Discovering and exploring the hidden diversity of human gut viruses using highly enriched virome samples.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
19 Feb 2024
Historique:
pubmed: 11 3 2024
medline: 11 3 2024
entrez: 11 3 2024
Statut: epublish

Résumé

Viruses are an abundant and crucial component of the human microbiome, but accurately discovering them via metagenomics is still challenging. Currently, the available viral reference genomes poorly represent the diversity in microbiome samples, and expanding such a set of viral references is difficult. As a result, many viruses are still undetectable through metagenomics even when considering the power of

Identifiants

pubmed: 38464031
doi: 10.1101/2024.02.19.580813
pmc: PMC10925137
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : U01 CA230551
Pays : United States

Déclaration de conflit d'intérêts

COI Statement Takuji Yamada (T.Y.) is a founder of Metagen Inc., Metagen Therapeutics Inc., and digzyme Inc. Metagen Inc. focuses on the design and control of the gut environment for human health. Metagen Therapeutics Inc. focuses on drug discovery and development which utilizes microbiome science. Digizyme Inc. focuses on the development of novel enzymes. Hiroaki Kitano (H.K.) is a founder of IOM Bioworks Pvt Ltd., that focuses on health advisory based in gut-microbiome. None of the companies had control over the interpretation, writing, or publication of this work.

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Auteurs

Moreno Zolfo (M)

Department CIBIO, University of Trento, Italy.
Integrated Open Systems Unit, Okinawa Institute of Science and Technology (OIST), Okinawa, Japan.

Andrea Silverj (A)

Department CIBIO, University of Trento, Italy.
Center Agriculture Food Environment (C3A), University of Trento, Italy.
Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.

Aitor Blanco-Míguez (A)

Department CIBIO, University of Trento, Italy.

Paolo Manghi (P)

Department CIBIO, University of Trento, Italy.

Omar Rota-Stabelli (O)

Department CIBIO, University of Trento, Italy.
Center Agriculture Food Environment (C3A), University of Trento, Italy.
Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.

Vitor Heidrich (V)

Department CIBIO, University of Trento, Italy.

Jordan Jensen (J)

Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Sagun Maharjan (S)

Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Eric Franzosa (E)

Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Cristina Menni (C)

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.

Alessia Visconti (A)

Center for Biostatistics, Epidemiology and Public Health, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

Federica Pinto (F)

Department CIBIO, University of Trento, Italy.

Matteo Ciciani (M)

Department CIBIO, University of Trento, Italy.

Curtis Huttenhower (C)

Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Anna Cereseto (A)

Department CIBIO, University of Trento, Italy.

Francesco Asnicar (F)

Department CIBIO, University of Trento, Italy.

Hiroaki Kitano (H)

Integrated Open Systems Unit, Okinawa Institute of Science and Technology (OIST), Okinawa, Japan.
The Systems Biology Institute (SBI), Tokyo, Japan.
IOM Bioworks Pvt. Ltd., Centre for Cellular and Molecular Platforms (C-CAMP), GKVK Post, Bellary Rd, Bengaluru, Karnataka-560065, India.

Takuji Yamada (T)

Integrated Open Systems Unit, Okinawa Institute of Science and Technology (OIST), Okinawa, Japan.
School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.
Metagen, Inc., Yamagata, Japan.
Metagen Therapeutics, Inc., Yamagata, Japan.
digzyme, Inc., Tokyo, Japan.

Nicola Segata (N)

Department CIBIO, University of Trento, Italy.
Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.

Classifications MeSH