Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
07 Jun 2024
Historique:
medline: 8 6 2024
pubmed: 8 6 2024
entrez: 7 6 2024
Statut: aheadofprint

Résumé

Herein, we describe the design and synthesis of γ-secretase modulator (GSM) clinical candidate PF-06648671 (

Identifiants

DOI: 10.1021/acs.jmedchem.4c00580 PMID: 38848667
pubmed: 38848667
doi: 10.1021/acs.jmedchem.4c00580
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Martin Pettersson (M)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.
ORCID: 0000-0001-8748-9539

Douglas S Johnson (DS)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.
ORCID: 0000-0003-2703-6495

John M Humphrey (JM)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Christopher W Am Ende (CW)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
ORCID: 0000-0001-8832-9641

Todd W Butler (TW)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Peter H Dorff (PH)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Ivan V Efremov (IV)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Edelweiss Evrard (E)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Michael E Green (ME)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Christopher J Helal (CJ)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
ORCID: 0000-0002-9091-2091

Gregory W Kauffman (GW)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Patrick B Mullins (PB)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Thayalan Navaratnam (T)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Christopher J O'Donnell (CJ)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
ORCID: 0000-0003-1004-7139

Theresa J O'Sullivan (TJ)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Nandini C Patel (NC)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.
ORCID: 0000-0002-2735-7662

Antonia F Stepan (AF)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Cory M Stiff (CM)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Chakrapani Subramanyam (C)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Patrick Trapa (P)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Tuan P Tran (TP)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
ORCID: 0000-0001-9578-639X

Beth Cooper Vetelino (BC)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Eddie Yang (E)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Longfei Xie (L)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Leslie R Pustilnik (LR)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Stefanus J Steyn (SJ)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Kathleen M Wood (KM)

Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Kelly R Bales (KR)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Eva Hajos-Korcsok (E)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Patrick R Verhoest (PR)

Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Classifications MeSH