Signal Peptide Peptidase-Like 2b Modulates the Amyloidogenic Pathway and exhibits an Aβ-dependent expression in Alzheimer's Disease.

Alzheimer’s disease AppNL-G-F knock-in mice BRI2 SPPL2b amyloid β microglia

Journal

Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121

Informations de publication

Date de publication:
15 Feb 2024
Historique:
received: 30 06 2023
revised: 25 01 2024
accepted: 08 02 2024
medline: 18 2 2024
pubmed: 18 2 2024
entrez: 17 2 2024
Statut: aheadofprint

Résumé

Alzheimer's disease (AD) is a multifactorial disorder driven by abnormal amyloid β-peptide (Aβ) levels. In this study, we investigated the role of presenilin-like signal peptide peptidase-like 2b (SPPL2b) in AD pathophysiology and its potential as a druggable target within the Aβ cascade. Exogenous Aβ42 influenced SPPL2b expression in human cell lines and acute mouse brain slices. SPPL2b and its AD-related substrate BRI2 were evaluated in the brains of App

Identifiants

DOI: 10.1016/j.pneurobio.2024.102585 PMID: 38367747
pubmed: 38367747
pii: S0301-0082(24)00021-2
doi: 10.1016/j.pneurobio.2024.102585
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102585

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Conflict of interest The authors declare that they have no conflict of interest.

Auteurs

Riccardo Maccioni (R)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden; Department of Immunology and Microbiology, Scripps Research, La Jolla, California, 92037 United States. Electronic address: rmaccioni@scripps.edu.

Caterina Travisan (C)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden; Department of life science, University of Trieste, Trieste, 34127 Italy. Electronic address: caterina.travisan@kuleuven.be.

Jack Badman (J)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden. Electronic address: jack.lloyd.badman@ki.se.

Stefania Zerial (S)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden; Department of life science, University of Trieste, Trieste, 34127 Italy. Electronic address: stefania.zerial@gmail.com.

Annika Wagener (A)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden; Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, 69117 Germany. Electronic address: annika.wagener@mail03.med.uni-muenchen.de.

Yuniesky Andrade-Talavera (Y)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden. Electronic address: yandtal@upo.es.

Federico Picciau (F)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden; Department of Biomedical Sciences, Cytomorphology, University of Cagliari, Cagliari, 09042, Italy. Electronic address: federico.picciau@stud.ki.se.

Caterina Grassi (C)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126 Italy. Electronic address: caterinagrassi@gmail.com.

Gefei Chen (G)

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, 141 52 Sweden. Electronic address: gefei.chen@ki.se.

Laetitia Lemoine (L)

Department of Neurobiology, Care Sciences, and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, 141 52 Huddinge, Sweden. Electronic address: laetitia.lemoine@ki.se.

André Fisahn (A)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden. Electronic address: andre.fisahn@ki.se.

Richeng Jiang (R)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden; Department of Otolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Changchun, 3066, China. Electronic address: richeng.jiang@ki.se.

Regina Fluhrer (R)

Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, 86159 Germany. Electronic address: regina.fluhrer@med.uni-augsburg.de.

Torben Mentrup (T)

Institute of Physiological Chemistry, Technische Universität Dresden, Dresden, 01307 Germany. Electronic address: mentrup@msx.tu-dresden.de.

Bernd Schröder (B)

Institute of Physiological Chemistry, Technische Universität Dresden, Dresden, 01307 Germany. Electronic address: bernd.schroeder@tu-dresden.de.

Per Nilsson (P)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden. Electronic address: per.et.nilsson@ki.se.

Simone Tambaro (S)

Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 171 64, Solna, Sweden. Electronic address: simone.tambaro@ki.se.

Classifications MeSH