Michael Polydefkis

Affiliations

Departments of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. mpolyde@jhmi.edu.

Publications (30)

Ethoxyquin is neuroprotective and partially prevents somatic and autonomic neuropathy in db/db mouse model of type 2 diabetes.

Scientific reports

Avec: Ying Liu , Yuan Sun , Osefame Ewaleifoh , Josh Wei , Ruifa Mi , Jing Zhu , Ahmet Hoke , Michael Polydefkis

Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria.

Neurology

Avec: Roy Freeman , Jennifer S Gewandter , Catharina G Faber , Christopher Gibbons , Simon Haroutounian , Giuseppe Lauria , Todd Levine , Rayaz A Malik , J Robinson Singleton , A Gordon Smith , Josh Bell , Robert H Dworkin , Eva Feldman , David N Herrmann , Ahmet Hoke , Noah Kolb , Heikki Mansikka , Anne Louise Oaklander , Amanda Peltier , Michael Polydefkis , Elissa Ritt , James W Russell , Stephen Sainati , Deborah Steiner , Roi Treister , Nurcan Üçeyler

Pain mechanisms in hereditary palmoplantar keratodermas.

The British journal of dermatology

Avec: R L Weinberg , P A Coulombe , M Polydefkis , M J Caterina

Correction to: Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis.

Journal of neurology

Avec: Alejandra González-Duarte , John L Berk , Dianna Quan , Michelle L Mauermann , Hartmut H Schmidt , Michael Polydefkis , Márcia Waddington-Cruz , Mitsuharu Ueda , Isabel M Conceição , Arnt V Kristen , Teresa Coelho , Cécile A Cauquil , Céline Tard , Madeline Merkel , Emre Aldinc , Jihong Chen , Marianne T Sweetser , Jing Jing Wang , David Adams

mNIS+7 and lower limb function in inotersen treatment of hereditary transthyretin-mediated amyloidosis.

Muscle & nerve

Avec: P James B Dyck , John C Kincaid , Janice F Wiesman , Michael Polydefkis , William J Litchy , Michelle L Mauermann , Elizabeth J Ackermann , Spencer Guthrie , Michael Pollock , Shiangtung W Jung , Brenda F Baker , Peter J Dyck

Large Mitochondrial DNA Deletions in HIV Sensory Neuropathy.

Neurology

Avec: Ricardo H Roda , David Bargiela , Weiran Chen , Ken Perry , Ronald J Ellis , David B Clifford , Ajay Bharti , Asha R Kallianpur , Michelli F Oliveira , Monica M Diaz , Leah H Rubin , Christina Gavegnano , Justin C McArthur , Ahmet Hoke , Michael Polydefkis

Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis.

Neurology

Avec: Simina Ticau , Gautham V Sridharan , Shira Tsour , William L Cantley , Amy Chan , Jason A Gilbert , David Erbe , Emre Aldinc , Mary M Reilly , David Adams , Michael Polydefkis , Kevin Fitzgerald , Akshay Vaishnaw , Paul Nioi

Hereditary transthyretin amyloid neuropathies: advances in pathophysiology, biomarkers, and treatment.

The Lancet. Neurology

Avec: David Adams , Yoshiki Sekijima , Isabel Conceição , Marcia Waddington-Cruz , Michael Polydefkis , Andoni Echaniz-Laguna , Mary M Reilly

Diagnosis and treatment of hereditary transthyretin amyloidosis with polyneuropathy in the United States: Recommendations from a panel of experts.

Muscle & nerve

Avec: Chafic Karam , Michelle L Mauermann , Alejandra Gonzalez-Duarte , Michelle C Kaku , Senda Ajroud-Driss , Thomas H Brannagan , Michael Polydefkis

TTR gene silencing therapy in post liver transplant hereditary ATTR amyloidosis patients.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Avec: Orly Moshe-Lilie , Diana Dimitrova , Stephen B Heitner , Thomas H Brannagan , Sasha Zivkovic , Mazen Hanna , Ahmad Masri , Michael Polydefkis , John L Berk , Morie A Gertz , Chafic Karam

Effect of diabetes type on long-term outcome of epidermal axon regeneration.

Annals of clinical and translational neurology

Avec: Mohammad Khoshnoodi , Shaun Truelove , Michael Polydefkis

Large Pleural Effusion: A Pitfall in the Quantitation of 99m Tc-PYP Imaging for ATTR Cardiac Amyloidosis.

Clinical nuclear medicine

Avec: Wajahat Khatri , Michael Polydefkis , Joban Vaishnav , Elie Saad , Lilja B Solnes , Steven P Rowe

Treatment response and neurofilament light chain levels with long-term patisiran in hereditary transthyretin-mediated amyloidosis with polyneuropathy: 24-month results of an open-label extension study.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Avec: Simina Ticau , Emre Aldinc , Michael Polydefkis , David Adams , Teresa Coelho , Mitsuharu Ueda , Cecilia Hale , John Vest , Paul Nioi , Auteur inconnu

Neurofilament Light Chains in Systemic Amyloidosis: A Systematic Review.

International journal of molecular sciences

Avec: Milou Berends , Hans L A Nienhuis , David Adams , Chafic Karam , Marco Luigetti , Michael Polydefkis , Mary M Reilly , Yoshiki Sekijima , Bouke P C Hazenberg

Race and Socioeconomic Status Impact Diagnosis and Clinical Outcomes in Transthyretin Cardiac Amyloidosis.

JACC. CardioOncology

Avec: Bairavi Shankar , Lisa Yanek , Artrish Jefferson , Vivek Jani , Emily Brown , Daniel Tsottles , Jennifer Barranco , Serena Zampino , Mark Ranek , Kavita Sharma , Michael Polydefkis , Joban Vaishnav

An indirect treatment comparison of the efficacy of patisiran and tafamidis for the treatment of hereditary transthyretin-mediated amyloidosis with polyneuropathy.

Expert opinion on pharmacotherapy

Avec: Violaine Planté-Bordeneuve , Hollis Lin , Jared Gollob , Sonalee Agarwal , Marissa Betts , Kyle Fahrbach , Madhura Chitnis , Michael Polydefkis

Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis.

Journal of neurology

Avec: Teresa Coelho , Aaron Yarlas , Marcia Waddington-Cruz , Michelle K White , Asia Sikora Kessler , Andrew Lovley , Michael Pollock , Spencer Guthrie , Elizabeth J Ackermann , Steven G Hughes , Chafic Karam , Sami Khella , Morie Gertz , Giampaolo Merlini , Laura Obici , Hartmut H Schmidt , Michael Polydefkis , P James B Dyck , Thomas H Brannagan Iii , Isabel Conceição , Merrill D Benson , John L Berk

Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study.

The Lancet. Neurology

Avec: David Adams , Michael Polydefkis , Alejandra González-Duarte , Jonas Wixner , Arnt V Kristen , Hartmut H Schmidt , John L Berk , Inés Asunción Losada López , Angela Dispenzieri , Dianna Quan , Isabel M Conceição , Michel S Slama , Julian D Gillmore , Theodoros Kyriakides , Senda Ajroud-Driss , Márcia Waddington-Cruz , Michelle M Mezei , Violaine Planté-Bordeneuve , Shahram Attarian , Elizabeth Mauricio , Thomas H Brannagan , Mitsuharu Ueda , Emre Aldinc , Jing Jing Wang , Matthew T White , John Vest , Erhan Berber , Marianne T Sweetser , Teresa Coelho , Auteur inconnu

Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression.

Orphanet journal of rare diseases

Avec: David Adams , Vincent Algalarrondo , Michael Polydefkis , Nitasha Sarswat , Michel S Slama , Jose Nativi-Nicolau

Mycobacterium leprae induces Schwann cell proliferation and migration in a denervated milieu following intracutaneous excision axotomy in nine-banded armadillos.

Experimental neurology

Avec: Gigi J Ebenezer , Maria T Pena , Amrita S Daniel , Richard W Truman , Linda Adams , Malcolm S Duthie , Kelly Wagner , Serena Zampino , Eleanor Tolf , Daniel Tsottles , Michael Polydefkis

Neuropathic symptoms with SARS-CoV-2 vaccination.

medRxiv : the preprint server for health sciences

Avec: Farinaz Safavi , Lindsey Gustafson , Brian Walitt , Tanya Lehky , Sara Dehbashi , Amanda Wiebold , Yair Mina , Susan Shin , Baohan Pan , Michael Polydefkis , Anne Louise Oaklander , Avindra Nath

Coexistence of Light Chain and Transthyretin Cardiac Amyloidosis.

JACC. Case reports

Avec: Abhishek Gami , John Woller , Paul Scheel , Syed Abbas Ali , Carol Ann Huff , Charles Steenbergen , Marc Halushka , Kavita Sharma , Michael Polydefkis , Joban Vaishnav

A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata.

Pharmacology research & perspectives

Avec: Samira Anderson , Guido Cavaletti , Linda J Hood , Michael Polydefkis , David N Herrmann , Gary Rance , Brett King , Amy J McMichael , Maryanne M Senna , Brian S Kim , Lynne Napatalung , Robert Wolk , Samuel H Zwillich , Gregor Schaefer , Yankun Gong , Melanie Sisson , Holly B Posner

A phase II, open-label, extension study of long-term patisiran treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis.

Orphanet journal of rare diseases

Avec: Teresa Coelho , David Adams , Isabel Conceição , Márcia Waddington-Cruz , Hartmut H Schmidt , Juan Buades , Josep Campistol , John L Berk , Michael Polydefkis , Jing Jing Wang , Jihong Chen , Marianne T Sweetser , Jared Gollob , Ole B Suhr

Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis.

Journal of neurology

Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7.

Journal of the neurological sciences

Avec: P James B Dyck , A González-Duarte , L Obici , M Polydefkis , J F Wiesman , I Antonino , W J Litchy , Peter J Dyck

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Avec: David Adams , Ivailo L Tournev , Mark S Taylor , Teresa Coelho , Violaine Planté-Bordeneuve , John L Berk , Alejandra González-Duarte , Julian D Gillmore , Soon-Chai Low , Yoshiki Sekijima , Laura Obici , Chongshu Chen , Prajakta Badri , Seth M Arum , John Vest , Michael Polydefkis , Auteur inconnu

Phenotypes Associated With the Val122Ile, Leu58His, and Late-Onset Val30Met Variants in Patients With Hereditary Transthyretin Amyloidosis.

Neurology

Avec: Serena Zampino , Farooq H Sheikh , Joban Vaishnav , Daniel Judge , Baohan Pan , Amrita Daniel , Emily Brown , Gigi Ebenezer , Michael Polydefkis

Joint Hypermobility, Autonomic Dysfunction, Gastrointestinal Dysfunction and Autoimmune markers (JAG-A): Clinical Associations and Response to Intravenous Immunoglobulin Therapy.

The American journal of gastroenterology

Avec: Pankaj J Pasricha , Megan McKnight , Luisa Villatoro , Guillermo Barahona , Jeffrey Brinker , Ken Hui , Michael Polydefkis , Robert Burns , Zsuzsanna H McMahan , Neda Gould , Brent Goodman , Joseph Hentz , Glenn Treisman

Symptoms of Hereditary Transthyretin Amyloidosis: The Patient and Physician Perspective.

Neurology and therapy

Avec: Michael Lane , Michael Polydefkis

Réseau de co-auteurs

David Adams 10 collaborations

John L Berk 7 collaborations

Teresa Coelho 7 collaborations

Hartmut H Schmidt 5 collaborations

Emre Aldinc 5 collaborations

Alejandra González-Duarte 4 collaborations

Michelle L Mauermann 4 collaborations

Márcia Waddington-Cruz 4 collaborations

Mitsuharu Ueda 4 collaborations

Marianne T Sweetser 4 collaborations

Jing Jing Wang 4 collaborations

Chafic Karam 4 collaborations

Joban Vaishnav 4 collaborations

Ahmet Hoke 3 collaborations

Dianna Quan 3 collaborations

Isabel M Conceição 3 collaborations

Arnt V Kristen 3 collaborations

Jihong Chen 3 collaborations

P James B Dyck 3 collaborations

Mary M Reilly 3 collaborations

Yoshiki Sekijima 3 collaborations

Isabel Conceição 3 collaborations

Thomas H Brannagan 3 collaborations

John Vest 3 collaborations

None None 3 collaborations

Serena Zampino 3 collaborations

Violaine Planté-Bordeneuve 3 collaborations

David N Herrmann 2 collaborations

Anne Louise Oaklander 2 collaborations

M Polydefkis 2 collaborations

Cécile A Cauquil 2 collaborations

Céline Tard 2 collaborations

Madeline Merkel 2 collaborations

Elizabeth J Ackermann 2 collaborations

Spencer Guthrie 2 collaborations

Michael Pollock 2 collaborations

Peter J Dyck 2 collaborations

Simina Ticau 2 collaborations

Paul Nioi 2 collaborations

Marcia Waddington-Cruz 2 collaborations

Senda Ajroud-Driss 2 collaborations

Emily Brown 2 collaborations

Daniel Tsottles 2 collaborations

Kavita Sharma 2 collaborations

Jared Gollob 2 collaborations

Laura Obici 2 collaborations

Michel S Slama 2 collaborations

Julian D Gillmore 2 collaborations

Baohan Pan 2 collaborations

Ying Liu 1 collaboration

Yuan Sun 1 collaboration

Osefame Ewaleifoh 1 collaboration

Josh Wei 1 collaboration

Ruifa Mi 1 collaboration

Jing Zhu 1 collaboration

Roy Freeman 1 collaboration

Jennifer S Gewandter 1 collaboration

Catharina G Faber 1 collaboration

Christopher Gibbons 1 collaboration

Simon Haroutounian 1 collaboration

Giuseppe Lauria 1 collaboration

Todd Levine 1 collaboration

Rayaz A Malik 1 collaboration

J Robinson Singleton 1 collaboration

A Gordon Smith 1 collaboration

Josh Bell 1 collaboration

Robert H Dworkin 1 collaboration

Eva Feldman 1 collaboration

Noah Kolb 1 collaboration

Heikki Mansikka 1 collaboration

Amanda Peltier 1 collaboration

Elissa Ritt 1 collaboration

James W Russell 1 collaboration

Stephen Sainati 1 collaboration

Deborah Steiner 1 collaboration

Roi Treister 1 collaboration

Nurcan Üçeyler 1 collaboration

R L Weinberg 1 collaboration

P A Coulombe 1 collaboration

M J Caterina 1 collaboration

John C Kincaid 1 collaboration

Janice F Wiesman 1 collaboration

William J Litchy 1 collaboration

Shiangtung W Jung 1 collaboration

Brenda F Baker 1 collaboration

Ricardo H Roda 1 collaboration

David Bargiela 1 collaboration

Weiran Chen 1 collaboration

Ken Perry 1 collaboration

Ronald J Ellis 1 collaboration

David B Clifford 1 collaboration

Ajay Bharti 1 collaboration

Asha R Kallianpur 1 collaboration

Michelli F Oliveira 1 collaboration

Monica M Diaz 1 collaboration

Leah H Rubin 1 collaboration

Christina Gavegnano 1 collaboration

Justin C McArthur 1 collaboration

Gautham V Sridharan 1 collaboration

Shira Tsour 1 collaboration

William L Cantley 1 collaboration

Amy Chan 1 collaboration

Jason A Gilbert 1 collaboration

David Erbe 1 collaboration

Kevin Fitzgerald 1 collaboration

Akshay Vaishnaw 1 collaboration

Andoni Echaniz-Laguna 1 collaboration

Alejandra Gonzalez-Duarte 1 collaboration

Michelle C Kaku 1 collaboration

Orly Moshe-Lilie 1 collaboration

Diana Dimitrova 1 collaboration

Stephen B Heitner 1 collaboration

Sasha Zivkovic 1 collaboration

Mazen Hanna 1 collaboration

Ahmad Masri 1 collaboration

Morie A Gertz 1 collaboration

Mohammad Khoshnoodi 1 collaboration

Shaun Truelove 1 collaboration

Wajahat Khatri 1 collaboration

Elie Saad 1 collaboration

Lilja B Solnes 1 collaboration

Steven P Rowe 1 collaboration

Cecilia Hale 1 collaboration

Milou Berends 1 collaboration

Hans L A Nienhuis 1 collaboration

Marco Luigetti 1 collaboration

Bouke P C Hazenberg 1 collaboration

Bairavi Shankar 1 collaboration

Lisa Yanek 1 collaboration

Artrish Jefferson 1 collaboration

Vivek Jani 1 collaboration

Jennifer Barranco 1 collaboration

Mark Ranek 1 collaboration

Hollis Lin 1 collaboration

Sonalee Agarwal 1 collaboration

Marissa Betts 1 collaboration

Kyle Fahrbach 1 collaboration

Madhura Chitnis 1 collaboration

Aaron Yarlas 1 collaboration

Michelle K White 1 collaboration

Asia Sikora Kessler 1 collaboration

Andrew Lovley 1 collaboration

Steven G Hughes 1 collaboration

Sami Khella 1 collaboration

Morie Gertz 1 collaboration

Giampaolo Merlini 1 collaboration

Thomas H Brannagan Iii 1 collaboration

Merrill D Benson 1 collaboration

Jonas Wixner 1 collaboration

Inés Asunción Losada López 1 collaboration

Angela Dispenzieri 1 collaboration

Theodoros Kyriakides 1 collaboration

Michelle M Mezei 1 collaboration

Shahram Attarian 1 collaboration

Elizabeth Mauricio 1 collaboration

Matthew T White 1 collaboration

Erhan Berber 1 collaboration

Vincent Algalarrondo 1 collaboration

Nitasha Sarswat 1 collaboration

Jose Nativi-Nicolau 1 collaboration

Gigi J Ebenezer 1 collaboration

Maria T Pena 1 collaboration

Amrita S Daniel 1 collaboration

Richard W Truman 1 collaboration

Linda Adams 1 collaboration

Malcolm S Duthie 1 collaboration

Kelly Wagner 1 collaboration

Eleanor Tolf 1 collaboration

Farinaz Safavi 1 collaboration

Lindsey Gustafson 1 collaboration

Brian Walitt 1 collaboration

Tanya Lehky 1 collaboration

Sara Dehbashi 1 collaboration

Amanda Wiebold 1 collaboration

Yair Mina 1 collaboration

Susan Shin 1 collaboration

Avindra Nath 1 collaboration

Abhishek Gami 1 collaboration

John Woller 1 collaboration

Paul Scheel 1 collaboration

Syed Abbas Ali 1 collaboration

Carol Ann Huff 1 collaboration

Charles Steenbergen 1 collaboration

Marc Halushka 1 collaboration

Samira Anderson 1 collaboration

Guido Cavaletti 1 collaboration

Linda J Hood 1 collaboration

Gary Rance 1 collaboration

Brett King 1 collaboration

Amy J McMichael 1 collaboration

Maryanne M Senna 1 collaboration

Brian S Kim 1 collaboration

Lynne Napatalung 1 collaboration

Robert Wolk 1 collaboration

Samuel H Zwillich 1 collaboration

Gregor Schaefer 1 collaboration

Yankun Gong 1 collaboration

Melanie Sisson 1 collaboration

Holly B Posner 1 collaboration

Juan Buades 1 collaboration

Josep Campistol 1 collaboration

Ole B Suhr 1 collaboration

A González-Duarte 1 collaboration

L Obici 1 collaboration

J F Wiesman 1 collaboration

I Antonino 1 collaboration

W J Litchy 1 collaboration

Ivailo L Tournev 1 collaboration

Mark S Taylor 1 collaboration

Soon-Chai Low 1 collaboration

Chongshu Chen 1 collaboration

Prajakta Badri 1 collaboration

Seth M Arum 1 collaboration

Farooq H Sheikh 1 collaboration

Daniel Judge 1 collaboration

Amrita Daniel 1 collaboration

Gigi Ebenezer 1 collaboration

Pankaj J Pasricha 1 collaboration

Megan McKnight 1 collaboration

Luisa Villatoro 1 collaboration

Guillermo Barahona 1 collaboration

Jeffrey Brinker 1 collaboration

Ken Hui 1 collaboration

Robert Burns 1 collaboration

Zsuzsanna H McMahan 1 collaboration

Neda Gould 1 collaboration

Brent Goodman 1 collaboration

Joseph Hentz 1 collaboration

Glenn Treisman 1 collaboration

Michael Lane 1 collaboration