Exploring transgenerational inheritance in epigenotypes of DAT heterozygous rats: Circadian anomalies and attentional vulnerability.
ADHD
Circadian cycle
Dopamine
Epigenotype
Risk assessment
Transgenerational inheritance
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
27 Apr 2024
27 Apr 2024
Historique:
received:
13
11
2023
revised:
21
02
2024
accepted:
22
02
2024
medline:
18
3
2024
pubmed:
27
2
2024
entrez:
26
2
2024
Statut:
ppublish
Résumé
Dopamine (DA) is mainly involved in locomotor activity, reward processes and maternal behaviors. Rats with KO gene for dopamine transporter (DAT), coding for a truncated DAT protein, are in hyperdopaminergic conditions and thus develop stereotyped behaviors and hyperactivity. Our aim was to test the prior transgenerational modulation of wild and truncated alleles as expressed in heterozygous DAT rats: specifically, we addressed the possible sequelae due to genotype and gender of the ancestors, with regard to behavioral differences in F
Identifiants
pubmed: 38408522
pii: S0166-4328(24)00077-9
doi: 10.1016/j.bbr.2024.114921
pii:
doi:
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114921Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflicts of interest to declare.