Rimegepant orally disintegrating tablet 75 mg for acute treatment of migraine in adults from China: a subgroup analysis of a double-blind, randomized, placebo-controlled, phase 3 clinical trial.

Acute treatment China Clinical trial Migraine Rimegepant

Journal

The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562

Informations de publication

Date de publication:
16 Apr 2024
Historique:
received: 12 12 2023
accepted: 11 02 2024
medline: 17 4 2024
pubmed: 17 4 2024
entrez: 16 4 2024
Statut: epublish

Résumé

Rimegepant orally disintegrating tablet (ODT), an oral small-molecule calcitonin gene-related peptide receptor antagonist, is indicated for acute and preventive treatment of migraine in the United States and other countries. Previously, a large clinical trial assessed the efficacy and safety of rimegepant ODT 75 mg for the acute treatment of migraine in adults living in China or South Korea. A post hoc subgroup analysis of this trial was performed to evaluate the efficacy and safety of rimegepant for acute treatment of migraine in adults living in China. Eligible participants were ≥ 18 years of age and had a ≥ 1-year history of migraine, with 2 to 8 attacks of moderate or severe pain intensity per month and < 15 headache days per month during the 3 months before screening. Participants self-administered rimegepant ODT 75 mg or matching placebo to treat a single migraine attack of moderate or severe pain intensity. The co-primary endpoints were pain freedom and freedom from the most bothersome symptom (MBS) at 2 h post-dose. Key secondary endpoints included pain relief at 2 h post-dose, ability to function normally at 2 h post-dose, use of rescue medication within 24 h post-dose, and sustained pain freedom from 2 to 24 h and 2 to 48 h post-dose. All p values were nominal. Safety was assessed via treatment-emergent adverse events (TEAEs), electrocardiograms, vital signs, and routine laboratory tests. Overall, 1075 participants (rimegepant, n = 538; placebo, n = 537) were included in the subgroup analysis. Rimegepant was more effective than placebo for the co-primary endpoints of pain freedom (18.2% vs. 10.6%, p = 0.0004) and freedom from the MBS (48.0% vs. 31.8%, p <  0.0001), as well as all key secondary endpoints. The incidence of TEAEs was comparable between the rimegepant (15.2%) and placebo (16.4%) groups. No signal of drug-induced liver injury was observed, and no study drug-related serious TEAEs were reported in the rimegepant group. A single dose of rimegepant 75 mg rimegepant was effective for the acute treatment of migraine in adults living in China, with safety and tolerability similar to placebo. Clinicaltrials.gov NCT04574362 Date registered: 2020-10-05.

Sections du résumé

BACKGROUND BACKGROUND
Rimegepant orally disintegrating tablet (ODT), an oral small-molecule calcitonin gene-related peptide receptor antagonist, is indicated for acute and preventive treatment of migraine in the United States and other countries. Previously, a large clinical trial assessed the efficacy and safety of rimegepant ODT 75 mg for the acute treatment of migraine in adults living in China or South Korea. A post hoc subgroup analysis of this trial was performed to evaluate the efficacy and safety of rimegepant for acute treatment of migraine in adults living in China.
METHODS METHODS
Eligible participants were ≥ 18 years of age and had a ≥ 1-year history of migraine, with 2 to 8 attacks of moderate or severe pain intensity per month and < 15 headache days per month during the 3 months before screening. Participants self-administered rimegepant ODT 75 mg or matching placebo to treat a single migraine attack of moderate or severe pain intensity. The co-primary endpoints were pain freedom and freedom from the most bothersome symptom (MBS) at 2 h post-dose. Key secondary endpoints included pain relief at 2 h post-dose, ability to function normally at 2 h post-dose, use of rescue medication within 24 h post-dose, and sustained pain freedom from 2 to 24 h and 2 to 48 h post-dose. All p values were nominal. Safety was assessed via treatment-emergent adverse events (TEAEs), electrocardiograms, vital signs, and routine laboratory tests.
RESULTS RESULTS
Overall, 1075 participants (rimegepant, n = 538; placebo, n = 537) were included in the subgroup analysis. Rimegepant was more effective than placebo for the co-primary endpoints of pain freedom (18.2% vs. 10.6%, p = 0.0004) and freedom from the MBS (48.0% vs. 31.8%, p <  0.0001), as well as all key secondary endpoints. The incidence of TEAEs was comparable between the rimegepant (15.2%) and placebo (16.4%) groups. No signal of drug-induced liver injury was observed, and no study drug-related serious TEAEs were reported in the rimegepant group.
CONCLUSIONS CONCLUSIONS
A single dose of rimegepant 75 mg rimegepant was effective for the acute treatment of migraine in adults living in China, with safety and tolerability similar to placebo.
TRIAL REGISTRATION BACKGROUND
Clinicaltrials.gov NCT04574362 Date registered: 2020-10-05.

Identifiants

pubmed: 38627638
doi: 10.1186/s10194-024-01731-4
pii: 10.1186/s10194-024-01731-4
doi:

Banques de données

ClinicalTrials.gov
['NCT04574362']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

57

Informations de copyright

© 2024. The Author(s) and Pfizer.

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Auteurs

Shengyuan Yu (S)

Chinese PLA General Hospital, Beijing, China.

Aihong Guo (A)

Xianyang Hospital, Yan'an University, Xianyang, China.

Zhen Wang (Z)

Changsha Central Hospital, Changsha, China.

Jianguang Liu (J)

Wuhan Third Hospital, Wuhan, China.

Ge Tan (G)

The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Qian Yang (Q)

Shaanxi Provincial Hospital, Xi'an, China.

Mingjie Zhang (M)

Chinese PLA General Hospital, Beijing, China.

Hasiyeti Yibulaiyin (H)

The Second Affiliated Hospital of Xinjiang Medical University, Wulumuqi, Xinjiang Province, China.

Huisheng Chen (H)

General Hospital of Northern Theater Command, District, Shenyang, Liaoning Province, China.

Yongbo Zhang (Y)

Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Robert Croop (R)

Biohaven Pharmaceuticals, New Haven, CT, USA.

Yanhui Sun (Y)

Pfizer (China) Research and Development Co., Ltd, Shanghai, China.

Yu Liu (Y)

Pfizer Inc, Beijing, China.

Qian Zhao (Q)

Pfizer Inc, Chengdu, China.

Zhihong Lu (Z)

Pfizer (China) Research and Development Co., Ltd, Shanghai, China. luzhihong57@outlook.com.

Classifications MeSH