Regina Fluhrer

Affiliations

Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Publications (14)

Signaling Functions of Intramembrane Aspartyl-Proteases.

Frontiers in cardiovascular medicine

Avec: Alkmini A Papadopoulou , Regina Fluhrer

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.

The Journal of experimental medicine

Avec: Torben Mentrup , Kosta Theodorou , Florencia Cabrera-Cabrera , Andreas O Helbig , Kathrin Happ , Marion Gijbels , Ann-Christine Gradtke , Björn Rabe , Akio Fukumori , Harald Steiner , Andreas Tholey , Regina Fluhrer , Marjo Donners , Bernd Schröder

Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.

Scientific reports

Avec: Alkmini A Papadopoulou , Walter Stelzer , Mara Silber , Christine Schlosser , Charlotte Spitz , Martina Haug-Kröper , Tobias Straub , Stephan A Müller , Stefan F Lichtenthaler , Claudia Muhle-Goll , Dieter Langosch , Regina Fluhrer

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.

EMBO reports

Avec: Johannes Niemeyer , Torben Mentrup , Ronny Heidasch , Stephan A Müller , Uddipta Biswas , Rieke Meyer , Alkmini A Papadopoulou , Verena Dederer , Martina Haug-Kröper , Vivian Adamski , Renate Lüllmann-Rauch , Martin Bergmann , Artur Mayerhofer , Paul Saftig , Gunther Wennemuth , Rolf Jessberger , Regina Fluhrer , Stefan F Lichtenthaler , Marius K Lemberg , Bernd Schröder

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.

EMBO reports

Avec: Alkmini A Papadopoulou , Stephan A Müller , Torben Mentrup , Merav D Shmueli , Johannes Niemeyer , Martina Haug-Kröper , Julia von Blume , Artur Mayerhofer , Regina Feederle , Bernd Schröder , Stefan F Lichtenthaler , Regina Fluhrer

Physiological functions of SPP/SPPL intramembrane proteases.

Cellular and molecular life sciences : CMLS

Avec: Torben Mentrup , Florencia Cabrera-Cabrera , Regina Fluhrer , Bernd Schröder

Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.

Nature communications

Avec: Torben Mentrup , Anna Yamina Stumpff-Niggemann , Nadja Leinung , Christine Schlosser , Katja Schubert , Rebekka Wehner , Antje Tunger , Valentin Schatz , Patrick Neubert , Ann-Christine Gradtke , Janina Wolf , Stefan Rose-John , Paul Saftig , Alexander Dalpke , Jonathan Jantsch , Marc Schmitz , Regina Fluhrer , Ilse D Jacobsen , Bernd Schröder

The role of SPP/SPPL intramembrane proteases in membrane protein homeostasis.

The FEBS journal

Avec: Torben Mentrup , Nadja Leinung , Mehul Patel , Regina Fluhrer , Bernd Schröder

Signal Peptide Peptidase-Like 2b Modulates the Amyloidogenic Pathway and exhibits an Aβ-dependent expression in Alzheimer's Disease.

Progress in neurobiology

Avec: Riccardo Maccioni , Caterina Travisan , Jack Badman , Stefania Zerial , Annika Wagener , Yuniesky Andrade-Talavera , Federico Picciau , Caterina Grassi , Gefei Chen , Laetitia Lemoine , André Fisahn , Richeng Jiang , Regina Fluhrer , Torben Mentrup , Bernd Schröder , Per Nilsson , Simone Tambaro

In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context.

Chemico-biological interactions

Avec: Kinda Sharrouf , Christine Schlosser , Sandra Mildenberger , Regina Fluhrer , Sabine Hoeppner

Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix.

iScience

Avec: Charlotte Spitz , Christine Schlosser , Nadja Guschtschin-Schmidt , Walter Stelzer , Simon Menig , Alexander Götz , Martina Haug-Kröper , Christina Scharnagl , Dieter Langosch , Claudia Muhle-Goll , Regina Fluhrer

Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Manuel S Brugger , Kathrin Baumgartner , Sophie C F Mauritz , Stefan C Gerlach , Florian Röder , Christine Schlosser , Regina Fluhrer , Achim Wixforth , Christoph Westerhausen

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19.

Nature communications

Avec: Amanda Heard , Jack H Landmann , Ava R Hansen , Alkmini Papadopolou , Yu-Sung Hsu , Mehmet Emrah Selli , John M Warrington , John Lattin , Jufang Chang , Helen Ha , Martina Haug-Kroeper , Balraj Doray , Saar Gill , Marco Ruella , Katharina E Hayer , Matthew D Weitzman , Abby M Green , Regina Fluhrer , Nathan Singh

Structure and function of SPP/SPPL proteases: insights from biochemical evidence and predictive modeling.

The FEBS journal

Avec: Sabine Höppner , Bernd Schröder , Regina Fluhrer

Réseau de co-auteurs

Bernd Schröder 8 collaborations

Torben Mentrup 7 collaborations

Christine Schlosser 5 collaborations

Alkmini A Papadopoulou 4 collaborations

Martina Haug-Kröper 4 collaborations

Stephan A Müller 3 collaborations

Stefan F Lichtenthaler 3 collaborations

Florencia Cabrera-Cabrera 2 collaborations

Ann-Christine Gradtke 2 collaborations

Walter Stelzer 2 collaborations

Charlotte Spitz 2 collaborations

Claudia Muhle-Goll 2 collaborations

Dieter Langosch 2 collaborations

Johannes Niemeyer 2 collaborations

Artur Mayerhofer 2 collaborations

Paul Saftig 2 collaborations

Nadja Leinung 2 collaborations

Kosta Theodorou 1 collaboration

Andreas O Helbig 1 collaboration

Kathrin Happ 1 collaboration

Marion Gijbels 1 collaboration

Björn Rabe 1 collaboration

Akio Fukumori 1 collaboration

Harald Steiner 1 collaboration

Andreas Tholey 1 collaboration

Marjo Donners 1 collaboration

Mara Silber 1 collaboration

Tobias Straub 1 collaboration

Ronny Heidasch 1 collaboration

Uddipta Biswas 1 collaboration

Rieke Meyer 1 collaboration

Verena Dederer 1 collaboration

Vivian Adamski 1 collaboration

Renate Lüllmann-Rauch 1 collaboration

Martin Bergmann 1 collaboration

Gunther Wennemuth 1 collaboration

Rolf Jessberger 1 collaboration

Marius K Lemberg 1 collaboration

Merav D Shmueli 1 collaboration

Julia von Blume 1 collaboration

Regina Feederle 1 collaboration

Anna Yamina Stumpff-Niggemann 1 collaboration

Katja Schubert 1 collaboration

Rebekka Wehner 1 collaboration

Antje Tunger 1 collaboration

Valentin Schatz 1 collaboration

Patrick Neubert 1 collaboration

Janina Wolf 1 collaboration

Stefan Rose-John 1 collaboration

Alexander Dalpke 1 collaboration

Jonathan Jantsch 1 collaboration

Marc Schmitz 1 collaboration

Ilse D Jacobsen 1 collaboration

Mehul Patel 1 collaboration

Riccardo Maccioni 1 collaboration

Caterina Travisan 1 collaboration

Jack Badman 1 collaboration

Stefania Zerial 1 collaboration

Annika Wagener 1 collaboration

Yuniesky Andrade-Talavera 1 collaboration

Federico Picciau 1 collaboration

Caterina Grassi 1 collaboration

Gefei Chen 1 collaboration

Laetitia Lemoine 1 collaboration

André Fisahn 1 collaboration

Richeng Jiang 1 collaboration

Per Nilsson 1 collaboration

Simone Tambaro 1 collaboration

Kinda Sharrouf 1 collaboration

Sandra Mildenberger 1 collaboration

Sabine Hoeppner 1 collaboration

Nadja Guschtschin-Schmidt 1 collaboration

Simon Menig 1 collaboration

Alexander Götz 1 collaboration

Christina Scharnagl 1 collaboration

Manuel S Brugger 1 collaboration

Kathrin Baumgartner 1 collaboration

Sophie C F Mauritz 1 collaboration

Stefan C Gerlach 1 collaboration

Florian Röder 1 collaboration

Achim Wixforth 1 collaboration

Christoph Westerhausen 1 collaboration

Amanda Heard 1 collaboration

Jack H Landmann 1 collaboration

Ava R Hansen 1 collaboration

Alkmini Papadopolou 1 collaboration

Yu-Sung Hsu 1 collaboration

Mehmet Emrah Selli 1 collaboration

John M Warrington 1 collaboration

John Lattin 1 collaboration

Jufang Chang 1 collaboration

Helen Ha 1 collaboration

Martina Haug-Kroeper 1 collaboration

Balraj Doray 1 collaboration

Saar Gill 1 collaboration

Marco Ruella 1 collaboration

Katharina E Hayer 1 collaboration

Matthew D Weitzman 1 collaboration

Abby M Green 1 collaboration

Nathan Singh 1 collaboration

Sabine Höppner 1 collaboration