Effects of taxane-induced peripheral neuropathy on hand dexterity impairment: evaluation of quantitative and subjective assessments.
Humans
Female
Middle Aged
Peripheral Nervous System Diseases
/ chemically induced
Hand Strength
/ physiology
Taxoids
/ adverse effects
Aged
Adult
Hand
/ physiopathology
Breast Neoplasms
/ drug therapy
Surveys and Questionnaires
Antineoplastic Agents
/ adverse effects
Regression Analysis
Disability Evaluation
Bridged-Ring Compounds
/ adverse effects
Cancer survivors
Grip force control
Hand dexterity
Quantitative sensory testing
Taxane-induced peripheral neuropathy
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
23 Apr 2024
23 Apr 2024
Historique:
received:
12
09
2023
accepted:
14
04
2024
medline:
23
4
2024
pubmed:
23
4
2024
entrez:
23
4
2024
Statut:
epublish
Résumé
Chemotherapy-induced peripheral neuropathy (CIPN) commonly involves hand dexterity impairment. However, the factors affecting hand dexterity impairment are unknown and there is currently no established treatment. The purpose of the current study was to clarify factors influencing hand dexterity impairment in taxane-induced peripheral neuropathy using subjective and objective assessments. We assessed patient characteristics, treatment-related factors, subjective symptoms of CIPN (Patient Neurotoxicity Questionnaire [PNQ]), psychological symptoms, and upper limb dysfunction (Quick Disabilities of the Arm, Shoulder and Hand [Quick DASH]). Quantitative assessments were pinch strength, sensory threshold, hand dexterity impairment, and grip force control. Multiple regression analysis was performed using hand dexterity impairment as the dependent variable and age and PNQ, Quick DASH, and control of grip force as independent variables. Forty-three breast cancer patients were included in the analysis. Hand dexterity impairment in taxane-induced peripheral neuropathy patients was significantly correlated with age, grip force control, and PNQ sensory scores (p < 0.008). Multiple regression analysis demonstrated that PNQ sensory scores and grip force control were significantly associated with hand dexterity impairment (p < 0.01). Subjective symptoms (numbness and pain) and grip force control contributed to impaired hand dexterity in taxane-induced peripheral neuropathy.
Identifiants
pubmed: 38652168
doi: 10.1007/s00520-024-08504-4
pii: 10.1007/s00520-024-08504-4
doi:
Substances chimiques
Taxoids
0
Antineoplastic Agents
0
taxane
1605-68-1
Bridged-Ring Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
304Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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