Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
19 Apr 2024
Historique:
medline: 19 4 2024
pubmed: 19 4 2024
entrez: 19 4 2024
Statut: ppublish

Résumé

Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7

Identifiants

DOI: 10.1126/sciimmunol.adg7549 PMID: 38640252
pubmed: 38640252
doi: 10.1126/sciimmunol.adg7549
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadg7549

Auteurs

Pablo Canales-Herrerias (P)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-1865-6476

Mathieu Uzzan (M)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Paris Est Créteil University UPEC, Assistance Publique-Hôpitaux de Paris (AP-HP), Henri Mondor Hospital, Gastroenterology Department, Fédération Hospitalo-Universitaire TRUE (InnovaTive theRapy for immUne disordErs), Créteil F-94010, France.
ORCID: 0000-0002-7761-2879

Akihiro Seki (A)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-0356-1810

Rafael S Czepielewski (RS)

Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-2475-3838

Bram Verstockt (B)

Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
ORCID: 0000-0003-3898-7093

Alexandra E Livanos (AE)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8418-3400

Fiona Raso (F)

Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
ORCID: 0000-0001-9677-5801

Alexandra Dunn (A)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Daniel Dai (D)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-2522-6084

Andrew Wang (A)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-8018-3828

Zainab Al-Taie (Z)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-2624-2035

Jerome Martin (J)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nantes Université, CHU Nantes, Inserm, Centre de Recherche Translationelle en Transplantation et Immunologie, UMR 1064, Nantes, France.
CHU Nantes, Nantes Université, Laboratoire d'Immunologie, CIMNA, Nantes, France.

Thomas Laurent (T)

Nantes Université, CHU Nantes, Inserm, Centre de Recherche Translationelle en Transplantation et Immunologie, UMR 1064, Nantes, France.
CHU Nantes, Nantes Université, Laboratoire d'Immunologie, CIMNA, Nantes, France.

Huaibin M Ko (HM)

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-1062-2383

Minami Tokuyama (M)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-6488-9687

Michael Tankelevich (M)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Hadar Meringer (H)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-2624-2505

Francesca Cossarini (F)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8793-5241

Divya Jha (D)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-5038-241X

Azra Krek (A)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0009-0001-7845-9984

John D Paulsen (JD)

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-6525-9126

Matthew D Taylor (MD)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Mohammad Zuber Nakadar (MZ)

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0009-0002-2946-0978

Joshua Wong (J)

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Emma C Erlich (EC)

Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0003-2584-1407

Rachel L Mintz (RL)

Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA.

Emily J Onufer (EJ)

Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-8802-5346

Beth A Helmink (BA)

Department of Surgery, Section of Surgical Oncology, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-8206-0351

Keshav Sharma (K)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Adam Rosenstein (A)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Danielle Ganjian (D)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Grace Chung (G)

Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-7101-6865

Travis Dawson (T)

Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-9609-793X

Julius Juarez (J)

Takeda Pharmaceuticals, Cambridge, MA, USA.

Vijay Yajnik (V)

Takeda Pharmaceuticals, Cambridge, MA, USA.
ORCID: 0000-0001-6767-1712

Andrea Cerutti (A)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain.
ORCID: 0000-0003-3026-4704

Jeremiah J Faith (JJ)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-2691-4500

Mayte Suarez-Farinas (M)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Carmen Argmann (C)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Francesca Petralia (F)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Gwendalyn J Randolph (GJ)

Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0001-9045-1195

Alexandros D Polydorides (AD)

Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-8604-0756

Andrea Reboldi (A)

Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
ORCID: 0000-0003-1137-6292

Jean-Frederic Colombel (JF)

Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-6472-249X

Saurabh Mehandru (S)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-9781-2969

Classifications MeSH