Encoding of Visual Objects in the Human Medial Temporal Lobe.
amygdala
entorhinal cortex
hippocampus
medial temporal lobe
neural object coding
parahippocampal cortex
perirhinal cortex
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
17 Apr 2024
17 Apr 2024
Historique:
received:
14
11
2023
revised:
10
02
2024
accepted:
25
02
2024
medline:
19
4
2024
pubmed:
2
3
2024
entrez:
1
3
2024
Statut:
epublish
Résumé
The human medial temporal lobe (MTL) plays a crucial role in recognizing visual objects, a key cognitive function that relies on the formation of semantic representations. Nonetheless, it remains unknown how visual information of general objects is translated into semantic representations in the MTL. Furthermore, the debate about whether the human MTL is involved in perception has endured for a long time. To address these questions, we investigated three distinct models of neural object coding-semantic coding, axis-based feature coding, and region-based feature coding-in each subregion of the human MTL, using high-resolution fMRI in two male and six female participants. Our findings revealed the presence of semantic coding throughout the MTL, with a higher prevalence observed in the parahippocampal cortex (PHC) and perirhinal cortex (PRC), while axis coding and region coding were primarily observed in the earlier regions of the MTL. Moreover, we demonstrated that voxels exhibiting axis coding supported the transition to region coding and contained information relevant to semantic coding. Together, by providing a detailed characterization of neural object coding schemes and offering a comprehensive summary of visual coding information for each MTL subregion, our results not only emphasize a clear role of the MTL in perceptual processing but also shed light on the translation of perception-driven representations of visual features into memory-driven representations of semantics along the MTL processing pathway.
Identifiants
pubmed: 38429107
pii: JNEUROSCI.2135-23.2024
doi: 10.1523/JNEUROSCI.2135-23.2024
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 the authors.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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