Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA).
aging
autophagy
gene expression
mTor
mitochondria
mobility
oxidative metabolism
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
16 Apr 2024
16 Apr 2024
Historique:
revised:
14
01
2024
received:
04
11
2023
accepted:
02
02
2024
medline:
17
4
2024
pubmed:
17
4
2024
entrez:
17
4
2024
Statut:
aheadofprint
Résumé
Autophagy is essential for proteostasis, energetic balance, and cell defense and is a key pathway in aging. Identifying associations between autophagy gene expression patterns in skeletal muscle and physical performance outcomes would further our knowledge of mechanisms related with proteostasis and healthy aging. Muscle biopsies were obtained from participants in the Study of Muscle, Mobility, and Aging (SOMMA). For 575 participants, RNA was sequenced and expression of 281 genes related to autophagy regulation, mitophagy, and mTOR/upstream pathways was determined. Associations between gene expression and outcomes including mitochondrial respiration in muscle fiber bundles (MAX OXPHOS), physical performance (VO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14118Subventions
Organisme : NIA NIH HHS
ID : R01AG059416
Pays : United States
Informations de copyright
© 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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