Patrick Trapa

Affiliations

Biotherapeutics and Medicinal Sciences Biogen Cambridge MA USA.

Publications (10)

Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.

Clinical & translational immunology

Avec: Eris Bame , Hao Tang , Jeremy C Burns , Million Arefayene , Klaus Michelsen , Bin Ma , Isaac Marx , Robin Prince , Allie M Roach , Urjana Poreci , Douglas Donaldson , Patrick Cullen , Fergal Casey , Jing Zhu , Thomas M Carlile , Dipen Sangurdekar , Baohong Zhang , Patrick Trapa , Joseph Santoro , Param Muragan , Alex Pellerin , Stephen Rubino , Davide Gianni , Bekim Bajrami , Xiaomei Peng , Alex Coppell , Katherine Riester , Shibeshih Belachew , Devangi Mehta , Mike Palte , Brian T Hopkins , Matthew Scaramozza , Nathalie Franchimont , Michael Mingueneau

Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit.

Toxicologic pathology

Avec: Eric Tien , Branka Grubor , Melissa Kirkland , Su Jing Chan , Nick van der Munnik , Wenlong Xu , Kate Henry , Stefan Hamann , Cong Wei , Wan-Hung Lee , Davide Gianni , Ashton Brennecke , Kalyani Nambiar , Jeron Chen , Bin Liu , Shen Shen , Claudine Tremblay , Edward D Plowey , Patrick Trapa , James Fikes , Junghae Suh , Dale Morris

Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.

Journal of medicinal chemistry

Avec: Martin Pettersson , Douglas S Johnson , John M Humphrey , Christopher W Am Ende , Todd W Butler , Peter H Dorff , Ivan V Efremov , Edelweiss Evrard , Michael E Green , Christopher J Helal , Gregory W Kauffman , Patrick B Mullins , Thayalan Navaratnam , Christopher J O'Donnell , Theresa J O'Sullivan , Nandini C Patel , Antonia F Stepan , Cory M Stiff , Chakrapani Subramanyam , Patrick Trapa , Tuan P Tran , Beth Cooper Vetelino , Eddie Yang , Longfei Xie , Leslie R Pustilnik , Stefanus J Steyn , Kathleen M Wood , Kelly R Bales , Eva Hajos-Korcsok , Patrick R Verhoest

D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects.

ACS chemical neuroscience

Avec: Damon Young , Michael Popiolek , Patrick Trapa , Kari R Fonseca , Julie Brevard , David L Gray , Rouba Kozak

Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity.

Journal of medicinal chemistry

Avec: Lei Zhang , Christopher R Butler , Kevin P Maresca , Akihiro Takano , Sangram Nag , Zhisheng Jia , Ryosuke Arakawa , Justin R Piro , Tarek Samad , Deborah L Smith , Deane M Nason , Steven O'Neil , Laura McAllister , Klaas Schildknegt , Patrick Trapa , Timothy J McCarthy , Anabella Villalobos , Christer Halldin

Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors.

Molecular therapy. Methods & clinical development

Avec: Pete Clarner , Shukkwan K Lau , Twinkle Chowdhury , Edward Guilmette , Patrick Trapa , Shih-Ching Lo , Shen Shen

Target occupancy study and whole-body dosimetry with a MAGL PET ligand [

EJNMMI research

Avec: Ryosuke Arakawa , Akihiro Takano , Sangram Nag , Zhisheng Jia , Nahid Amini , Kevin P Maresca , Lei Zhang , Edmund J Keliher , Christopher R Butler , Justin R Piro , Tarek A Samad , Deborah Smith , Deane Nason , Steve O'Neil , Patrick Trapa , Kari R Fonseca , John Litchfield , Timothy McCarthy , Richard E Carson , Christer Halldin

Optimization of dose and route of administration of the P-glycoprotein inhibitor, valspodar (PSC-833) and the P-glycoprotein and breast cancer resistance protein dual-inhibitor, elacridar (GF120918) as dual infusion in rats.

Pharmacology research & perspectives

Avec: Christopher Rowbottom , Alicia Pietrasiewicz , Taras Tuczewycz , Richard Grater , Daniel Qiu , Sudarshan Kapadnis , Patrick Trapa

Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective.

Journal of chemical information and modeling

Avec: Cheng Fang , Ye Wang , Richard Grater , Sudarshan Kapadnis , Cheryl Black , Patrick Trapa , Simone Sciabola

The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-

Journal of medicinal chemistry

Avec: Ryan Evans , Philippe N Bolduc , Magnus Pfaffenbach , Fang Gao , Tricia May-Dracka , Terry Fang , Brian T Hopkins , Jayanth V Chodaparambil , Kate L Henry , Pei Li , Claire Metrick , Ashley Nelson , Patrick Trapa , Ankur Thomas , Linda Burkly , Emily A Peterson

Réseau de co-auteurs

Davide Gianni 2 collaborations

Brian T Hopkins 2 collaborations

Shen Shen 2 collaborations

Kari R Fonseca 2 collaborations

Lei Zhang 2 collaborations

Christopher R Butler 2 collaborations

Kevin P Maresca 2 collaborations

Akihiro Takano 2 collaborations

Sangram Nag 2 collaborations

Zhisheng Jia 2 collaborations

Ryosuke Arakawa 2 collaborations

Justin R Piro 2 collaborations

Christer Halldin 2 collaborations

Richard Grater 2 collaborations

Sudarshan Kapadnis 2 collaborations

Eris Bame 1 collaboration

Hao Tang 1 collaboration

Jeremy C Burns 1 collaboration

Million Arefayene 1 collaboration

Klaus Michelsen 1 collaboration

Bin Ma 1 collaboration

Isaac Marx 1 collaboration

Robin Prince 1 collaboration

Allie M Roach 1 collaboration

Urjana Poreci 1 collaboration

Douglas Donaldson 1 collaboration

Patrick Cullen 1 collaboration

Fergal Casey 1 collaboration

Jing Zhu 1 collaboration

Thomas M Carlile 1 collaboration

Dipen Sangurdekar 1 collaboration

Baohong Zhang 1 collaboration

Joseph Santoro 1 collaboration

Param Muragan 1 collaboration

Alex Pellerin 1 collaboration

Stephen Rubino 1 collaboration

Bekim Bajrami 1 collaboration

Xiaomei Peng 1 collaboration

Alex Coppell 1 collaboration

Katherine Riester 1 collaboration

Shibeshih Belachew 1 collaboration

Devangi Mehta 1 collaboration

Mike Palte 1 collaboration

Matthew Scaramozza 1 collaboration

Nathalie Franchimont 1 collaboration

Michael Mingueneau 1 collaboration

Eric Tien 1 collaboration

Branka Grubor 1 collaboration

Melissa Kirkland 1 collaboration

Su Jing Chan 1 collaboration

Nick van der Munnik 1 collaboration

Wenlong Xu 1 collaboration

Kate Henry 1 collaboration

Stefan Hamann 1 collaboration

Cong Wei 1 collaboration

Wan-Hung Lee 1 collaboration

Ashton Brennecke 1 collaboration

Kalyani Nambiar 1 collaboration

Jeron Chen 1 collaboration

Bin Liu 1 collaboration

Claudine Tremblay 1 collaboration

Edward D Plowey 1 collaboration

James Fikes 1 collaboration

Junghae Suh 1 collaboration

Dale Morris 1 collaboration

Martin Pettersson 1 collaboration

Douglas S Johnson 1 collaboration

John M Humphrey 1 collaboration

Christopher W Am Ende 1 collaboration

Todd W Butler 1 collaboration

Peter H Dorff 1 collaboration

Ivan V Efremov 1 collaboration

Edelweiss Evrard 1 collaboration

Michael E Green 1 collaboration

Christopher J Helal 1 collaboration

Gregory W Kauffman 1 collaboration

Patrick B Mullins 1 collaboration

Thayalan Navaratnam 1 collaboration

Christopher J O'Donnell 1 collaboration

Theresa J O'Sullivan 1 collaboration

Nandini C Patel 1 collaboration

Antonia F Stepan 1 collaboration

Cory M Stiff 1 collaboration

Chakrapani Subramanyam 1 collaboration

Tuan P Tran 1 collaboration

Beth Cooper Vetelino 1 collaboration

Eddie Yang 1 collaboration

Longfei Xie 1 collaboration

Leslie R Pustilnik 1 collaboration

Stefanus J Steyn 1 collaboration

Kathleen M Wood 1 collaboration

Kelly R Bales 1 collaboration

Eva Hajos-Korcsok 1 collaboration

Patrick R Verhoest 1 collaboration

Damon Young 1 collaboration

Michael Popiolek 1 collaboration

Julie Brevard 1 collaboration

David L Gray 1 collaboration

Rouba Kozak 1 collaboration

Tarek Samad 1 collaboration

Deborah L Smith 1 collaboration

Deane M Nason 1 collaboration

Steven O'Neil 1 collaboration

Laura McAllister 1 collaboration

Klaas Schildknegt 1 collaboration

Timothy J McCarthy 1 collaboration

Anabella Villalobos 1 collaboration

Pete Clarner 1 collaboration

Shukkwan K Lau 1 collaboration

Twinkle Chowdhury 1 collaboration

Edward Guilmette 1 collaboration

Shih-Ching Lo 1 collaboration

Nahid Amini 1 collaboration

Edmund J Keliher 1 collaboration

Tarek A Samad 1 collaboration

Deborah Smith 1 collaboration

Deane Nason 1 collaboration

Steve O'Neil 1 collaboration

John Litchfield 1 collaboration

Timothy McCarthy 1 collaboration

Richard E Carson 1 collaboration

Christopher Rowbottom 1 collaboration

Alicia Pietrasiewicz 1 collaboration

Taras Tuczewycz 1 collaboration

Daniel Qiu 1 collaboration

Cheng Fang 1 collaboration

Ye Wang 1 collaboration

Cheryl Black 1 collaboration

Simone Sciabola 1 collaboration

Ryan Evans 1 collaboration

Philippe N Bolduc 1 collaboration

Magnus Pfaffenbach 1 collaboration

Fang Gao 1 collaboration

Tricia May-Dracka 1 collaboration

Terry Fang 1 collaboration

Jayanth V Chodaparambil 1 collaboration

Kate L Henry 1 collaboration

Pei Li 1 collaboration

Claire Metrick 1 collaboration

Ashley Nelson 1 collaboration

Ankur Thomas 1 collaboration

Linda Burkly 1 collaboration

Emily A Peterson 1 collaboration