Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
21 Feb 2024
Historique:
medline: 21 2 2024
pubmed: 21 2 2024
entrez: 21 2 2024
Statut: aheadofprint

Résumé

GPR84 is a putative medium-chain fatty acid receptor that is implicated in regulation of inflammation and fibrogenesis. Studies have indicated that GPR84 agonists may have therapeutic potential in diseases such as Alzheimer's disease, atherosclerosis, and cancer, but there is a lack of quality tool compounds to explore this potential. The fatty acid analogue LY237 (

Identifiants

DOI: 10.1021/acs.jmedchem.3c01923 PMID: 38381650
pubmed: 38381650
doi: 10.1021/acs.jmedchem.3c01923
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Loukas Ieremias (L)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Mads H Kaspersen (MH)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.
Department of Physics, Chemistry and Pharmacy, Faculty of Science, University of Southern Denmark, Campusvej 55, 5230 Odense M, Odense, Denmark.

Asmita Manandhar (A)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Katrine Schultz-Knudsen (K)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Christina Ioanna Vrettou (CI)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Rina Pokhrel (R)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Christoffer V Heidtmann (CV)

Department of Physics, Chemistry and Pharmacy, Faculty of Science, University of Southern Denmark, Campusvej 55, 5230 Odense M, Odense, Denmark.
ORCID: 0000-0002-2579-3938

Laura Jenkins (L)

School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

Christina Kanellou (C)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Sara Marsango (S)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Yueming Li (Y)

School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

Hans Bräuner-Osborne (H)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.

Elisabeth Rexen Ulven (E)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.
ORCID: 0000-0003-1243-7587

Graeme Milligan (G)

School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.
ORCID: 0000-0002-6946-3519

Trond Ulven (T)

Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Copenhagen, Denmark.
Department of Physics, Chemistry and Pharmacy, Faculty of Science, University of Southern Denmark, Campusvej 55, 5230 Odense M, Odense, Denmark.
ORCID: 0000-0002-8135-1755

Classifications MeSH