CRL4


Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
Jun 2024
Historique:
received: 21 02 2024
revised: 07 03 2024
accepted: 07 03 2024
medline: 18 3 2024
pubmed: 16 3 2024
entrez: 15 3 2024
Statut: epublish

Résumé

Centrioles play important roles in the assembly of centrosomes and cilia. Centriole duplication occurs once per cell cycle and is dependent on polo-like kinase 4 (PLK4). To prevent centriole amplification, which is a hallmark of cancer, PLK4 protein levels need to be tightly regulated. Here, we show that the Cullin4A/B-DDB1-DCAF1, CRL4

Identifiants

pubmed: 38490717
pii: 7/6/e202402668
doi: 10.26508/lsa.202402668
pmc: PMC10942865
pii:
doi:

Substances chimiques

Ubiquitin 0
beta-Transducin Repeat-Containing Proteins 0
Ubiquitin-Protein Ligases EC 2.3.2.27
PLK4 protein, human EC 2.7.1.-
Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Grossmann et al.

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Auteurs

Josina Grossmann (J)

Cell Cycle Control and Carcinogenesis, German Cancer Research Center, DKFZ, Heidelberg, Germany.
Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.

Anne-Sophie Kratz (AS)

Cell Cycle Control and Carcinogenesis, German Cancer Research Center, DKFZ, Heidelberg, Germany.
Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.

Alina Kordonsky (A)

School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Gali Prag (G)

School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

Ingrid Hoffmann (I)

Cell Cycle Control and Carcinogenesis, German Cancer Research Center, DKFZ, Heidelberg, Germany ingrid.hoffmann@dkfz.de.

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Classifications MeSH