Bibenzyl and naphthalene derivatives from Dendrobium chrysanthum and their anti-hepatic-steatosis activities.

Bibenzyls / pharmacology Dendrobium / chemistry Fatty Liver PPAR alpha RNA, Messenger Sterol Regulatory Element Binding Protein 1 / genetics Naphthalenes / chemistry
Anti-hepatic-steatosis Dendrobium chrysanthum Dimeric bibenzyls Naphthalene derivatives

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
Apr 2024
Historique:
received: 05 11 2023
revised: 11 02 2024
accepted: 19 02 2024
medline: 15 3 2024
pubmed: 26 2 2024
entrez: 25 2 2024
Statut: ppublish

Résumé

In this study, 16 new compounds, six bibenzyls (1-6) and 10 naphthalenes (7-13), including three pairs of naphthalene enantiomers and three known compounds (14-16), were isolated from Dendrobium chrysanthum. Structurally, compounds 1-5 are previously undescribed dimeric bibenzyls, uniquely linked by unusual carbon bonds. The structures of the compounds were determined using spectroscopy and X-ray crystallography. The screening results indicated that 1, 2, and 5 showed remarkable lipid-lowering activities in FFA-induced HepG2 cells, with EC

Identifiants

DOI: 10.1016/j.bioorg.2024.107236 PMID: 38402796
pubmed: 38402796
pii: S0045-2068(24)00141-X
doi: 10.1016/j.bioorg.2024.107236
pii:
doi:

Substances chimiques

Bibenzyls 0
PPAR alpha 0
RNA, Messenger 0
Sterol Regulatory Element Binding Protein 1 0
Naphthalenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

107236

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Zi-Mo Zhang (ZM)

School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei Province 063210, People's Republic of China.

Jin-Ming Chen (JM)

School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei Province 063210, People's Republic of China.

Xiao-Xia Wang (XX)

School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei Province 063210, People's Republic of China.

Ling-Yun Wang (LY)

Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province 210008, People's Republic of China.

Shuai Liu (S)

School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei Province 063210, People's Republic of China.

Jing Wang (J)

Department of Pharmacy, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province 210022, People's Republic of China.

Ya-Nan Wang (YN)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

Peng-Yu Zhuang (PY)

School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei Province 063210, People's Republic of China. Electronic address: zhuangpengyu@ncst.edu.cn.

Lu-Lu Wang (LL)

Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province 210008, People's Republic of China. Electronic address: wanglulu2018@njglyy.com.

Hang Liu (H)

Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province 210008, People's Republic of China. Electronic address: liuhang831123@163.com.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Bibenzyles › Bibenzyl and naphthalene derivatives from...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Orchidaceae › Dendrobium › Bibenzyl and naphthalene derivatives from...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Bibenzyl and naphthalene derivatives from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › Bibenzyl and naphthalene derivatives from...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Bibenzyl and naphthalene derivatives from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Protéine-1 de liaison à l'élément de régulation des stérols › Bibenzyl and naphthalene derivatives from...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Bibenzyl and naphthalene derivatives from...