ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 Apr 2024
Historique:
received: 10 08 2023
accepted: 02 04 2024
medline: 11 4 2024
pubmed: 11 4 2024
entrez: 10 4 2024
Statut: aheadofprint

Résumé

Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores upon cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)

Identifiants

DOI: 10.1038/s41586-024-07373-5 PMID: 38599239
pubmed: 38599239
doi: 10.1038/s41586-024-07373-5
pii: 10.1038/s41586-024-07373-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

Auteurs

Gang Du (G)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0003-0805-4778

Liam B Healy (LB)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0002-2640-1596

Liron David (L)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. david@crystal.harvard.edu.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. david@crystal.harvard.edu.
Department of Life Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel. david@crystal.harvard.edu.
ORCID: 0000-0002-9750-543X

Caitlin Walker (C)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Seqirus, Cambridge, MA, USA.
ORCID: 0000-0003-0977-8276

Tarick J El-Baba (TJ)

Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Kavli Institute for NanoScience Discovery, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0003-4497-9938

Corinne A Lutomski (CA)

Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Kavli Institute for NanoScience Discovery, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0001-7509-103X

Byoungsook Goh (B)

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
ORCID: 0000-0002-7894-7259

Bowen Gu (B)

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-2629-9963

Xiong Pi (X)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0001-8835-6914

Pascal Devant (P)

Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0001-9743-6764

Pietro Fontana (P)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0003-3215-3784

Ying Dong (Y)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.

Xiyu Ma (X)

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Rui Miao (R)

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Arumugam Balasubramanian (A)

Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA, USA.
Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0002-7333-8542

Robbins Puthenveetil (R)

Section on Structural and Chemical Biology, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Anirban Banerjee (A)

Section on Structural and Chemical Biology, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-1494-6801

Hongbo R Luo (HR)

Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA, USA.
Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0002-8545-0451

Jonathan C Kagan (JC)

Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.
ORCID: 0000-0003-2364-2746

Sungwhan F Oh (SF)

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
ORCID: 0000-0002-0280-7903

Carol V Robinson (CV)

Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Kavli Institute for NanoScience Discovery, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0001-7829-5505

Judy Lieberman (J)

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6200-4715

Hao Wu (H)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. wu@crystal.harvard.edu.
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. wu@crystal.harvard.edu.
ORCID: 0000-0002-7281-8579

Classifications MeSH