Identification of the potassium-binding site in serotonin transporter.
antiport
molecular dynamics simulations
patch clamp electrophysiology
proteoliposomes
transporter
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
30 Apr 2024
30 Apr 2024
Historique:
medline:
23
4
2024
pubmed:
23
4
2024
entrez:
23
4
2024
Statut:
ppublish
Résumé
Clearance of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter (SERT), which couples this process to the movement of a Na
Identifiants
pubmed: 38652746
doi: 10.1073/pnas.2319384121
doi:
Substances chimiques
Serotonin Plasma Membrane Transport Proteins
0
Potassium
RWP5GA015D
Sodium
9NEZ333N27
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2319384121Subventions
Organisme : HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : NS003139
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 32071233
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 32371304
Organisme : Guangzhou City-University Joint Research Program
ID : 2023A03J0046
Organisme : Basic and Innovative Research Program for Guangzhou University Postgraduate Students
ID : 2022GDJC-M15
Organisme : Austrian Science Fund (FWF)
ID : P36667
Organisme : Vienna Science and Technology Fund (WWTF)
ID : LSC17-026
Organisme : HHS | National Institutes of Health (NIH)
ID : R01NS102277
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.