Comparative Study of Paraneoplastic and Nonparaneoplastic Autoimmune Encephalitis With GABA
Journal
Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
medline:
24
4
2024
pubmed:
24
4
2024
entrez:
24
4
2024
Statut:
ppublish
Résumé
While patients with paraneoplastic autoimmune encephalitis (AE) with gamma-aminobutyric-acid B receptor antibodies (GABA Patients with GABA A total of 111 patients (44/111 [40%] women) were enrolled, including 84 of 111 (76%) paraneoplastic and 18 of 111 (16%) nonparaneoplastic cases (cancer status was undetermined for 9 patients). Patients presented with seizures (88/111 [79%]), cognitive impairment (54/111 [49%]), and/or behavioral disorders (34/111 [31%]), and 54 of 111 (50%) were admitted in intensive care unit (ICU). Nonparaneoplastic patients were significantly younger (median age 54 years [range 19-88] vs 67 years [range 50-85] for paraneoplastic cases, Nonparaneoplastic GABA
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
While patients with paraneoplastic autoimmune encephalitis (AE) with gamma-aminobutyric-acid B receptor antibodies (GABA
METHODS
METHODS
Patients with GABA
RESULTS
RESULTS
A total of 111 patients (44/111 [40%] women) were enrolled, including 84 of 111 (76%) paraneoplastic and 18 of 111 (16%) nonparaneoplastic cases (cancer status was undetermined for 9 patients). Patients presented with seizures (88/111 [79%]), cognitive impairment (54/111 [49%]), and/or behavioral disorders (34/111 [31%]), and 54 of 111 (50%) were admitted in intensive care unit (ICU). Nonparaneoplastic patients were significantly younger (median age 54 years [range 19-88] vs 67 years [range 50-85] for paraneoplastic cases,
DISCUSSION
CONCLUSIONS
Nonparaneoplastic GABA
Identifiants
pubmed: 38657198
doi: 10.1212/NXI.0000000000200229
doi:
Substances chimiques
Receptors, GABA-B
0
Autoantibodies
0
Types de publication
Journal Article
Comparative Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM