The Hallmarks of Precancer.

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
04 Apr 2024
Historique:
medline: 4 4 2024
pubmed: 4 4 2024
entrez: 4 4 2024
Statut: ppublish

Résumé

Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

Identifiants

DOI: 10.1158/2159-8290.CD-23-1550 PMID: 38571435
pubmed: 38571435
pii: 741985
doi: 10.1158/2159-8290.CD-23-1550
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

683-689

Informations de copyright

©2024 American Association for Cancer Research.

Auteurs

Mary M Stangis (MM)

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Gastroenterology Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
ORCID: 0000-0003-4139-0861

Zhengyi Chen (Z)

Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee.
Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.
ORCID: 0000-0003-4774-945X

Jimin Min (J)

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas.
ORCID: 0000-0002-2309-7875

Sarah E Glass (SE)

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
ORCID: 0000-0002-0642-2656

Jordan O Jackson (JO)

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.
Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
ORCID: 0000-0002-1225-912X

Megan D Radyk (MD)

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan.
ORCID: 0000-0002-3660-2906

Xen Ping Hoi (XP)

Department of Urology, Houston Methodist Research Institute, Houston, Texas.
Neal Cancer Center, Houston Methodist Research Institute, Houston, Texas.
ORCID: 0000-0001-7610-7291

W Nathaniel Brennen (WN)

Genitourinary Cancer Disease Division, Department of Oncology, Johns Hopkins Medicine, Baltimore, Maryland.
Department of Pharmacology and Molecular Sciences, Johns Hopkins Medicine, Baltimore, Maryland.
Department of Urology, Johns Hopkins Medicine, Baltimore, Maryland.
ORCID: 0000-0001-9807-7433

Ming Yu (M)

Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington.
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.
ORCID: 0000-0001-8692-6135

Huy Q Dinh (HQ)

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin.
ORCID: 0000-0002-3307-1126

Robert J Coffey (RJ)

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Division of Gastroenterology, Hepatology, & Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
ORCID: 0000-0002-2180-3844

Martha J Shrubsole (MJ)

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
ORCID: 0000-0002-5591-7575

Keith S Chan (KS)

Department of Urology, Houston Methodist Research Institute, Houston, Texas.
Neal Cancer Center, Houston Methodist Research Institute, Houston, Texas.
ORCID: 0000-0003-1670-8508

William M Grady (WM)

Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington.
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.
ORCID: 0000-0002-0129-7809

Srinivasan Yegnasubramanian (S)

Genitourinary Cancer Disease Division, Department of Oncology, Johns Hopkins Medicine, Baltimore, Maryland.
Molecular Radiation Science Division, Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, Maryland.
Kidney-Urologic Pathology Division, Department of Pathology, Johns Hopkins Medicine, Baltimore, Maryland.
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland.
ORCID: 0000-0003-0744-6606

Costas A Lyssiotis (CA)

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan.
Division of Gastroenterology, Internal Medicine, University of Washington, Seattle, Washington.
Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.
ORCID: 0000-0001-9309-6141

Anirban Maitra (A)

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas.
ORCID: 0000-0001-7923-9978

Richard B Halberg (RB)

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Gastroenterology Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
ORCID: 0000-0001-6886-1534

Neelendu Dey (N)

Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington.
ORCID: 0000-0001-8825-5689

Ken S Lau (KS)

Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee.
Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
ORCID: 0000-0001-8438-0319

Classifications MeSH