Struct Mol Biol. 2020 Apr;27(4):363-372
pubmed: 32231288
J Cell Biol. 2021 Apr 5;220(4):
pubmed: 33651074
Nat Commun. 2021 Dec 15;12(1):7289
pubmed: 34911929
Nat Commun. 2017 Aug 17;8(1):275
pubmed: 28819146
RNA Biol. 2012 May;9(5):610-23
pubmed: 22614839
Neuron. 2019 Oct 23;104(2):290-304.e8
pubmed: 31378567