Neurofilament Light Chains in Systemic Amyloidosis: A Systematic Review.
autonomic neuropathy
biomarker
hereditary transthyretin amyloid
immunoglobulin light chain amyloid
neurofilament light chain
polyneuropathy
small fiber neuropathy
systemic amyloidosis
transthyretin gene-variant carrier
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Mar 2024
28 Mar 2024
Historique:
received:
17
02
2024
revised:
08
03
2024
accepted:
25
03
2024
medline:
13
4
2024
pubmed:
13
4
2024
entrez:
13
4
2024
Statut:
epublish
Résumé
Peripheral and autonomic neuropathy are common disease manifestations in systemic amyloidosis. The neurofilament light chain (NfL), a neuron-specific biomarker, is released into the blood and cerebrospinal fluid after neuronal damage. There is a need for an early and sensitive blood biomarker for polyneuropathy, and this systematic review provides an overview on the value of NfL in the early detection of neuropathy, central nervous system involvement, the monitoring of neuropathy progression, and treatment effects in systemic amyloidosis. A literature search in PubMed, Embase, and Web of Science was performed on 14 February 2024 for studies investigating NfL levels in patients with systemic amyloidosis and transthyretin gene-variant (
Identifiants
pubmed: 38612579
pii: ijms25073770
doi: 10.3390/ijms25073770
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM