The Virtual Child.

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
04 Apr 2024
Historique:
medline: 4 4 2024
pubmed: 4 4 2024
entrez: 4 4 2024
Statut: ppublish

Résumé

We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.

Identifiants

DOI: 10.1158/2159-8290.CD-23-1500 PMID: 38571421
pubmed: 38571421
pii: 741971
doi: 10.1158/2159-8290.CD-23-1500
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

663-668

Informations de copyright

©2024 American Association for Cancer Research.

Auteurs

Richard J Gilbertson (RJ)

CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0001-7539-9472

Sam Behjati (S)

Wellcome Sanger Institute, Hinxton, United Kingdom.
Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0002-6600-7665

Anna-Lisa Böttcher (AL)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
ORCID: 0009-0002-4573-4035

Marianne E Bronner (ME)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.
ORCID: 0000-0003-4274-1862

Matthew Burridge (M)

Amazon Web Services, London, United Kingdom.
ORCID: 0009-0008-1184-0861

Henrick Clausing (H)

SELECT SouthWest, Germany.
ORCID: 0009-0008-0176-7744

Harry Clifford (H)

NVIDIA, Cambridge, United Kingdom.
ORCID: 0009-0003-8374-5912

Tracey Danaher (T)

Children's Cancer Foundation, Australia.
ORCID: 0000-0002-7248-0889

Laura K Donovan (LK)

University College London Great Ormond Street Institute of Child Health, United Kingdom.
ORCID: 0000-0001-5557-5539

Jarno Drost (J)

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Oncode Institute, Utrecht, the Netherlands.
ORCID: 0000-0002-2941-6179

Alexander M M Eggermont (AMM)

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
ORCID: 0000-0002-4278-040X

Chris Emerson (C)

NVIDIA, Cambridge, United Kingdom.
ORCID: 0009-0006-0317-5414

Mona G Flores (MG)

NVIDIA, Santa Clara, California.
ORCID: 0000-0002-7362-3044

Petra Hamerlik (P)

University of Manchester, Manchester, United Kingdom.
ORCID: 0000-0002-5856-0161

Nada Jabado (N)

Department of Paediatrics, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
ORCID: 0000-0003-2485-3692

Andrew Jones (A)

Amazon Web Services, London, United Kingdom.
ORCID: 0009-0003-8767-9289

Henrick Kaessmann (H)

Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.
ORCID: 0000-0001-7563-839X

Claudia L Kleinman (CL)

Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada.
Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-5158-7126

Marcel Kool (M)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
ORCID: 0000-0002-6557-5468

Lena M Kutscher (LM)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-1130-4582

Gavin Lindberg (G)

The EVAN Foundation, Maryland.
ORCID: 0009-0005-7382-9228

Emily Linnane (E)

CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0002-0345-4134

John C Marioni (JC)

CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Wellcome Sanger Institute, Hinxton, United Kingdom.
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.
ORCID: 0000-0001-9092-0852

John M Maris (JM)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
ORCID: 0000-0002-8088-7929

Michelle Monje (M)

Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
ORCID: 0000-0002-3547-237X

Alexandra Macaskill (A)

AstraZeneca, Oncology R&D, Cambridge, United Kingdom.
ORCID: 0009-0004-9121-3497

Steven Niederer (S)

Turing Research and Innovation Cluster in Digital Twins (TRIC: DT), The Alan Turing Institute, London, United Kingdom.
ORCID: 0000-0002-4612-6982

Paul A Northcott (PA)

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee.
ORCID: 0000-0002-1220-5252

Elizabeth Peeters (E)

b.r.a.i.n.child, SickKids Hospital, Toronto, Ontario, Canada.
ORCID: 0009-0004-9675-8496

Willemijn Plieger-van Solkema (W)

Dutch Childhood Cancer Organization (VKKN), the Netherlands.
ORCID: 0000-0003-3911-477X

Liane Preußner (L)

BioNTech SE, Mainz, Germany.
ORCID: 0000-0002-9586-7015

Anne C Rios (AC)

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
ORCID: 0000-0002-9082-8068

Karsten Rippe (K)

German Cancer Research Center (DKFZ) Heidelberg, Division of Chromatin Networks, Heidelberg, Germany.
ORCID: 0000-0001-9951-9395

Peter Sandford (P)

Amazon Web Services, London, United Kingdom.
ORCID: 0009-0007-9892-5712

Nikolaos G Sgourakis (NG)

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Pathology and Lab Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
ORCID: 0000-0003-3655-3902

Adam Shlien (A)

Genetics and Genomics Program, The Hospital for Sick Children, Toronto, Canada.
ORCID: 0000-0002-0368-5370

Pete Smith (P)

Hula Therapeutics, Philadelphia, Pennsylvania.
ORCID: 0009-0008-8733-851X

Karin Straathof (K)

University College London Cancer Institute, London, United Kingdom.
Great Ormond Street Hospital for Children, London, United Kingdom.
ORCID: 0000-0001-9673-8568

Patrick J Sullivan (PJ)

Team Finn Foundation, Vancouver, British Columbia, Canada.
ORCID: 0009-0000-9120-8963

Mario L Suvà (ML)

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Broad Institute of MIT and Harvard, Boston, Massachusetts.
ORCID: 0000-0001-9898-5351

Michael D Taylor (MD)

Texas Children's Cancer Center, Hematology-Oncology Section and Department of Pediatrics - Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, Texas.
ORCID: 0009-0001-7181-1906

Emma Thompson (E)

Brain Tumour Charity, Fleet, United Kingdom.
ORCID: 0009-0001-7168-3465

Roser Vento-Tormo (R)

Wellcome Sanger Institute, Hinxton, United Kingdom.
ORCID: 0000-0002-9870-8474

Brandon J Wainwright (BJ)

The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.
ORCID: 0000-0003-0406-2092

Robert J Wechsler-Reya (RJ)

Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
ORCID: 0000-0002-7463-8352

Frank Westermann (F)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0003-1584-3636

Shannon Winslade (S)

Brain Tumour Charity, Fleet, United Kingdom.
ORCID: 0009-0002-6750-955X

Bissan Al-Lazikani (B)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
ORCID: 0000-0003-3367-2519

Stefan M Pfister (SM)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
ORCID: 0000-0002-5447-5322

Classifications MeSH