Peeling the onion: additional layers of regulation in the acid stress response.
CsrA
Salmonella pathogenicity island 2
SsrB
acid stress response
amino acid decarboxylation
carbon storage regulation
two-component regulatory systems
Journal
Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R
Informations de publication
Date de publication:
18 Apr 2024
18 Apr 2024
Historique:
medline:
19
4
2024
pubmed:
15
3
2024
entrez:
15
3
2024
Statut:
ppublish
Résumé
Bacteria are capable of withstanding large changes in osmolality and cytoplasmic pH, unlike eukaryotes that tightly regulate their pH and cellular composition. Previous studies on the bacterial acid stress response described a rapid, brief acidification, followed by immediate recovery. More recent experiments with better pH probes have imaged single living cells, and we now appreciate that following acid stress, bacteria maintain an acidic cytoplasm for as long as the stress remains. This acidification enables pathogens to sense a host environment and turn on their virulence programs, for example, enabling survival and replication within acidic vacuoles. Single-cell analysis identified an intracellular pH threshold of ~6.5. Acid stress reduces the internal pH below this threshold, triggering the assembly of a type III secretion system in
Identifiants
pubmed: 38488356
doi: 10.1128/jb.00069-24
pmc: PMC11025319
doi:
Substances chimiques
Bacterial Proteins
0
Acids
0
CsrA protein, E coli
0
Repressor Proteins
0
RNA-Binding Proteins
0
Escherichia coli Proteins
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0006924Subventions
Organisme : BLRD VA
ID : I01 BX000372
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM058746
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI123640
Pays : United States
Commentaires et corrections
Type : CommentOn
Déclaration de conflit d'intérêts
The author declares no conflict of interest.
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