The role of the peripheral and central adrenergic system in the construction of the subjective emotional experience of panic.
Adrenergic beta-1 receptor
Blood pressure
Carbon dioxide
Emotions
Heart rate
Panic
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
22
11
2022
accepted:
29
01
2024
medline:
26
2
2024
pubmed:
16
2
2024
entrez:
16
2
2024
Statut:
ppublish
Résumé
Although the study of emotions can look back to over 100 years of research, it is unclear which information the brain uses to construct the subjective experience of an emotion. In the current study, we assess the role of the peripheral and central adrenergic system in this respect. Healthy volunteers underwent a double inhalation of 35% CO Heart rate and systolic blood pressure were reduced in both β-blocker conditions compared to placebo, showing effective inhibition of the adrenergic tone. Nevertheless, the subjective experience of the induced panic was the same in all conditions, as measured by self-reported fear, discomfort, and panic symptom ratings. These results indicate that information from the peripheral and central adrenergic system does not play a major role in the construction of the subjective emotion.
Identifiants
pubmed: 38363344
doi: 10.1007/s00213-024-06548-2
pii: 10.1007/s00213-024-06548-2
pmc: PMC10884065
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
627-635Informations de copyright
© 2024. The Author(s).
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