NPFs-mediated actin cytoskeleton: a new viewpoint on autophagy regulation.
Actin cytoskeleton
Autophagic lysosome reformation
Autophagosome formation
Autophagy
Nucleation-promoting factors
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
12 02 2024
12 02 2024
Historique:
received:
25
10
2023
accepted:
18
12
2023
medline:
14
2
2024
pubmed:
13
2
2024
entrez:
12
2
2024
Statut:
epublish
Résumé
Macroautophagy/autophagy is a lysosome-dependent catabolic process induced by various cellular stress conditions, maintaining the homeostasis of cells, tissues and organs. Autophagy is a series of membrane-related events involving multiple autophagy-related (ATG) proteins. Most studies to date have focused on various signaling pathways affecting ATG proteins to control autophagy. However, mounting evidence reveals that the actin cytoskeleton acts on autophagy-associated membranes to regulate different events of autophagy. The actin cytoskeleton assists in vesicle formation and provides the mechanical forces for cellular activities that involve membrane deformation. Although the interaction between the actin cytoskeleton and membrane makes the role of actin in autophagy recognized, how the actin cytoskeleton is recruited and assembles on membranes during autophagy needs to be detailed. Nucleation-promoting factors (NPFs) activate the Arp2/3 complex to produce actin cytoskeleton. In this review, we summarize the important roles of the actin cytoskeleton in autophagy regulation and focus on the effect of NPFs on actin cytoskeleton assembly during autophagy, providing new insights into the occurrence and regulatory mechanisms of autophagy. Video Abstract.
Identifiants
pubmed: 38347641
doi: 10.1186/s12964-023-01444-2
pii: 10.1186/s12964-023-01444-2
pmc: PMC10860245
doi:
Substances chimiques
Actins
0
Actin-Related Protein 2-3 Complex
0
Types de publication
Video-Audio Media
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111Subventions
Organisme : National Natural Science Foundation of China
ID : 82072935
Organisme : Department of Science and Technology of Jilin Province
ID : 20220402083GH
Informations de copyright
© 2024. The Author(s).
Références
Genes Dev. 2007 Nov 15;21(22):2861-73
pubmed: 18006683
EMBO J. 1996 Oct 1;15(19):5326-35
pubmed: 8895577
Chin J Cancer. 2017 Jun 24;36(1):52
pubmed: 28646911
Mol Biol Cell. 2008 May;19(5):1962-75
pubmed: 18287533
Int J Biochem Cell Biol. 2004 Dec;36(12):2420-34
pubmed: 15325582
Trends Cell Biol. 2010 Nov;20(11):650-61
pubmed: 20888769
Annu Rev Genet. 2009;43:67-93
pubmed: 19653858
FEBS Lett. 2007 Jul 24;581(18):3396-404
pubmed: 17618624
Nat Commun. 2018 Jul 20;9(1):2855
pubmed: 30030437
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
J Exp Biol. 2003 Jun;206(Pt 12):1977-84
pubmed: 12756279
Physiol Rev. 2014 Jan;94(1):235-63
pubmed: 24382887
Mol Biol Cell. 2013 Sep;24(17):2714-26
pubmed: 23885127
Trends Cell Biol. 2012 Jan;22(1):1-13
pubmed: 22018597
Cell. 2008 Jul 11;134(1):148-61
pubmed: 18614018
Nat Cell Biol. 2015 Sep;17(9):1112-23
pubmed: 26237647
Nat Cell Biol. 2009 Apr;11(4):451-9
pubmed: 19287377
Science. 2010 Dec 3;330(6009):1344-8
pubmed: 21127245
Curr Biol. 2012 Jan 10;22(1):R29-34
pubmed: 22240478
Cells. 2021 Nov 10;10(11):
pubmed: 34831341
FEBS Lett. 2010 Apr 2;584(7):1302-12
pubmed: 20074568
Science. 2016 Nov 25;354(6315):1036-1041
pubmed: 27885029
Nature. 2015 Apr 23;520(7548):563-6
pubmed: 25686604
Nat Commun. 2014 May 13;5:3828
pubmed: 24819384
J Exp Clin Cancer Res. 2023 Mar 20;42(1):68
pubmed: 36935496
Nat Cell Biol. 2009 Dec;11(12):1433-7
pubmed: 19898463
Trends Cell Biol. 2007 Nov;17(11):555-62
pubmed: 17949983
Nat Commun. 2019 Aug 16;10(1):3699
pubmed: 31420534
Nat Struct Mol Biol. 2020 Jun;27(6):570-580
pubmed: 32424346
Trends Cell Biol. 2022 May;32(5):421-432
pubmed: 34836783
Autophagy. 2012 Nov;8(11):1590-603
pubmed: 22863730
Dev Cell. 2009 Nov;17(5):699-711
pubmed: 19922874
EMBO J. 2013 Oct 16;32(20):2685-96
pubmed: 23974797
Biochem Biophys Res Commun. 2013 Aug 2;437(3):482-8
pubmed: 23850690
Mol Cell. 2014 Jul 17;55(2):238-52
pubmed: 24954904
Physiol Rev. 2018 Jan 1;98(1):215-238
pubmed: 29212790
Biochem Biophys Rep. 2016 Nov 09;9:13-21
pubmed: 28955984
Cell Res. 2014 Aug;24(8):943-58
pubmed: 24980959
Nat Cell Biol. 2011 Feb;13(2):132-41
pubmed: 21258367
Nat Cell Biol. 2011 Dec 22;14(1):11-9
pubmed: 22193159
Heliyon. 2023 Jan 07;9(1):e12820
pubmed: 36691538
Nat Cell Biol. 2012 Sep;14(9):924-34
pubmed: 22885770
Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364
pubmed: 29618831
J Cell Biol. 2008 Aug 25;182(4):685-701
pubmed: 18725538
Cell Signal. 2020 Mar;67:109505
pubmed: 31857241
Autophagy. 2009 Nov;5(8):1180-5
pubmed: 19855179
EMBO Rep. 2008 Sep;9(9):859-64
pubmed: 18704115
Curr Opin Cell Biol. 2006 Feb;18(1):4-10
pubmed: 16343889
Nature. 2000 Nov 23;408(6811):488-92
pubmed: 11100732
Autophagy. 2016 Dec;12(12):2512-2515
pubmed: 27723370
Nat Rev Mol Cell Biol. 2013 Jan;14(1):7-12
pubmed: 23212475
J Cell Biol. 2006 Dec 18;175(6):925-35
pubmed: 17178909
Trends Cell Biol. 2009 Jun;19(6):276-85
pubmed: 19406642
Cell Death Differ. 2005 Nov;12 Suppl 2:1542-52
pubmed: 16247502
EMBO J. 2016 Sep 1;35(17):1853-67
pubmed: 27340123
Trends Biochem Sci. 2017 Jun;42(6):414-430
pubmed: 28372857
Trends Cell Biol. 2018 Feb;28(2):79-98
pubmed: 29162307
Structure. 2008 May;16(5):695-704
pubmed: 18462674
J Cell Physiol. 1992 Sep;152(3):458-66
pubmed: 1506410
Curr Biol. 2001 Mar 6;11(5):370-4
pubmed: 11267876
Mol Cell. 2016 Sep 1;63(5):781-95
pubmed: 27588602
Nat Rev Immunol. 2012 Jun 15;12(7):492-502
pubmed: 22699831
J Cell Biol. 2013 Oct 28;203(2):315-26
pubmed: 24145164
Traffic. 2017 Jun;18(6):358-361
pubmed: 28371052
Dev Cell. 2011 Apr 19;20(4):444-54
pubmed: 21497758
J Pathol. 2010 May;221(1):3-12
pubmed: 20225336
Traffic. 2005 Jan;6(1):56-65
pubmed: 15569245
Elife. 2020 Nov 02;9:
pubmed: 33135633
Autophagy. 2018;14(2):207-215
pubmed: 28933638
Curr Biol. 2015 Jun 29;25(13):1791-7
pubmed: 26096974
Autophagy. 2010 May;6(4):506-22
pubmed: 20505359
EMBO J. 2010 Jun 2;29(11):1792-802
pubmed: 20418806
Protoplasma. 2021 Jul;258(4):683-693
pubmed: 33471226
Nat Struct Mol Biol. 2014 Apr;21(4):336-45
pubmed: 24699082
Antioxid Redox Signal. 2014 Jan 20;20(3):460-73
pubmed: 23725295
Mol Cancer. 2020 Jan 22;19(1):12
pubmed: 31969156
Mol Biol Cell. 2005 Dec;16(12):5843-56
pubmed: 16221887
Nat Cell Biol. 2017 Aug;19(8):876-882
pubmed: 28714972
Nat Commun. 2017 Nov 17;8(1):1576
pubmed: 29146903
Signal Transduct Target Ther. 2021 Feb 23;6(1):76
pubmed: 33619246
Cytoskeleton (Hoboken). 2010 Mar;67(3):193-206
pubmed: 20175130
J Mol Biol. 2006 Jun 16;359(4):840-7
pubmed: 16697006
Oncogene. 2011 Dec 1;30(48):4835-42
pubmed: 21625218
Cell. 2012 Dec 7;151(6):1256-69
pubmed: 23217709
Mol Cell. 1999 Sep;4(3):365-76
pubmed: 10518217
Traffic. 2008 Apr;9(4):574-87
pubmed: 18182013
Eur J Cell Biol. 2014 May-Jun;93(5-6):194-204
pubmed: 25015719
Nat Commun. 2015 Aug 20;6:8045
pubmed: 26289944
J Cell Biol. 2019 Jan 7;218(1):251-266
pubmed: 30420355
Essays Biochem. 2019 Oct 31;63(5):483-495
pubmed: 31551324
Autophagy. 2011 Jul;7(7):673-82
pubmed: 21646866
J Cell Biol. 2012 Jul 23;198(2):219-33
pubmed: 22826123
Nat Cell Biol. 2013 Jul;15(7):741-50
pubmed: 23685627
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7826-31
pubmed: 21518918
Dev Cell. 2016 May 23;37(4):326-336
pubmed: 27219061
Curr Biol. 2001 Jan 23;11(2):130-5
pubmed: 11231131
Autophagy. 2020 May;16(5):826-841
pubmed: 31366282
Mol Biol Cell. 2008 May;19(5):2092-100
pubmed: 18321988
Cell Mol Life Sci. 2016 Sep;73(17):3249-63
pubmed: 27147468
Int J Oncol. 2016 Jun;48(6):2647-56
pubmed: 27035872
Biochemistry (Mosc). 2014 Sep;79(9):917-27
pubmed: 25385019
Cell Adh Migr. 2011 Mar-Apr;5(2):187-98
pubmed: 21258212
Mol Biol Cell. 2009 Apr;20(7):1992-2003
pubmed: 19225151
Nat Commun. 2015 Jul 30;6:7888
pubmed: 26223951
J Cell Biol. 2019 Mar 4;218(3):757-770
pubmed: 30578282
J Cell Sci. 2003 May 1;116(Pt 9):1679-88
pubmed: 12665549
Acta Pharm Sin B. 2020 Apr;10(4):569-581
pubmed: 32322463
Chem Biol. 2013 May 23;20(5):701-12
pubmed: 23623350
EMBO J. 2000 Nov 1;19(21):5720-8
pubmed: 11060023
Autophagy. 2022 Nov;18(11):2537-2546
pubmed: 35239457
Curr Biol. 2002 Aug 6;12(15):1270-8
pubmed: 12176354
Nat Rev Mol Cell Biol. 2010 Apr;11(4):237-51
pubmed: 20237478
Elife. 2013 Sep 03;2:e00884
pubmed: 24015358
J Cell Biol. 2001 Feb 19;152(4):657-68
pubmed: 11266458
Nat Commun. 2020 Dec 22;11(1):6437
pubmed: 33353942
EMBO J. 2010 Mar 3;29(5):969-80
pubmed: 20075865
Autophagy. 2023 Nov;19(11):2934-2957
pubmed: 37450577
Eur J Med Chem. 2023 Aug 5;256:115467
pubmed: 37178482
Autophagy. 2018;14(4):584-597
pubmed: 29313410
Traffic. 2016 Aug;17(8):878-90
pubmed: 27146966
Mol Biol Cell. 2009 Apr;20(7):1981-91
pubmed: 19211835
Autophagy. 2023 May;19(5):1378-1395
pubmed: 36409033