W Nathaniel Brennen

Affiliations

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University, Baltimore, Maryland.

ORCID: 0000-0001-9807-7433

Publications (28)

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

The Prostate

Avec: Timothy E Krueger , Daniel L J Thorek , Alan K Meeker , John T Isaacs , W Nathaniel Brennen

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry.

Nature communications

Avec: Peng Lu , Karolyn A Oetjen , Diane E Bender , Marianna B Ruzinova , Daniel A C Fisher , Kevin G Shim , Russell K Pachynski , W Nathaniel Brennen , Stephen T Oh , Daniel C Link , Daniel L J Thorek

Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia.

Frontiers in molecular biosciences

Avec: Jesus Pacheco-Torres , Raj Kumar Sharma , Yelena Mironchik , Flonne Wildes , W Nathaniel Brennen , Dmitri Artemov , Balaji Krishnamachary , Zaver M Bhujwalla

Characterization of tumor-associated macrophages in prostate cancer transgenic mouse models.

The Prostate

Avec: Amber E de Groot , Kayla V Myers , Timothy E G Krueger , Ashley L Kiemen , Natalia H Nagy , Alexandria Brame , Vicente E Torres , Zhongyuan Zhang , Levent Trabzonlu , W Nathaniel Brennen , Denis Wirtz , Angelo M De Marzo , Sarah R Amend , Kenneth J Pienta

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Cancer research

Avec: Robert M Hughes , Brian W Simons , Hamda Khan , Rebecca Miller , Valentina Kugler , Samantha Torquato , Debebe Theodros , Michael C Haffner , Tamara Lotan , Jessie Huang , Elai Davicioni , Steven S An , Ryan C Riddle , Daniel L J Thorek , Isla P Garraway , Elana J Fertig , John T Isaacs , W Nathaniel Brennen , Ben H Park , Paula J Hurley

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer.

Asian journal of urology

Avec: Emmanuel S Akinboye , W Nathaniel Brennen , Samuel R Denmeade , John T Isaacs

Microparticle Encapsulation of a Prostate-targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-resistant Prostate Cancer.

Molecular cancer therapeutics

Avec: Oliver C Rogers , Lizamma Antony , Oren Levy , Nitin Joshi , Brian W Simons , Susan L Dalrymple , D Marc Rosen , Andrew Pickering , Haoyue Lan , Heidi Kuang , Sudhir H Ranganath , Lei Zheng , Jeffrey M Karp , S Peter Howard , Samuel R Denmeade , John T Isaacs , W Nathaniel Brennen

Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype.

Neoplasia (New York, N.Y.)

Avec: Amber E de Groot , Kayla V Myers , Timothy E G Krueger , W Nathaniel Brennen , Sarah R Amend , Kenneth J Pienta

Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC.

The Journal of clinical investigation

Avec: Laura A Sena , Rajendra Kumar , David E Sanin , Elizabeth A Thompson , D Marc Rosen , Susan L Dalrymple , Lizamma Antony , Yuhan Yang , Carolina Gomes-Alexandre , Jessica L Hicks , Tracy Jones , Kiara A Bowers , Jillian N Eskra , Jennifer Meyers , Anuj Gupta , Alyza Skaist , Srinivasan Yegnasubramanian , Jun Luo , W Nathaniel Brennen , Sushant K Kachhap , Emmanuel S Antonarakis , Angelo M De Marzo , John T Isaacs , Mark C Markowski , Samuel R Denmeade

Targeting the fibroblast growth factor pathway in molecular subtypes of castration-resistant prostate cancer.

The Prostate

Avec: Mark P Labrecque , Lisha G Brown , Ilsa M Coleman , Holly M Nguyen , Susan Dalrymple , W Nathaniel Brennen , John T Isaacs , Dapei Li , Bryce Lakely , Diana C DeLucia , John K Lee , Michael T Schweizer , Daniel W Lin , Eva Corey , Peter S Nelson , Colm Morrissey

A hemi-spleen injection model of liver metastasis for prostate cancer.

The Prostate

Avec: Brian W Simons , Susan Dalrymple , Marc Rosen , Lei Zheng , W Nathaniel Brennen

Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors.

Oncogene

Avec: Yezi Zhu , Susan L Dalrymple , Ilsa Coleman , S Lilly Zheng , Jianfeng Xu , Jody E Hooper , Emmanuel S Antonarakis , Angelo M De Marzo , Alan K Meeker , Peter S Nelson , William B Isaacs , Samuel R Denmeade , Jun Luo , W Nathaniel Brennen , John T Isaacs

AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer.

Molecular cancer therapeutics

Avec: Mannan Nouri , Andreas Varkaris , Maya Ridinger , Susan L Dalrymple , Christopher M Dennehy , John T Isaacs , David J Einstein , W Nathaniel Brennen , Steven P Balk

Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling.

Molecular cancer research : MCR

Avec: Jin-Yih Low , W Nathaniel Brennen , Alan K Meeker , Elina Ikonen , Brian W Simons , Marikki Laiho

Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer.

JCI insight

Avec: W Nathaniel Brennen , Yezi Zhu , Ilsa M Coleman , Susan L Dalrymple , Lizamma Antony , Radhika A Patel , Brian Hanratty , Roshan Chikarmane , Alan K Meeker , S Lilly Zheng , Jody E Hooper , Jun Luo , Angelo M De Marzo , Eva Corey , Jianfeng Xu , Srinivasan Yegnasubramanian , Michael C Haffner , Peter S Nelson , William G Nelson , William B Isaacs , John T Isaacs

Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy.

Immunotherapy

Avec: W Nathaniel Brennen , Daniel L J Thorek , Wen Jiang , Timothy E Krueger , Lizamma Antony , Samuel R Denmeade , John T Isaacs

Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer.

Nature reviews. Urology

Avec: Joakin O Mori , Isra Elhussin , W Nathaniel Brennen , Mindy K Graham , Tamara L Lotan , Clayton C Yates , Angelo M De Marzo , Samuel R Denmeade , Srinivasan Yegnasubramanian , William G Nelson , Gerald V Denis , Elizabeth A Platz , Alan K Meeker , Christopher M Heaphy

LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer.

bioRxiv : the preprint server for biology

Avec: A Mandl , S Jasmine , Teg Krueger , R Kumar , I M Coleman , S L Dalrymple , L Antony , D M Rosen , Y Jing , B Hanratty , R A Patel , L Jin-Yih , J Dias , C A Celatka , A E Tapper , M Kleppe , M Kanayama , V Speranzini , Y Z Wang , J Luo , E Corey , L A Sena , R A Casero , T Lotan , B J Trock , S K Kachhap , S R Denmeade , M A Carducci , A Mattevi , M C Haffner , P S Nelson , H Y Rienhoff , J T Isaacs , W N Brennen

Defining the challenges and opportunities for using patient-derived models in prostate cancer research.

The Prostate

Avec: W Nathaniel Brennen , Clémentine Le Magnen , Sofia Karkampouna , Nicolas Anselmino , Nathalie Bock , Nicholas Choo , Ashlee K Clark , Ilsa M Coleman , Robin Dolgos , Alison M Ferguson , David L Goode , Marianna Krutihof-de Julio , Nora M Navone , Peter S Nelson , Edward O'Neill , Laura H Porter , Weranja Ranasinghe , Takuro Sunada , Elizabeth D Williams , Lisa M Butler , Eva Corey , Wytske M van Weerden , Renea A Taylor , Gail P Risbridger , Mitchell G Lawrence

The Hallmarks of Precancer.

Cancer discovery

Avec: Mary M Stangis , Zhengyi Chen , Jimin Min , Sarah E Glass , Jordan O Jackson , Megan D Radyk , Xen Ping Hoi , W Nathaniel Brennen , Ming Yu , Huy Q Dinh , Robert J Coffey , Martha J Shrubsole , Keith S Chan , William M Grady , Srinivasan Yegnasubramanian , Costas A Lyssiotis , Anirban Maitra , Richard B Halberg , Neelendu Dey , Ken S Lau

A novel method for detection of exfoliated prostate cancer cells in urine by RNA in situ hybridization.

Prostate cancer and prostatic diseases

Avec: Jillian N Eskra , Daniel Rabizadeh , Leslie Mangold , Elizabeth Fabian , W Nathaniel Brennen , David B Yeater , Kenneth J Pienta , Alan W Partin , William B Isaacs , Christian P Pavlovich , Jun Luo

A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer.

Stem cells translational medicine

Avec: Michael T Schweizer , Hao Wang , Trinity J Bivalacqua , Alan W Partin , Su Jin Lim , Carolyn Chapman , Rehab Abdallah , Oren Levy , Neil A Bhowmick , Jeffrey M Karp , Angelo De Marzo , John T Isaacs , W Nathaniel Brennen , Samuel R Denmeade

Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer.

Cancer research

Avec: Rajendra Kumar , Janet Mendonca , Olutosin Owoyemi , Kavya Boyapati , Naiju Thomas , Suthicha Kanacharoen , Max Coffey , Deven Topiwala , Carolina Gomes , Busra Ozbek , Tracy Jones , Marc Rosen , Liang Dong , Sadie Wiens , W Nathaniel Brennen , John T Isaacs , Angelo M De Marzo , Mark C Markowski , Emmanuel S Antonarakis , David Z Qian , Kenneth J Pienta , Drew M Pardoll , Michael A Carducci , Samuel R Denmeade , Sushant K Kachhap

Mipsagargin: The Beginning-Not the End-of Thapsigargin Prodrug-Based Cancer Therapeutics.

Molecules (Basel, Switzerland)

Avec: John T Isaacs , William Nathaniel Brennen , Søren Brøgger Christensen , Samuel R Denmeade

Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Hawley C Pruitt , Ya Guan , Hudson Liu , Alexis E Carey , W Nathaniel Brennen , Jiayun Lu , Corrine Joshu , Ashani Weeraratna , Tamara L Lotan , T S Karin Eisinger-Mathason , Sharon Gerecht

Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer.

The Prostate

Avec: John T Isaacs , Susan L Dalrymple , Lizamma Antony , David Marc Rosen , Ilsa M Coleman , Peter S Nelson , Maya Kostova , Iain A Murray , Gary H Perdew , Samuel R Denmeade , Emmanuel S Akinboye , W Nathaniel Brennen

Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.

The Journal of pathology

Avec: Radhika A Patel , Erolcan Sayar , Ilsa Coleman , Martine P Roudier , Brian Hanratty , Jin-Yih Low , Neha Jaiswal , Azra Ajkunic , Ruth Dumpit , Caner Ercan , Nina Salama , Valerie P O'Brien , William B Isaacs , Jonathan I Epstein , Angelo M De Marzo , Bruce J Trock , Jun Luo , W Nathaniel Brennen , Maria Tretiakova , Funda Vakar-Lopez , Lawrence D True , David W Goodrich , Eva Corey , Colm Morrissey , Peter S Nelson , Paula J Hurley , Roman Gulati , Michael C Haffner

Overexpression of Fibroblast Activation Protein (FAP) in stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate.

medRxiv : the preprint server for health sciences

Avec: Fernanda Caramella-Pereira , Qizhi Zheng , Jessica L Hicks , Sujayita Roy , Tracy Jones , Martin Pomper , Lizamma Antony , Alan K Meeker , Srinivasan Yegnasubramanian , Angelo M De Marzo , W Nathaniel Brennen

Réseau de co-auteurs

John T Isaacs 14 collaborations

Samuel R Denmeade 10 collaborations

Angelo M De Marzo 8 collaborations

Alan K Meeker 6 collaborations

Lizamma Antony 6 collaborations

Susan L Dalrymple 6 collaborations

Peter S Nelson 6 collaborations

Srinivasan Yegnasubramanian 5 collaborations

Jun Luo 5 collaborations

Daniel L J Thorek 4 collaborations

Kenneth J Pienta 4 collaborations

Brian W Simons 4 collaborations

Ilsa M Coleman 4 collaborations

Eva Corey 4 collaborations

William B Isaacs 4 collaborations

Michael C Haffner 3 collaborations

Tracy Jones 3 collaborations

Emmanuel S Antonarakis 3 collaborations

Timothy E Krueger 2 collaborations

Amber E de Groot 2 collaborations

Kayla V Myers 2 collaborations

Timothy E G Krueger 2 collaborations

Sarah R Amend 2 collaborations

Paula J Hurley 2 collaborations

Emmanuel S Akinboye 2 collaborations

Oren Levy 2 collaborations

D Marc Rosen 2 collaborations

Lei Zheng 2 collaborations

Jeffrey M Karp 2 collaborations

Rajendra Kumar 2 collaborations

Jessica L Hicks 2 collaborations

Jillian N Eskra 2 collaborations

Sushant K Kachhap 2 collaborations

Mark C Markowski 2 collaborations

Susan Dalrymple 2 collaborations

Michael T Schweizer 2 collaborations

Colm Morrissey 2 collaborations

Marc Rosen 2 collaborations

Yezi Zhu 2 collaborations

Ilsa Coleman 2 collaborations

S Lilly Zheng 2 collaborations

Jianfeng Xu 2 collaborations

Jody E Hooper 2 collaborations

Jin-Yih Low 2 collaborations

Radhika A Patel 2 collaborations

Brian Hanratty 2 collaborations

William G Nelson 2 collaborations

Tamara L Lotan 2 collaborations

Alan W Partin 2 collaborations

Peng Lu 1 collaboration

Karolyn A Oetjen 1 collaboration

Diane E Bender 1 collaboration

Marianna B Ruzinova 1 collaboration

Daniel A C Fisher 1 collaboration

Kevin G Shim 1 collaboration

Russell K Pachynski 1 collaboration

Stephen T Oh 1 collaboration

Daniel C Link 1 collaboration

Jesus Pacheco-Torres 1 collaboration

Raj Kumar Sharma 1 collaboration

Yelena Mironchik 1 collaboration

Flonne Wildes 1 collaboration

Dmitri Artemov 1 collaboration

Balaji Krishnamachary 1 collaboration

Zaver M Bhujwalla 1 collaboration

Ashley L Kiemen 1 collaboration

Natalia H Nagy 1 collaboration

Alexandria Brame 1 collaboration

Vicente E Torres 1 collaboration

Zhongyuan Zhang 1 collaboration

Levent Trabzonlu 1 collaboration

Denis Wirtz 1 collaboration

Robert M Hughes 1 collaboration

Hamda Khan 1 collaboration

Rebecca Miller 1 collaboration

Valentina Kugler 1 collaboration

Samantha Torquato 1 collaboration

Debebe Theodros 1 collaboration

Tamara Lotan 1 collaboration

Jessie Huang 1 collaboration

Elai Davicioni 1 collaboration

Steven S An 1 collaboration

Ryan C Riddle 1 collaboration

Isla P Garraway 1 collaboration

Elana J Fertig 1 collaboration

Ben H Park 1 collaboration

Oliver C Rogers 1 collaboration

Nitin Joshi 1 collaboration

Andrew Pickering 1 collaboration

Haoyue Lan 1 collaboration

Heidi Kuang 1 collaboration

Sudhir H Ranganath 1 collaboration

S Peter Howard 1 collaboration

Laura A Sena 1 collaboration

David E Sanin 1 collaboration

Elizabeth A Thompson 1 collaboration

Yuhan Yang 1 collaboration

Carolina Gomes-Alexandre 1 collaboration

Kiara A Bowers 1 collaboration

Jennifer Meyers 1 collaboration

Anuj Gupta 1 collaboration

Alyza Skaist 1 collaboration

Mark P Labrecque 1 collaboration

Lisha G Brown 1 collaboration

Holly M Nguyen 1 collaboration

Dapei Li 1 collaboration

Bryce Lakely 1 collaboration

Diana C DeLucia 1 collaboration

John K Lee 1 collaboration

Daniel W Lin 1 collaboration

Mannan Nouri 1 collaboration

Andreas Varkaris 1 collaboration

Maya Ridinger 1 collaboration

Christopher M Dennehy 1 collaboration

David J Einstein 1 collaboration

Steven P Balk 1 collaboration

Elina Ikonen 1 collaboration

Marikki Laiho 1 collaboration

Roshan Chikarmane 1 collaboration

Wen Jiang 1 collaboration

Joakin O Mori 1 collaboration

Isra Elhussin 1 collaboration

Mindy K Graham 1 collaboration

Clayton C Yates 1 collaboration

Gerald V Denis 1 collaboration

Elizabeth A Platz 1 collaboration

Christopher M Heaphy 1 collaboration

A Mandl 1 collaboration

S Jasmine 1 collaboration

Teg Krueger 1 collaboration

R Kumar 1 collaboration

I M Coleman 1 collaboration

S L Dalrymple 1 collaboration

L Antony 1 collaboration

D M Rosen 1 collaboration

Y Jing 1 collaboration

B Hanratty 1 collaboration

R A Patel 1 collaboration

L Jin-Yih 1 collaboration

J Dias 1 collaboration

C A Celatka 1 collaboration

A E Tapper 1 collaboration

M Kleppe 1 collaboration

M Kanayama 1 collaboration

V Speranzini 1 collaboration

Y Z Wang 1 collaboration

J Luo 1 collaboration

E Corey 1 collaboration

L A Sena 1 collaboration

R A Casero 1 collaboration

T Lotan 1 collaboration

B J Trock 1 collaboration

S K Kachhap 1 collaboration

S R Denmeade 1 collaboration

M A Carducci 1 collaboration

A Mattevi 1 collaboration

M C Haffner 1 collaboration

P S Nelson 1 collaboration

H Y Rienhoff 1 collaboration

J T Isaacs 1 collaboration

W N Brennen 1 collaboration

Clémentine Le Magnen 1 collaboration

Sofia Karkampouna 1 collaboration

Nicolas Anselmino 1 collaboration

Nathalie Bock 1 collaboration

Nicholas Choo 1 collaboration

Ashlee K Clark 1 collaboration

Robin Dolgos 1 collaboration

Alison M Ferguson 1 collaboration

David L Goode 1 collaboration

Marianna Krutihof-de Julio 1 collaboration

Nora M Navone 1 collaboration

Edward O'Neill 1 collaboration

Laura H Porter 1 collaboration

Weranja Ranasinghe 1 collaboration

Takuro Sunada 1 collaboration

Elizabeth D Williams 1 collaboration

Lisa M Butler 1 collaboration

Wytske M van Weerden 1 collaboration

Renea A Taylor 1 collaboration

Gail P Risbridger 1 collaboration

Mitchell G Lawrence 1 collaboration

Mary M Stangis 1 collaboration

Zhengyi Chen 1 collaboration

Jimin Min 1 collaboration

Sarah E Glass 1 collaboration

Jordan O Jackson 1 collaboration

Megan D Radyk 1 collaboration

Xen Ping Hoi 1 collaboration

Ming Yu 1 collaboration

Huy Q Dinh 1 collaboration

Robert J Coffey 1 collaboration

Martha J Shrubsole 1 collaboration

Keith S Chan 1 collaboration

William M Grady 1 collaboration

Costas A Lyssiotis 1 collaboration

Anirban Maitra 1 collaboration

Richard B Halberg 1 collaboration

Neelendu Dey 1 collaboration

Ken S Lau 1 collaboration

Daniel Rabizadeh 1 collaboration

Leslie Mangold 1 collaboration

Elizabeth Fabian 1 collaboration

David B Yeater 1 collaboration

Christian P Pavlovich 1 collaboration

Hao Wang 1 collaboration

Trinity J Bivalacqua 1 collaboration

Su Jin Lim 1 collaboration

Carolyn Chapman 1 collaboration

Rehab Abdallah 1 collaboration

Neil A Bhowmick 1 collaboration

Angelo De Marzo 1 collaboration

Janet Mendonca 1 collaboration

Olutosin Owoyemi 1 collaboration

Kavya Boyapati 1 collaboration

Naiju Thomas 1 collaboration

Suthicha Kanacharoen 1 collaboration

Max Coffey 1 collaboration

Deven Topiwala 1 collaboration

Carolina Gomes 1 collaboration

Busra Ozbek 1 collaboration

Liang Dong 1 collaboration

Sadie Wiens 1 collaboration

David Z Qian 1 collaboration

Drew M Pardoll 1 collaboration

Michael A Carducci 1 collaboration

William Nathaniel Brennen 1 collaboration

Søren Brøgger Christensen 1 collaboration

Hawley C Pruitt 1 collaboration

Ya Guan 1 collaboration

Hudson Liu 1 collaboration

Alexis E Carey 1 collaboration

Jiayun Lu 1 collaboration

Corrine Joshu 1 collaboration

Ashani Weeraratna 1 collaboration

T S Karin Eisinger-Mathason 1 collaboration

Sharon Gerecht 1 collaboration

David Marc Rosen 1 collaboration

Maya Kostova 1 collaboration

Iain A Murray 1 collaboration

Gary H Perdew 1 collaboration

Erolcan Sayar 1 collaboration

Martine P Roudier 1 collaboration

Neha Jaiswal 1 collaboration

Azra Ajkunic 1 collaboration

Ruth Dumpit 1 collaboration

Caner Ercan 1 collaboration

Nina Salama 1 collaboration

Valerie P O'Brien 1 collaboration

Jonathan I Epstein 1 collaboration

Bruce J Trock 1 collaboration

Maria Tretiakova 1 collaboration

Funda Vakar-Lopez 1 collaboration

Lawrence D True 1 collaboration

David W Goodrich 1 collaboration

Roman Gulati 1 collaboration

Fernanda Caramella-Pereira 1 collaboration

Qizhi Zheng 1 collaboration

Sujayita Roy 1 collaboration

Martin Pomper 1 collaboration