The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
11 Mar 2024
Historique:
medline: 12 3 2024
pubmed: 12 3 2024
entrez: 12 3 2024
Statut: aheadofprint

Résumé

Interleukin receptor-associated kinase 4 (IRAK4) is a key node of signaling within the innate immune system that regulates the production of inflammatory cytokines and chemokines. The presence of

Identifiants

DOI: 10.1021/acs.jmedchem.3c02226 PMID: 38467640
pubmed: 38467640
doi: 10.1021/acs.jmedchem.3c02226
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Ryan Evans (R)

Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Philippe N Bolduc (PN)

Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
ORCID: 0000-0001-8726-4364

Magnus Pfaffenbach (M)

Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
ORCID: 0000-0002-0068-6829

Fang Gao (F)

Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Tricia May-Dracka (T)

Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Terry Fang (T)

Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Brian T Hopkins (BT)

Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
ORCID: 0000-0002-2912-9954

Jayanth V Chodaparambil (JV)

Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Kate L Henry (KL)

Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Pei Li (P)

Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
ORCID: 0000-0003-0634-5213

Claire Metrick (C)

Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Ashley Nelson (A)

Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Patrick Trapa (P)

Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Ankur Thomas (A)

Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Linda Burkly (L)

Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Emily A Peterson (EA)

Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
ORCID: 0000-0001-5854-2505

Classifications MeSH