Cyclic Ion Mobility for Hydrogen/Deuterium Exchange-Mass Spectrometry Applications.
Journal
Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536
Informations de publication
Date de publication:
16 Apr 2024
16 Apr 2024
Historique:
medline:
17
4
2024
pubmed:
2
4
2024
entrez:
1
4
2024
Statut:
ppublish
Résumé
Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful tool to probe protein dynamics. As a bottom-up technique, HDX-MS provides information at peptide-level resolution, allowing structural localization of dynamic changes. Consequently, the HDX-MS data quality is largely determined by the number of peptides that are identified and monitored after deuteration. Integration of ion mobility (IM) into HDX-MS workflows has been shown to increase the data quality by providing an orthogonal mode of peptide ion separation in the gas phase. This is of critical importance for challenging targets such as integral membrane proteins (IMPs), which often suffer from low sequence coverage or redundancy in HDX-MS analyses. The increasing complexity of samples being investigated by HDX-MS, such as membrane mimetic reconstituted and
Identifiants
pubmed: 38561318
doi: 10.1021/acs.analchem.3c05753
pmc: PMC11024883
doi:
Substances chimiques
Deuterium
AR09D82C7G
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5869-5877Références
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