Treatment modalities and outcomes of granular cell tumors and spindle cell oncocytomas of the pituitary gland: an analysis of two national cancer databases.
Database
Granular Cell Tumor
Pituitary
Sella
Spindle Cell Oncocytoma
Journal
Acta neurochirurgica
ISSN: 0942-0940
Titre abrégé: Acta Neurochir (Wien)
Pays: Austria
ID NLM: 0151000
Informations de publication
Date de publication:
05 Apr 2024
05 Apr 2024
Historique:
received:
03
10
2023
accepted:
19
03
2024
medline:
8
4
2024
pubmed:
5
4
2024
entrez:
5
4
2024
Statut:
epublish
Résumé
Spindle cell oncocytomas (SCO) and granular cell tumors (GCT) are rare primary pituitary neoplasms; the optimal treatment paradigms for these lesions are unknown and largely unexplored. Thus, using national registries, we analyze the epidemiology, management patterns, and surgical outcomes of SCOs and GCTs. The National Cancer Database (NCDB; years 2003-2017) and the Surveillance, Epidemiology, and End Results Program (SEER; years 2004-2018) were queried for patients with pituitary SCOs or GCTs. Incidence, extent of surgical resection, and rate of postoperative radiation use for subtotally resected lesions comprised the primary outcomes of interest. All-cause mortality was also analyzed via time-to-event Kaplan-Meier curves. SCOs and GCTs have an annual incidence of 0.017 and 0.023 per 1,000,000, respectively. They comprise 0.1% of the benign pituitary tumors registered in NCDB. A total of 112,241 benign pituitary tumors were identified in NCDB during the study period, of which 83 (0.07%) were SCOs and 59 (0.05%) were GCTs. Median age at diagnosis was 55 years, 44% were females, and median maximal tumor diameter at presentation was 2.1 cm. Gross total resection was achieved in 54% patients. Ten patients (7%) had postoperative radiation. Comparing patients with GCTs versus SCOs, the former were more likely to be younger at diagnosis (48.0 vs. 59.0, respectively; p < 0.01) and female (59% vs. 34%, p = 0.01). GCTs and SCOs did not differ in terms of size at diagnoses (median maximal diameter: 1.9 cm vs. 2.2 cm, respectively; p = 0.59) or gross total resection rates (62% vs. 49%, p = 0.32). After matching SCOs and GCTs with pituitary adenomas on age, sex, and tumor size, the former were less likely to undergo gross total resection (53% vs. 72%; p = 0.03). Patients with SCOs and GCTs had a shorter overall survival when compared to patients with pituitary adenomas (p < 0.01) and a higher rate of thirty-day mortality (3.1% vs 0.0%; p = 0.013). SCOs and GCTs are rare pituitary tumors, and their management entails particular challenges. Gross total resection is often not possible, and adjuvant radiation might be employed following subtotal resection.
Sections du résumé
BACKGROUND
BACKGROUND
Spindle cell oncocytomas (SCO) and granular cell tumors (GCT) are rare primary pituitary neoplasms; the optimal treatment paradigms for these lesions are unknown and largely unexplored. Thus, using national registries, we analyze the epidemiology, management patterns, and surgical outcomes of SCOs and GCTs.
METHODS
METHODS
The National Cancer Database (NCDB; years 2003-2017) and the Surveillance, Epidemiology, and End Results Program (SEER; years 2004-2018) were queried for patients with pituitary SCOs or GCTs. Incidence, extent of surgical resection, and rate of postoperative radiation use for subtotally resected lesions comprised the primary outcomes of interest. All-cause mortality was also analyzed via time-to-event Kaplan-Meier curves.
RESULTS
RESULTS
SCOs and GCTs have an annual incidence of 0.017 and 0.023 per 1,000,000, respectively. They comprise 0.1% of the benign pituitary tumors registered in NCDB. A total of 112,241 benign pituitary tumors were identified in NCDB during the study period, of which 83 (0.07%) were SCOs and 59 (0.05%) were GCTs. Median age at diagnosis was 55 years, 44% were females, and median maximal tumor diameter at presentation was 2.1 cm. Gross total resection was achieved in 54% patients. Ten patients (7%) had postoperative radiation. Comparing patients with GCTs versus SCOs, the former were more likely to be younger at diagnosis (48.0 vs. 59.0, respectively; p < 0.01) and female (59% vs. 34%, p = 0.01). GCTs and SCOs did not differ in terms of size at diagnoses (median maximal diameter: 1.9 cm vs. 2.2 cm, respectively; p = 0.59) or gross total resection rates (62% vs. 49%, p = 0.32). After matching SCOs and GCTs with pituitary adenomas on age, sex, and tumor size, the former were less likely to undergo gross total resection (53% vs. 72%; p = 0.03). Patients with SCOs and GCTs had a shorter overall survival when compared to patients with pituitary adenomas (p < 0.01) and a higher rate of thirty-day mortality (3.1% vs 0.0%; p = 0.013).
CONCLUSION
CONCLUSIONS
SCOs and GCTs are rare pituitary tumors, and their management entails particular challenges. Gross total resection is often not possible, and adjuvant radiation might be employed following subtotal resection.
Identifiants
pubmed: 38578465
doi: 10.1007/s00701-024-06054-6
pii: 10.1007/s00701-024-06054-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
169Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
Références
Ahmed AK, Dawood HY, Penn DL, Smith TR (2017) Extent of surgical resection and tumor size predicts prognosis in granular cell tumor of the sellar region. Acta Neurochir (Wien) 159:2209–2216. https://doi.org/10.1007/s00701-017-3337-3
doi: 10.1007/s00701-017-3337-3
pubmed: 28948361
Ahmed AK, Dawood HY, Cote DJ, Bale TA, De Girolami U, Laws ER Jr, Smith TR (2019) Surgical resection of granular cell tumor of the sellar region: three indications. Pituitary 22:633–639. https://doi.org/10.1007/s11102-019-00999-z
doi: 10.1007/s11102-019-00999-z
pubmed: 31620953
pmcid: 8080114
Alvi MA, Wahood W, Huang AE, Kerezoudis P, Lachance DH, Bydon M (2019) Beyond Science: Effect of Marital Status and Socioeconomic Index on Outcomes of Spinal Cord Tumors: Analysis From a National Cancer Registry. World Neurosurg 121:e333–e343. https://doi.org/10.1016/j.wneu.2018.09.103
doi: 10.1016/j.wneu.2018.09.103
pubmed: 30261382
Aquilina K, Kamel M, Kalimuthu SG, Marks JC, Keohane C (2006) Granular cell tumour of the neurohypophysis: a rare sellar tumour with specific radiological and operative features. Br J Neurosurg 20:51–54. https://doi.org/10.1080/02688690600600996
doi: 10.1080/02688690600600996
pubmed: 16698612
Banerjee S, Zhao B, Sicklick JK, Aslam S, Burgoyne AM, Kelly KJ (2021) Commission on Cancer Facility Type is Associated with Overall Survival in Patients with Gastric Adenocarcinoma in the United States. Ann Surg Oncol 28:2846–2855. https://doi.org/10.1245/s10434-020-09422-5
doi: 10.1245/s10434-020-09422-5
pubmed: 33389292
Barresi V, Simbolo M, Gessi M, Rossi S, Caffo M, Eccher A, Angileri FF, Cannavò S, Brunelli M, Scarpa A (2021) Clinical-Pathological, Immunohistochemical, and Genetic Characterization of a Series of Posterior Pituitary Tumors. J Neuropathol Exp Neurol 80:45–51. https://doi.org/10.1093/jnen/nlaa139
doi: 10.1093/jnen/nlaa139
pubmed: 33212494
Benites Filho PR, Sakamoto D, Machuca TN, Serapião MJ, Ditzel L, Bleggi Torres LF (2005) Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation. Virchows Arch 447:649–652. https://doi.org/10.1007/s00428-005-1229-z
doi: 10.1007/s00428-005-1229-z
pubmed: 16133355
Bello CT, Cipriano P, Henriques V, Duarte JS, Marques CC (2018) Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism. Endocrinol Diabetes Metab Case Rep 2018. https://doi.org/10.1530/edm-17-0178
Billeci D, Marton E, Giordan E, Carraro V, Ronzon M, Rossi S (2017) Spindle cell oncocytoma: Report of two cases with massive bleeding and review of the literature. J Clin Neurosci 39:39–44. https://doi.org/10.1016/j.jocn.2017.02.017
doi: 10.1016/j.jocn.2017.02.017
pubmed: 28286028
Borg A, Jaunmuktane Z, Dorward N (2020) Tumors of the Neurohypophysis: One Unit’s Experience and Literature Review. World Neurosurg 134:e968–e978. https://doi.org/10.1016/j.wneu.2019.11.043
doi: 10.1016/j.wneu.2019.11.043
pubmed: 31734425
Brat DJ, Scheithauer BW, Staugaitis SM, Holtzman RN, Morgello S, Burger PC (2000) Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol 24:362–368. https://doi.org/10.1097/00000478-200003000-00004
doi: 10.1097/00000478-200003000-00004
pubmed: 10716149
Bubl R, Hugo HH, Hempelmann RG, Barth H, Mehdorn HM (2001) Granular-cell tumour: a rare suprasellar mass. Neuroradiology 43:309–312. https://doi.org/10.1007/s002340000507
doi: 10.1007/s002340000507
pubmed: 11338415
Chang CN, Shen CC (2022) Spindle cell oncocytoma of the pituitary tumor: A rare case report and literature reviews. Front Surg 9:1021680. https://doi.org/10.3389/fsurg.2022.1021680
doi: 10.3389/fsurg.2022.1021680
pubmed: 36793516
Cho HJ, Kim H, Kwak YJ, Seo JW, Paek SH, Sohn CH, Yun JM, Kim DS, Kang P, Park P, Park SH (2014) Clinicopathologic analysis of pituitary adenoma: a single institute experience. J Korean Med Sci 29:405–410. https://doi.org/10.3346/jkms.2014.29.3.405
doi: 10.3346/jkms.2014.29.3.405
pubmed: 24616591
pmcid: 3945137
Cohen-Gadol AA, Pichelmann MA, Link MJ, Scheithauer BW, Krecke KN, Young WF Jr, Hardy J, Giannini C (2003) Granular cell tumor of the sellar and suprasellar region: clinicopathologic study of 11 cases and literature review. Mayo Clin Proc 78:567–573. https://doi.org/10.4065/78.5.567
doi: 10.4065/78.5.567
pubmed: 12744543
Cole TS, Potla S, Sarris CE, Przybylowski CJ, Baranoski JF, Mooney MA, Barranco FD, White WL, Eschbacher JM, Little AS (2019) Rare Thyroid Transcription Factor 1-Positive Tumors of the Sellar Region: Barrow Neurological Institute Retrospective Case Series. World Neurosurg 129:e294–e302. https://doi.org/10.1016/j.wneu.2019.05.132
doi: 10.1016/j.wneu.2019.05.132
pubmed: 31132506
Cossu G, Brouland JP, La Rosa S, Camponovo C, Viaroli E, Daniel RT, Messerer M (2019) Comprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature. Endocr Pathol 30:219–236. https://doi.org/10.1007/s12022-019-09581-6
doi: 10.1007/s12022-019-09581-6
pubmed: 31209729
Cote DJ, Wiemann R, Smith TR, Dunn IF, Al-Mefty O, Laws ER (2015) The Expanding Spectrum of Disease Treated by the Transnasal, Transsphenoidal Microscopic and Endoscopic Anterior Skull Base Approach: A Single-Center Experience 2008–2015. World Neurosurg 84:899–905. https://doi.org/10.1016/j.wneu.2015.05.019
doi: 10.1016/j.wneu.2015.05.019
pubmed: 26008142
Covington MF, Chin SS, Osborn AG (2011) Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol 32:2067–2072. https://doi.org/10.3174/ajnr.A2717
doi: 10.3174/ajnr.A2717
pubmed: 21960498
pmcid: 7964422
Cummings TJ, Bentley RC, McLendon RE (2001) Pathologic quiz case: pituitary mass in a 48-year-old woman. Arch Pathol Lab Med 125:299–300. https://doi.org/10.5858/2001-125-0299-pqcpmi
doi: 10.5858/2001-125-0299-pqcpmi
pubmed: 11175658
Das L, Vaiphei K, Rai A, Ahuja CK, Singh P, Mohapatra I, Chhabra R, Bhansali A, Radotra BD, Grossman AB, Korbonits M, Dutta P (2021) Posterior pituitary tumours: patient outcomes and determinants of disease recurrence or persistence. Endocr Connect 10:387–400. https://doi.org/10.1530/ec-20-0621
doi: 10.1530/ec-20-0621
pubmed: 33709954
pmcid: 8142326
Dottermusch M, Rotermund R, Ricklefs FL, Wefers AK, Saeger W, Flitsch J, Glatzel M, Matschke J (2022) The Diagnostic Impact of Epigenomics in Pituicyte-derived Tumors: Report of an Unusual Sellar Lesion with Extensive Hemorrhage and Necrotic Debris. Endocr Pathol 33:411–413. https://doi.org/10.1007/s12022-022-09727-z
doi: 10.1007/s12022-022-09727-z
pubmed: 35921032
pmcid: 9420089
Faramand A, Kano H, Flickinger JC, Gardner P, Lunsford LD (2018) A Case of Symptomatic Granular Cell Tumor of the Pituitary Treated with Stereotactic Radiosurgery. Stereotact Funct Neurosurg 96:197–203. https://doi.org/10.1159/000489221
doi: 10.1159/000489221
pubmed: 30045031
Feng Z, Mao Z, Wang Z, Liao B, Zhu Y, Wang H (2020) Non-adenomatous pituitary tumours mimicking functioning pituitary adenomas. Br J Neurosurg 34:487–491. https://doi.org/10.1080/02688697.2018.1464121
doi: 10.1080/02688697.2018.1464121
pubmed: 29667493
Feng J, Duan Z, Yao K, Gui Q, Liu X, Wang X, Du Z, Shao L, Zhang B, Cai S, Zhu M, Ma Z, Hu Z, Xiang L, Fan X, Qi X (2023) Primary papillary epithelial tumor of the sella and posterior pituitary tumor show similar (epi)genetic features and constitute a single neuro-oncological entity. Neuro Oncol 25:1487–1497. https://doi.org/10.1093/neuonc/noad067
doi: 10.1093/neuonc/noad067
pubmed: 37058118
pmcid: 10398802
Fortin SP, Johnston SS, Schuemie MJ (2021) Applied comparison of large-scale propensity score matching and cardinality matching for causal inference in observational research. BMC Med Res Methodol 21:109. https://doi.org/10.1186/s12874-021-01282-1
doi: 10.1186/s12874-021-01282-1
pubmed: 34030640
pmcid: 8146256
Gagliardi F, Losa M, Boari N, Franzin A, Pozzobon G, Weber G, Mortini P (2013) Suprasellar granular cell tumor of the neurohypophysis in a child: unusual presentation in pediatric age of a rare tumor. Childs Nerv Syst 29:1031–1034. https://doi.org/10.1007/s00381-013-2062-3
doi: 10.1007/s00381-013-2062-3
pubmed: 23463129
Gagliardi F, Spina A, Barzaghi LR, Bailo M, Losa M, Terreni MR, Mortini P (2016) Suprasellar granular cell tumor of the neurohypophysis: surgical outcome of a very rare tumor. Pituitary 19:277–285. https://doi.org/10.1007/s11102-016-0704-7
doi: 10.1007/s11102-016-0704-7
pubmed: 26753850
Giantini Larsen AM, Cote DJ, Zaidi HA, Bi WL, Schmitt PJ, Iorgulescu JB, Miller MB, Smith TR, Lopes MB, Jane JA, Laws ER (2018) Spindle cell oncocytoma of the pituitary gland. J Neurosurg 131:517–525. https://doi.org/10.3171/2018.4.Jns18211
doi: 10.3171/2018.4.Jns18211
pubmed: 30485213
Goulart CR, Upadhyay S, Ditzel Filho LFS, Beer-Furlan A, Carrau RL, Prevedello LM, Prevedello DM (2017) Newly Diagnosed Sellar Tumors in Patients with Cancer: A Diagnostic Challenge and Management Dilemma. World Neurosurg 106:254–265. https://doi.org/10.1016/j.wneu.2017.06.139
doi: 10.1016/j.wneu.2017.06.139
pubmed: 28673886
Gregoire A, Bosschaert P, Godfraind C (2015) Granular Cell Tumor of the Pituitary Stalk: A Rare and Benign Entity. J Belg Soc Radiol 99:79–81. https://doi.org/10.5334/jbr-btr.841
doi: 10.5334/jbr-btr.841
pubmed: 30039073
pmcid: 6032804
Guerrero-Pérez F, Vidal N, Marengo AP, Pozo CD, Blanco C, Rivero-Celada D, Díez JJ, Iglesias P, Picó A, Villabona C (2019) Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series. Endocrine 63:36–43. https://doi.org/10.1007/s12020-018-1774-2
doi: 10.1007/s12020-018-1774-2
pubmed: 30276594
Hagel C, Buslei R, Buchfelder M, Fahlbusch R, Bergmann M, Giese A, Flitsch J, Lüdecke DK, Glatzel M, Saeger W (2017) Immunoprofiling of glial tumours of the neurohypophysis suggests a common pituicytic origin of neoplastic cells. Pituitary 20:211–217. https://doi.org/10.1007/s11102-016-0762-x
doi: 10.1007/s11102-016-0762-x
pubmed: 27744503
Halbauer DJ, Mészáros I, Dóczi T, Kajtár P, Pajor L, Kovács K, Gömöri E (2003) Rare sellar region tumors. Pathol Oncol Res 9:134–137. https://doi.org/10.1007/bf03033759
doi: 10.1007/bf03033759
pubmed: 12858221
Han F, Gao L, Wang Y, Jin Y, Lv Y, Yao Z, Zhang J (2018) Clinical and imaging features of granular cell tumor of the neurohypophysis: A retrospective analysis. Medicine (Baltimore) 97:e9745. https://doi.org/10.1097/md.0000000000009745
doi: 10.1097/md.0000000000009745
pubmed: 29489677
Hasegawa H, Van Gompel JJ, Oushy SH, Pollock BE, Link MJ, Meyer FB, Bancos I, Erickson D, Davidge-Pitts CJ, Little JT, Uhm JH, Swanson AA, Giannini C, Mahajan A, Atkinson JL (2021) A Comprehensive Study of Spindle Cell Oncocytoma of the Pituitary Gland: Series of 6 Cases and Meta-Analysis of 85 Cases. World Neurosurg 149:e197–e216. https://doi.org/10.1016/j.wneu.2021.02.051
doi: 10.1016/j.wneu.2021.02.051
pubmed: 33610869
Hong CS, Elsamadicy AA, Fisayo A, Inzucchi SE, Gopal PP, Vining EM, Erson-Omay EZ, Bulent Omay S (2021) Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report. Front Endocrinol (Lausanne) 12:762095. https://doi.org/10.3389/fendo.2021.762095
doi: 10.3389/fendo.2021.762095
pubmed: 34925233
Iglesias P, Guerrero-Pérez F, Villabona C, Díez JJ (2020) Adenohypophyseal hyperfunction syndromes and posterior pituitary tumors: prevalence, clinical characteristics, and pathophysiological mechanisms. Endocrine 70:15–23. https://doi.org/10.1007/s12020-020-02399-x
doi: 10.1007/s12020-020-02399-x
pubmed: 32613546
Jian F, Bian L, Sun S, Yang J, Chen X, Chen Y, Ma Q, Miao F, Wang W, Ning G, Sun Q (2014) Surgical biopsies in patients with central diabetes insipidus and thickened pituitary stalks. Endocrine 47:325–335. https://doi.org/10.1007/s12020-014-0184-3
doi: 10.1007/s12020-014-0184-3
pubmed: 24532100
Jiang B, Shi X, Fan C (2018) Sellar and suprasellar granular cell tumor of the neurohypophysis: A rare case report and review of the literature. Neuropathology 38:293–299. https://doi.org/10.1111/neup.12448
doi: 10.1111/neup.12448
pubmed: 29271018
Kandregula S, Shashidhar A, Rao S, Beniwal M, Shukla D, Srinivas D, Saini J, Mahadevan A, Santosh V, Arimappamagan A (2022) Granular Cell Tumor and Spindle Cell Oncocytoma of the Pituitary Gland: Imaging and Intraoperative Cytology Diagnostic Dilemmas and Management Challenges. J Neurol Surg A Cent Eur Neurosurg 83:442–450. https://doi.org/10.1055/s-0041-1740264
doi: 10.1055/s-0041-1740264
pubmed: 34911085
Kasashima S, Oda Y, Nozaki J, Shirasaki M, Nakanishi I (2000) A case of atypical granular cell tumor of the neurohypophysis. Pathol Int 50:568–573. https://doi.org/10.1046/j.1440-1827.2000.01080.x
doi: 10.1046/j.1440-1827.2000.01080.x
pubmed: 10886742
Khurana U, Shrivastava A, Jain R, Goel G, Joshi D, Kapoor N (2021) Squash smear cytology of pituitary granular cell tumor: A case report and review of literature with special emphasis on cytological differential diagnosis in pituitary region. Diagn Cytopathol 49:E119-e124. https://doi.org/10.1002/dc.24612
doi: 10.1002/dc.24612
pubmed: 32926559
Kim DJ, Lee S, Kim MS, Hwang JH, Hahm MH (2021) Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features. J Pathol Transl Med 55:225–229. https://doi.org/10.4132/jptm.2021.01.27
doi: 10.4132/jptm.2021.01.27
pubmed: 33677954
pmcid: 8141972
Kisiel M, Reddy KKV, Provias J, Whitton AC, Lu JQ (2023) Spindle cell oncocytoma reclassified from amelanotic melanocytoma of the sellar region. Clin Neuropathol 42:197–200. https://doi.org/10.5414/np301550
doi: 10.5414/np301550
pubmed: 37382339
Kleinschmidt-DeMasters BK, Lopes MB (2013) Update on hypophysitis and TTF-1 expressing sellar region masses. Brain Pathol 23:495–514. https://doi.org/10.1111/bpa.12068
doi: 10.1111/bpa.12068
pubmed: 23701182
pmcid: 8029353
Kunihiro J, Inoue A, Miyake T, Ohno T, Kitazawa R, Kunieda T (2023) Clinicopathological features and endoscopic findings of spindle cell oncocytoma: A case report and review of the literature. Int J Surg Case Rep 109:108536. https://doi.org/10.1016/j.ijscr.2023.108536
doi: 10.1016/j.ijscr.2023.108536
pubmed: 37487353
pmcid: 10369474
Kusakawa A, Inoue A, Nakamura Y, Nishida N, Fukushima M, Senba H, Suehiro S, Matsumoto S, Nishikawa M, Ozaki S, Shigekawa S, Watanabe H, Matsuura B, Kitazawa R, Kunieda T (2020) Clinical features and endoscopic findings of granular cell tumor of the sellar region: A case report and review of the literature. Surg Neurol Int 11:101. https://doi.org/10.25259/sni_111_2020
doi: 10.25259/sni_111_2020
pubmed: 32494380
pmcid: 7265469
Lee EB, Tihan T, Scheithauer BW, Zhang PJ, Gonatas NK (2009) Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker? J Neuropathol Exp Neurol 68:482–488. https://doi.org/10.1097/NEN.0b013e3181a13fca
doi: 10.1097/NEN.0b013e3181a13fca
pubmed: 19525896
Lettau M, Munk R (2014) Granular cell tumor of the infundibulum. Rofo 186:805–806. https://doi.org/10.1055/s-0033-1356188
doi: 10.1055/s-0033-1356188
pubmed: 24407708
Li P, Yang Z, Wang Z, Zhou Q, Li S, Wang X, Wang B, Zhao F, Liu P (2016) Granular cell tumors in the central nervous system: a report on eight cases and a literature review. Br J Neurosurg 30:611–618. https://doi.org/10.1080/02688697.2016.1181152
doi: 10.1080/02688697.2016.1181152
pubmed: 27188824
Liu HL, Huang BY, Zhang MS, Wang HR, Qu YM, Yu CJ (2017) Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis. Chin Med J (Engl) 130:741–743. https://doi.org/10.4103/0366-6999.201605
doi: 10.4103/0366-6999.201605
pubmed: 28303860
Lopez G, Pescia C, Galli C, Bramerio M, Tosoni A, Nebuloni M, Ferrara M, Bertani G, Caschera L, Triulzi FM, Locatelli M, Tabano S, Croci GA (2023) Granular cell tumor of the neurohypophysis presenting as a third ventricle mass. Neuropathology 43:472–478. https://doi.org/10.1111/neup.12907
doi: 10.1111/neup.12907
pubmed: 37147874
López-Muñoz B, Silva Ortega S, Sánchez Ortiga R, Aranda López I, Picó Alfonso A (2021) Concurrent corticotroph pituitary tumor and granular cell tumor: A very uncommon association. Endocrinol Diabetes Nutr (Engl Ed) 68:591–593. https://doi.org/10.1016/j.endien.2021.11.007
doi: 10.1016/j.endien.2021.11.007
pubmed: 34872644
Maenhoudt W, Van Dorpe J, Vanhauwaert D (2020) Granular Cell Tumor of the Pituitary Presenting with Major Intraventricular Hemorrhage. World Neurosurg 140:60–62. https://doi.org/10.1016/j.wneu.2020.05.027
doi: 10.1016/j.wneu.2020.05.027
pubmed: 32407921
Menon G, Easwer HV, Radhakrishnan VV, Nair S (2008) Symptomatic granular cell tumour of the pituitary. Br J Neurosurg 22:126–130. https://doi.org/10.1080/02688690701604566
doi: 10.1080/02688690701604566
pubmed: 17952719
Mete O, Lopes MB, Asa SL (2013) Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Am J Surg Pathol 37:1694–1699. https://doi.org/10.1097/PAS.0b013e31829723e7
doi: 10.1097/PAS.0b013e31829723e7
pubmed: 23887161
Mohan A, Kannoth P, Unni C, Jose BV, Parambil RM, Nandeesh BN (2020) Rare neurohypophyseal tumor presenting as giant pituitary macroadenoma with cavernous sinus invasion - A case report and review of literature. Surg Neurol Int 11:261. https://doi.org/10.25259/sni_316_2020
doi: 10.25259/sni_316_2020
pubmed: 33024599
pmcid: 7533092
Molitch ME (2017) Diagnosis and Treatment of Pituitary Adenomas: A Review. JAMA 317:516–524. https://doi.org/10.1001/jama.2016.19699
doi: 10.1001/jama.2016.19699
pubmed: 28170483
Mumert ML, Walsh MT, Chin SS, Couldwell WT (2011) Cystic granular cell tumor mimicking Rathke cleft cyst. J Neurosurg 114:325–328. https://doi.org/10.3171/2010.5.Jns1058
doi: 10.3171/2010.5.Jns1058
pubmed: 20509726
Nail TJ, Araque JM, Vender J, Rojiani AM (2017) An 57-Year-Old Female with Sudden onset of Transient Right Homonymous Hemianopsia. Brain Pathol 27:691–692. https://doi.org/10.1111/bpa.12539
doi: 10.1111/bpa.12539
pubmed: 28805006
pmcid: 8029464
Orning JL, Trembath DG, Zanation AM, Germanwala AV (2013) Endoscopic Endonasal Approach for Resection of Infundibular Granular Cell Tumor: Case Report and Literature Review. J Case Rep Med 2:235775. https://doi.org/10.4303/jcrm/235775
doi: 10.4303/jcrm/235775
pubmed: 24860674
pmcid: 4030550
Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS (2021) CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014–2018. Neuro Oncol 23:iii1–iii105. https://doi.org/10.1093/neuonc/noab200
doi: 10.1093/neuonc/noab200
pubmed: 34608945
pmcid: 8491279
Oushy S, Graffeo CS, Perry A, Stafford SL, Link MJ, Pollock BE (2019) Single-fraction stereotactic radiosurgery for spindle cell oncocytoma: preliminary experience and systematic review of the literature. J Neurooncol 144:325–332. https://doi.org/10.1007/s11060-019-03231-x
doi: 10.1007/s11060-019-03231-x
pubmed: 31254265
Park SJ, Chang YH, Yang NR, Seo EK (2015) Granular cell tumor in the pituitary stalk: a case report. Brain Tumor Res Treat 3:60–63. https://doi.org/10.14791/btrt.2015.3.1.60
doi: 10.14791/btrt.2015.3.1.60
pubmed: 25977911
pmcid: 4426281
Pendharkar AV, Lin CY, Born DE, Hoffman AR, Dodd RL (2019) Granular Cell Pituitary Tumor in a Patient with Multiple Endocrine Neoplasia-1. Cureus 11:e4541. https://doi.org/10.7759/cureus.4541
doi: 10.7759/cureus.4541
pubmed: 31275768
pmcid: 6592835
Piccirilli M, Maiola V, Salvati M, D’Elia A, Di Paolo A, Campagna D, Santoro A, Delfini R (2014) Granular cell tumor of the neurohypophysis: a single-institution experience. Tumori 100:160e–164e. https://doi.org/10.1700/1636.17940
doi: 10.1700/1636.17940
pubmed: 25296610
Policarpio-Nicolas ML, Le BH, Mandell JW, Lopes MB (2008) Granular cell tumor of the neurohypophysis: report of a case with intraoperative cytologic diagnosis. Diagn Cytopathol 36:58–63. https://doi.org/10.1002/dc.20646
doi: 10.1002/dc.20646
pubmed: 18064694
Popovic V, Pekic S, Skender-Gazibara M, Salehi F, Kovacs K (2007) A large sellar granular cell tumor in a 21-year-old woman. Endocr Pathol 18:91–94. https://doi.org/10.1007/s12022-007-0013-9
doi: 10.1007/s12022-007-0013-9
pubmed: 17916999
Qiao N, Cheng H, Zhang Z, Ye H, Shen M, Shou X, Cao X, Chen H, Zhou X, Wang Y, Zhao Y (2022) Recommendation to improve the WHO classification of posterior pituitary tumors as a unique entity: evidence from a large case series. Endocr Connect 11. https://doi.org/10.1530/ec-22-0188
R Core Team (2022) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/
Rennert RC, Nadel JL, Budohoski KP, Couldwell WT (2022) Trans-lamina Terminalis Approach for Resection of Third Ventricular Tumor. World Neurosurg 160:33. https://doi.org/10.1016/j.wneu.2022.01.032
doi: 10.1016/j.wneu.2022.01.032
pubmed: 35051637
Rhee JS, Wackym PA, Hague K, Wolfe D, King WA (2002) Granular cell tumor of the pituitary fossa. Ann Otol Rhinol Laryngol 111:754–758. https://doi.org/10.1177/000348940211100818
doi: 10.1177/000348940211100818
pubmed: 12184601
Rickert CH, Kuchelmeister K, Gullotta F (1997) Morphological and immunohistochemical characterization of granular cells in non-hypophyseal tumours of the central nervous system. Histopathology 30:464–471. https://doi.org/10.1046/j.1365-2559.1997.5360788.x
doi: 10.1046/j.1365-2559.1997.5360788.x
pubmed: 9181368
Rodriguez FJ, Scheithauer BW, Roncaroli F, Silva AI, Kovacs K, Brat DJ, Jin L (2008) Galectin-3 expression is ubiquitous in tumors of the sellar region, nervous system, and mimics: an immunohistochemical and RT-PCR study. Am J Surg Pathol 32:1344–1352. https://doi.org/10.1097/PAS.0b013e3181694f41
doi: 10.1097/PAS.0b013e3181694f41
pubmed: 18670355
Roncaroli F, Scheithauer BW, Cenacchi G, Horvath E, Kovacs K, Lloyd RV, Abell-Aleff P, Santi M, Yates AJ (2002) “Spindle cell oncocytoma” of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol 26:1048–1055. https://doi.org/10.1097/00000478-200208000-00010
doi: 10.1097/00000478-200208000-00010
pubmed: 12170092
Rubino F, Martinez-Perez R, Vieira S, Voscoboinik DS, Mural M, Orr AJ, Hardesty DA, Carrau RL, Prevedello DM (2020) Granular cell tumors of the sellar region: what should be done after subtotal resection? A systematic review. Pituitary 23:721–732. https://doi.org/10.1007/s11102-020-01068-6
doi: 10.1007/s11102-020-01068-6
pubmed: 32740679
Rubino F, Eichberg DG, Saad AG, Komotar RJ, Ivan ME (2023) Synchronous Posterior and Anterior Pituitary Tumors: A Case Report of a Hypothetic Paracrine Relationship. Asian J Neurosurg 18:377–382. https://doi.org/10.1055/s-0043-1768601
doi: 10.1055/s-0043-1768601
pubmed: 37397038
pmcid: 10313437
Saeger W, von Schöning J, Flitsch J, Jautzke G, Bergmann M, Hagel C, Knappe UJ (2021) Co-occurrence of Pituitary Neuroendocrine Tumors (PitNETs) and Tumors of the Neurohypophysis. Endocr Pathol 32:473–479. https://doi.org/10.1007/s12022-021-09677-y
doi: 10.1007/s12022-021-09677-y
pubmed: 34129177
Saint-Blancard P, Pierre B, Philippe C, de Soultrait FR (2007) A rare case of diminished visual acuity: neurohypophyseal granular cell tumor. Neurochirurgie 53:296–298. https://doi.org/10.1016/j.neuchi.2007.05.004
doi: 10.1016/j.neuchi.2007.05.004
pubmed: 17585953
Sasazawa DT, Reis F, Queiroz LS, Rogério F, Garmes HM (2015) Granular cell tumor (GCT) mimicking a nonsecreting anterior pituitary adenoma. Arq Neuropsiquiatr 73:1045. https://doi.org/10.1590/0004-282x20150157
doi: 10.1590/0004-282x20150157
pubmed: 26465283
Schaller B, Kirsch E, Tolnay M, Mindermann T (1998) Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 42:166–170. https://doi.org/10.1097/00006123-199801000-00036 . (discussion 170-161)
doi: 10.1097/00006123-199801000-00036
pubmed: 9442519
Schöning JV, Flitsch J, Lüdecke DK, Fahlbusch R, Buchfelder M, Buslei R, Knappe UJ, Bergmann M, Schulz-Schaeffer WJ, Herms J, Glatzel M, Saeger W (2022) Multiple tumorous lesions of the pituitary gland. Hormones (Athens) 21:653–663. https://doi.org/10.1007/s42000-022-00392-9
doi: 10.1007/s42000-022-00392-9
pubmed: 35947342
Shizukuishi T, Abe O, Haradome H, Fukushima T, Katayama Y, Sugitani M (2014) Granular cell tumor of the neurohypophysis with optic tract edema. Jpn J Radiol 32:179–182. https://doi.org/10.1007/s11604-013-0279-4
doi: 10.1007/s11604-013-0279-4
pubmed: 24414885
Suzuki R, Takano S, Akutsu H, Satomi K, Morishita Y, Takahashi A, Noguchi M, Matsumura A (2012) Granular cell tumor of the neurohypophysis observed with hypoglycemic attack. No Shinkei Geka 40:723–728
pubmed: 22824579
Taka TM, Yang CY, Limbo JN, Chan AY, Davies J, Kuan EC, Turner SG, Hsu FPK (2021) Pituitary spindle cell oncocytoma: illustrative case. J Neurosurg Case Lessons 2. https://doi.org/10.3171/case21356
Talarico V, Giancotti L, Mazza GA, Galea E, Arcuri PP, Raiola G, Galati MC, Tucci L, Miniero R (2022) Multiple oral and cerebral relapses of a Granular cell tumor (Abrikossoff Tumor) in a young girl affected by congenital dyserythropoietic anemia type II. Clin Ter 173:35–38. https://doi.org/10.7417/ct.2022.2388
doi: 10.7417/ct.2022.2388
pubmed: 35147644
Tariciotti L, Arrichiello A, Fiore G, Bertani G, Conte G, Paolucci A, Ferrante E, Mantovani G, Locatelli M (2020) Arterial Embolization and Second-Look in Spindle Cell Oncocytoma of the Pituitary Gland: Case Report and Review of Literature. World Neurosurg 142:87–92. https://doi.org/10.1016/j.wneu.2020.05.255
doi: 10.1016/j.wneu.2020.05.255
pubmed: 32525090
Thakkar K, Ramteke-Jadhav S, Kasaliwal R, Memon SS, Patil V, Thadani P, Lomte N, Sankhe S, Goel A, Epari S, Goel N, Lila A, Shah NS, Bandgar T (2020) Sellar surprises: a single-centre experience of unusual sellar masses. Endocr Connect 9:111–121. https://doi.org/10.1530/ec-19-0497
doi: 10.1530/ec-19-0497
pubmed: 31910151
pmcid: 6993267
Trifa A, Knafo S, Maatoug A, Militaru M, Copaciu R, Aghakhani N, Parker F (2023) Surgical management of pituicytomas: a single-center case series. Acta Neurol Belg 123:815–822. https://doi.org/10.1007/s13760-022-01917-0
doi: 10.1007/s13760-022-01917-0
pubmed: 35301693
Tuleasca C, Daniel RT, Levivier M (2019) A rare case of pituitary oncocytoma successfully treated with single-fraction stereotactic Gamma Knife surgery. J Neurooncol 145:185–187. https://doi.org/10.1007/s11060-019-03270-4
doi: 10.1007/s11060-019-03270-4
pubmed: 31452070
Vajtai I, Sahli R, Kappeler A (2006) Spindle cell oncocytoma of the adenohypophysis: report of a case with a 16-year follow-up. Pathol Res Pract 202:745–750. https://doi.org/10.1016/j.prp.2006.05.008
doi: 10.1016/j.prp.2006.05.008
pubmed: 16884858
Vogelgesang S, Junge MH, Pahnke J, Gaab MR, Warzok RW (2002) August 2001: Sellar/suprasellar mass in a 59-year-old woman. Brain Pathol 12(135–136):139
pubmed: 11770897
Vuong HG, Nguyen TPX, Pham N, Dunn IF (2021) Risk factors for tumor recurrence and progression of spindle cell oncocytoma of the pituitary gland: a systematic review and pooled analysis. Pituitary 24:429–437. https://doi.org/10.1007/s11102-020-01110-7
doi: 10.1007/s11102-020-01110-7
pubmed: 33205233
Wilkinson MD, Fulham MJ, Besser M (2003) Neuroimaging findings in a suprasellar granular cell tumor. J Comput Assist Tomogr 27:26–29. https://doi.org/10.1097/00004728-200301000-00005
doi: 10.1097/00004728-200301000-00005
pubmed: 12544238
Witte HM, Riecke A, Saeger W, Hackenbroch C, Mathieu R, Mauer UM, Schulz C (2023) Spindle cell oncocytoma of the neurohypophysis with metastasis to the sphenoparietal sinus and immunohistochemical negativity for S100 and epithelial membrane antigen (EMA). Br J Neurosurg 37:641–646. https://doi.org/10.1080/02688697.2018.1533107
doi: 10.1080/02688697.2018.1533107
pubmed: 30431381
Yamamuro S, Homma T, Hanashima Y, Yoshimura S, Oshima H, Ohni S, Kusumi Y, Yoshino A (2017) A case of symptomatic granular cell tumor of the sellar region with large calcification. Neuropathology 37:371–374. https://doi.org/10.1111/neup.12378
doi: 10.1111/neup.12378
pubmed: 28276095
Yang GZ, Li J (2017) Granular Cell Tumor of the Neurohypophysis With TFE-3 Expression: A Rare Case Report. Int J Surg Pathol 25:751–754. https://doi.org/10.1177/1066896917712861
doi: 10.1177/1066896917712861
pubmed: 28612665
Zhang Y, Teng Y, Zhu H, Lu L, Deng K, Pan H, Yao Y (2018) Granular Cell Tumor of the Neurohypophysis: 3 Cases and a Systematic Literature Review of 98 Cases. World Neurosurg 118:e621–e630. https://doi.org/10.1016/j.wneu.2018.07.004
doi: 10.1016/j.wneu.2018.07.004
pubmed: 30017767