Pascal Devant

Affiliations

Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt/Main, Germany.
Ph.D. Program in Virology, Harvard Medical School, Boston, MA, USA.
Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.

ORCID: 0000-0001-9743-6764

Publications (15)

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.

Nature communications

Avec: Samoil Sekulovski , Pascal Devant , Silvia Panizza , Tasos Gogakos , Anda Pitiriciu , Katharina Heitmeier , Ewan Phillip Ramsay , Marie Barth , Carla Schmidt , Thomas Tuschl , Frank Baas , Stefan Weitzer , Javier Martinez , Simon Trowitzsch

Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.

eLife

Avec: Jazlyn P Borges , Ragnhild S R Sætra , Allen Volchuk , Marit Bugge , Pascal Devant , Bjørnar Sporsheim , Bridget R Kilburn , Charles L Evavold , Jonathan C Kagan , Neil M Goldenberg , Trude Helen Flo , Benjamin Ethan Steinberg

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation.

bioRxiv : the preprint server for biology

Avec: Gang Du , Liam B Healy , Liron David , Caitlin Walker , Pietro Fontana , Ying Dong , Pascal Devant , Robbins Puthenveetil , Scott B Ficarro , Anirban Banerjee , Jonathan C Kagan , Judy Lieberman , Hao Wu

Structural insights into cytokine cleavage by inflammatory caspase-4.

Nature

Avec: Pascal Devant , Ying Dong , Julian Mintseris , Weiyi Ma , Steven P Gygi , Hao Wu , Jonathan C Kagan

Gasdermin D pore-forming activity is redox-sensitive.

Cell reports

Avec: Pascal Devant , Elvira Boršić , Elsy M Ngwa , Haopeng Xiao , Edward T Chouchani , Jay R Thiagarajah , Iva Hafner-Bratkovič , Charles L Evavold , Jonathan C Kagan

Structural transitions enable interleukin-18 maturation and signaling.

Immunity

Avec: Ying Dong , Jeffrey P Bonin , Pascal Devant , Zhuoyi Liang , Alexander I M Sever , Julian Mintseris , James M Aramini , Gang Du , Stephen P Gygi , Jonathan C Kagan , Lewis E Kay , Hao Wu

Correction of age-associated defects in dendritic cells enables CD4

Cell

Avec: Dania Zhivaki , Stephanie N Kennedy , Josh Park , Francesco Boriello , Pascal Devant , Anh Cao , Kristin M Bahleda , Shane Murphy , Cristin McCabe , Charles L Evavold , Kate L Chapman , Ivan Zanoni , Orr Ashenberg , Ramnik J Xavier , Jonathan C Kagan

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.

Cell

Avec: Charles L Evavold , Iva Hafner-Bratkovič , Pascal Devant , Jasmin M D'Andrea , Elsy M Ngwa , Elvira Boršić , John G Doench , Martin W LaFleur , Arlene H Sharpe , Jay R Thiagarajah , Jonathan C Kagan

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.

Science immunology

Avec: Arumugam Balasubramanian , Alan Y Hsu , Laxman Ghimire , Muhammad Tahir , Pascal Devant , Pietro Fontana , Gang Du , Xing Liu , Dang Fabin , Hiroto Kambara , Xuemei Xie , Fei Liu , Tomoya Hasegawa , Rong Xu , Hongbo Yu , Mei Chen , Steven Kolakowski , Sunia Trauger , Martin Røssel Larsen , Wenyi Wei , Hao Wu , Jonathan C Kagan , Judy Lieberman , Hongbo R Luo

Molecular mechanisms of gasdermin D pore-forming activity.

Nature immunology

Avec: Pascal Devant , Jonathan C Kagan

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β converting enzyme.

Science immunology

Avec: Pascal Devant , Anh Cao , Jonathan C Kagan

Engineering an Antibody V Gene-Selective Vaccine.

Frontiers in immunology

Avec: Larance Ronsard , Ashraf S Yousif , Julianne Peabody , Vintus Okonkwo , Pascal Devant , Alemu Tekewe Mogus , Ralston M Barnes , Daniel Rohrer , Nils Lonberg , David Peabody , Bryce Chackerian , Daniel Lingwood

Protocol to purify recombinant inflammatory caspases and assess their catalytic activity in vitro.

STAR protocols

Avec: Pascal Devant , Jonathan C Kagan

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.

Nature

Avec: Gang Du , Liam B Healy , Liron David , Caitlin Walker , Tarick J El-Baba , Corinne A Lutomski , Byoungsook Goh , Bowen Gu , Xiong Pi , Pascal Devant , Pietro Fontana , Ying Dong , Xiyu Ma , Rui Miao , Arumugam Balasubramanian , Robbins Puthenveetil , Anirban Banerjee , Hongbo R Luo , Jonathan C Kagan , Sungwhan F Oh , Carol V Robinson , Judy Lieberman , Hao Wu

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules.

bioRxiv : the preprint server for biology

Avec: Anh B Cao , Pascal Devant , Chengliang Wang , Mengyu Sun , Stephanie N Kennedy , Jianbin Ruan , Jonathan C Kagan

Réseau de co-auteurs

Jonathan C Kagan 13 collaborations

Hao Wu 5 collaborations

Charles L Evavold 4 collaborations

Gang Du 4 collaborations

Ying Dong 4 collaborations

Pietro Fontana 3 collaborations

Judy Lieberman 3 collaborations

Liam B Healy 2 collaborations

Liron David 2 collaborations

Caitlin Walker 2 collaborations

Robbins Puthenveetil 2 collaborations

Anirban Banerjee 2 collaborations

Julian Mintseris 2 collaborations

Elvira Boršić 2 collaborations

Elsy M Ngwa 2 collaborations

Jay R Thiagarajah 2 collaborations

Iva Hafner-Bratkovič 2 collaborations

Stephanie N Kennedy 2 collaborations

Anh Cao 2 collaborations

Arumugam Balasubramanian 2 collaborations

Hongbo R Luo 2 collaborations

Samoil Sekulovski 1 collaboration

Silvia Panizza 1 collaboration

Tasos Gogakos 1 collaboration

Anda Pitiriciu 1 collaboration

Katharina Heitmeier 1 collaboration

Ewan Phillip Ramsay 1 collaboration

Marie Barth 1 collaboration

Carla Schmidt 1 collaboration

Thomas Tuschl 1 collaboration

Frank Baas 1 collaboration

Stefan Weitzer 1 collaboration

Javier Martinez 1 collaboration

Simon Trowitzsch 1 collaboration

Jazlyn P Borges 1 collaboration

Ragnhild S R Sætra 1 collaboration

Allen Volchuk 1 collaboration

Marit Bugge 1 collaboration

Bjørnar Sporsheim 1 collaboration

Bridget R Kilburn 1 collaboration

Neil M Goldenberg 1 collaboration

Trude Helen Flo 1 collaboration

Benjamin Ethan Steinberg 1 collaboration

Scott B Ficarro 1 collaboration

Weiyi Ma 1 collaboration

Steven P Gygi 1 collaboration

Haopeng Xiao 1 collaboration

Edward T Chouchani 1 collaboration

Jeffrey P Bonin 1 collaboration

Zhuoyi Liang 1 collaboration

Alexander I M Sever 1 collaboration

James M Aramini 1 collaboration

Stephen P Gygi 1 collaboration

Lewis E Kay 1 collaboration

Dania Zhivaki 1 collaboration

Josh Park 1 collaboration

Francesco Boriello 1 collaboration

Kristin M Bahleda 1 collaboration

Shane Murphy 1 collaboration

Cristin McCabe 1 collaboration

Kate L Chapman 1 collaboration

Ivan Zanoni 1 collaboration

Orr Ashenberg 1 collaboration

Ramnik J Xavier 1 collaboration

Jasmin M D'Andrea 1 collaboration

John G Doench 1 collaboration

Martin W LaFleur 1 collaboration

Arlene H Sharpe 1 collaboration

Alan Y Hsu 1 collaboration

Laxman Ghimire 1 collaboration

Muhammad Tahir 1 collaboration

Xing Liu 1 collaboration

Dang Fabin 1 collaboration

Hiroto Kambara 1 collaboration

Xuemei Xie 1 collaboration

Fei Liu 1 collaboration

Tomoya Hasegawa 1 collaboration

Rong Xu 1 collaboration

Hongbo Yu 1 collaboration

Mei Chen 1 collaboration

Steven Kolakowski 1 collaboration

Sunia Trauger 1 collaboration

Martin Røssel Larsen 1 collaboration

Wenyi Wei 1 collaboration

Larance Ronsard 1 collaboration

Ashraf S Yousif 1 collaboration

Julianne Peabody 1 collaboration

Vintus Okonkwo 1 collaboration

Alemu Tekewe Mogus 1 collaboration

Ralston M Barnes 1 collaboration

Daniel Rohrer 1 collaboration

Nils Lonberg 1 collaboration

David Peabody 1 collaboration

Bryce Chackerian 1 collaboration

Daniel Lingwood 1 collaboration

Tarick J El-Baba 1 collaboration

Corinne A Lutomski 1 collaboration

Byoungsook Goh 1 collaboration

Bowen Gu 1 collaboration

Xiong Pi 1 collaboration

Xiyu Ma 1 collaboration

Rui Miao 1 collaboration

Sungwhan F Oh 1 collaboration

Carol V Robinson 1 collaboration

Anh B Cao 1 collaboration

Chengliang Wang 1 collaboration

Mengyu Sun 1 collaboration

Jianbin Ruan 1 collaboration