The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas.
Journal
Cancer metastasis reviews
ISSN: 1573-7233
Titre abrégé: Cancer Metastasis Rev
Pays: Netherlands
ID NLM: 8605731
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
received:
15
01
2024
accepted:
02
03
2024
medline:
11
3
2024
pubmed:
11
3
2024
entrez:
11
3
2024
Statut:
aheadofprint
Résumé
We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, characterized by a well-defined multigene signature including APOD, DCN, and LUM. This cell population has previously been labeled as consisting of inflammatory cancer-associated fibroblasts (iCAFs). The same signature characterizes naturally occurring fibro-adipogenic progenitors (FAPs) as well as stromal cells abundant in normal adipose tissue. Our analysis of human gene expression databases provides evidence that adipose stromal cells (ASCs) are recruited by tumors and undergo differentiation into CAFs during cancer progression to invasive and chemotherapy-resistant stages.
Identifiants
pubmed: 38466528
doi: 10.1007/s10555-024-10181-y
pii: 10.1007/s10555-024-10181-y
doi:
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Caligiuri, G., & Tuveson, D. A. (2023). Activated fibroblasts in cancer: Perspectives and challenges. Cancer Cell, 41, 434–449.
doi: 10.1016/j.ccell.2023.02.015
pubmed: 36917949
Vijay, J., et al. (2020). Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types. Nature Metabolism, 2, 97–109.
doi: 10.1038/s42255-019-0152-6
pubmed: 32066997
Rubenstein, A. B., et al. (2020). Single-cell transcriptional profiles in human skeletal muscle. Scientfic Reports, 10, 229.
doi: 10.1038/s41598-019-57110-6
Sastourné-Arrey, Q., et al. (2023). Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury. Nature Communications, 14, 80.
doi: 10.1038/s41467-022-35524-7
pubmed: 36604419
pmcid: 9816314
Cheng, W.-Y., Yang, O., & T.-H. & Anastassiou, D. (2013). Biomolecular events in cancer revealed by attractor metagenes. PLOS Computational Biology, 9, e1002920.
doi: 10.1371/journal.pcbi.1002920
pubmed: 23468608
pmcid: 3581797
Chen, Z., et al. (2020). Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma. Nature Communications, 11, 5077.
doi: 10.1038/s41467-020-18916-5
pubmed: 33033240
pmcid: 7545162
Hornburg, M., et al. (2021). Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer. Cancer Cell, 39, 928–944.e6.
doi: 10.1016/j.ccell.2021.04.004
pubmed: 33961783
Wu, S. Z., et al. (2021). A single-cell and spatially resolved atlas of human breast cancers. Nature Genetics, 53, 1334–1347.
doi: 10.1038/s41588-021-00911-1
pubmed: 34493872
pmcid: 9044823
Cui Zhou, D., et al. (2022). Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nature Genetics, 54, 1390–1405.
doi: 10.1038/s41588-022-01157-1
pubmed: 35995947
pmcid: 9470535
Zhang, Y., et al. (2012). Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Research, 72, 5198–5208.
doi: 10.1158/0008-5472.CAN-12-0294
pubmed: 23071132
Zhang, T., et al. (2016). CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment. Nature Communications, 7, 11674.
doi: 10.1038/ncomms11674
pubmed: 27241286
pmcid: 4895055
Öhlund, D., et al. (2017). Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. Journal of Experimental Medicine, 214, 579–596.
doi: 10.1084/jem.20162024
pubmed: 28232471
pmcid: 5339682
Sahai, E., et al. (2020). A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews Cancer, 20, 174–186.
doi: 10.1038/s41568-019-0238-1
pubmed: 31980749
pmcid: 7046529
Dominguez, C. X., et al. (2020). Single-cell rna sequencing reveals stromal evolution into lrrc15+ myofibroblasts as a determinant of patient response to cancer immunotherapy. Cancer Discovery, 10, 232–253.
doi: 10.1158/2159-8290.CD-19-0644
pubmed: 31699795
Elyada, E., et al. (2019). Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discovery, 9, 1102–1123.
doi: 10.1158/2159-8290.CD-19-0094
pubmed: 31197017
pmcid: 6727976
Thorlacius-Ussing, J., et al. (2023). The collagen landscape in cancer: profiling collagens in tumors and in circulation reveals novel markers of cancer-associated fibroblast subtypes. The Journal of Pathology, 262(1), 22–36.
doi: 10.1002/path.6207
pubmed: 37728068
Zhu, K., Cai, L., Cui, C., de Los Toyos, J. R., & Anastassiou, D. (2021). Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts. PLOS Computational Biology, 17, e1009228.
doi: 10.1371/journal.pcbi.1009228
pubmed: 34283835
pmcid: 8323949
Kim, H., Watkinson, J., Varadan, V., & Anastassiou, D. (2010). Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1. BMC Medical Genomics, 3, 51.
doi: 10.1186/1755-8794-3-51
pubmed: 21047417
pmcid: 2988703
Wang, Y., et al. (2021). Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response. Cell Discovery, 7, 1–17.
doi: 10.1038/s41421-021-00271-4
pubmed: 33390590
pmcid: 7779601
Zhao, Z., et al. (2023). Integrative analysis of cancer-associated fibroblast signature in gastric cancer. Heliyon, 9, e19217.
doi: 10.1016/j.heliyon.2023.e19217
pubmed: 37809716
pmcid: 10558323
Lengyel, E., Makowski, L., DiGiovanni, J., & Kolonin, M. G. (2018). Cancer as a matter of fat: the crosstalk between adipose tissue and tumors. Trends Cancer, 4, 374–384.
doi: 10.1016/j.trecan.2018.03.004
pubmed: 29709261
pmcid: 5932630