The clinical relevance of different antiphospholipid antibody profiles in pediatric rheumatology patients.
Humans
Female
Male
Child
Retrospective Studies
Antibodies, Antiphospholipid
/ blood
Adolescent
beta 2-Glycoprotein I
/ immunology
Antibodies, Anticardiolipin
/ blood
Antiphospholipid Syndrome
/ immunology
Child, Preschool
Lupus Coagulation Inhibitor
/ blood
Rheumatic Diseases
/ immunology
Thrombosis
/ etiology
Clinical Relevance
Antiphospholipid syndrome
Pediatrics
Rheumatology
Thrombosis
Journal
Pediatric rheumatology online journal
ISSN: 1546-0096
Titre abrégé: Pediatr Rheumatol Online J
Pays: England
ID NLM: 101248897
Informations de publication
Date de publication:
26 Apr 2024
26 Apr 2024
Historique:
received:
24
10
2023
accepted:
29
12
2023
medline:
27
4
2024
pubmed:
27
4
2024
entrez:
26
4
2024
Statut:
epublish
Résumé
The clinical relevance of different antiphospholipid antibody (aPL) profiles, including low level anticardiolipin (aCL) and anti-β In this single center retrospective cohort study, based on the screening of our pediatric (age ≤ 18) rheumatology electronic medical records (2016-2022), we identified patients who had at least one "positive" aPL (lupus anticoagulant [LA], aCL IgG/M, or aβ An initial high-risk aPL profile was persistent in approximately 90% of our cohort, a third of whom had thrombosis, and half had non-thrombotic aPL manifestations. Our results underscore the need for a large-scale effort to better characterize aPL-related manifestations in pediatric patients with persistent high-risk aPL-profiles.
Sections du résumé
BACKGROUND
BACKGROUND
The clinical relevance of different antiphospholipid antibody (aPL) profiles, including low level anticardiolipin (aCL) and anti-β
FINDINGS
RESULTS
In this single center retrospective cohort study, based on the screening of our pediatric (age ≤ 18) rheumatology electronic medical records (2016-2022), we identified patients who had at least one "positive" aPL (lupus anticoagulant [LA], aCL IgG/M, or aβ
CONCLUSION
CONCLUSIONS
An initial high-risk aPL profile was persistent in approximately 90% of our cohort, a third of whom had thrombosis, and half had non-thrombotic aPL manifestations. Our results underscore the need for a large-scale effort to better characterize aPL-related manifestations in pediatric patients with persistent high-risk aPL-profiles.
Identifiants
pubmed: 38671480
doi: 10.1186/s12969-024-00954-8
pii: 10.1186/s12969-024-00954-8
doi:
Substances chimiques
Antibodies, Antiphospholipid
0
beta 2-Glycoprotein I
0
Antibodies, Anticardiolipin
0
Lupus Coagulation Inhibitor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
46Informations de copyright
© 2024. The Author(s).
Références
Avčin T. Antiphospholipid syndrome in children. Curr Opin Rheumatol. 2008;20(5):595–600. https://doi.org/10.1097/BOR.0B013E3283060A8C .
doi: 10.1097/BOR.0B013E3283060A8C
pubmed: 18698184
Garcia D, Erkan D. Diagnosis and management of the Antiphospholipid Syndrome. N Engl J Med. 2018;378(21):2010–21. https://doi.org/10.1056/nejmra1705454 .
doi: 10.1056/nejmra1705454
pubmed: 29791828
Avčin T, Cimaz R, Silverman ED, et al. Pediatric antiphospholipid syndrome: clinical and immunologic features of 121 patients in an international registry. Pediatrics. 2008;122(5). https://doi.org/10.1542/peds.2008-1209 .
Soybilgic A, Avcin T, Pediatric APS. State of the Art. Published online 2020. https://doi.org/10.1007/s11926-020-0887-9 .
Sevim E, Zisa D, Andrade D, et al. Characteristics of patients with antiphospholipid antibody positivity in the APS ACTION International Clinical Database and Repository. Arthritis Care Res (Hoboken). 2022;74(2):324–35. https://doi.org/10.1002/acr.24468 .
doi: 10.1002/acr.24468
pubmed: 32986935
Barbhaiya M, Taghavi M, Zuily S et al. Efforts to Better Characterize Antiphospholipid Antibody Nephropathy for the 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria: Renal Pathology Subcommittee Report. J Rheumatol. Published online September 1, 2023:jrheum.2022– 1200. https://doi.org/10.3899/JRHEUM.2022-1200 .
Barbhaiya M, Zuily S, Naden R et al. 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria. Arthritis and Rheumatology. Published online 2023. https://doi.org/10.1002/art.42624 .
Pengo V, Biasiolo A, Pegoraro C, Cucchini U, Noventa F, Iliceto S. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb Haemost. 2005;93(6):1147–52. https://doi.org/10.1160/TH04-12-0839/ID/JR0839-1/BIB .
doi: 10.1160/TH04-12-0839/ID/JR0839-1/BIB
pubmed: 15968401
Zuily S, de Laat B, Mohamed S, et al. Validity of the global anti-phospholipid syndrome score to predict thrombosis: a prospective multicentre cohort study. Rheumatology (Oxford). 2015;54(11):2071–5. https://doi.org/10.1093/RHEUMATOLOGY/KEV238 .
doi: 10.1093/RHEUMATOLOGY/KEV238
pubmed: 26163690
Rozic M, Trampus-Bakija A, Rener-Primec Z, Kitanovski L, Kveder T, Avcin T. PReS-FINAL-2349: Spectrum of thrombotic and non-thrombotic manifestations in 159 children with positive antiphospholipid antibodies. Pediatric Rheumatology 2013 11:2. 2013;11(2):1–2. https://doi.org/10.1186/1546-0096-11-S2-P339 .
Avčin T, Cimaz R, Rozman B, et al. The Ped-APS registry: the antiphospholipid syndrome in childhood. Lupus. 2009;18(10):894–9. https://doi.org/10.1177/0961203309106917 .
doi: 10.1177/0961203309106917
pubmed: 19671789
Aguiar CL, Soybilgic A, Avcin T, Myones BL. Pediatric Antiphospholipid Syndrome. Published online 2015. https://doi.org/10.1007/s11926-015-0504-5 .
Cervera R, Piette JC, Font J, et al. Antiphospholipid Syndrome Clinical and immunologic manifestations and patterns of Disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002;46(4):1019–27. https://doi.org/10.1002/art.10187 .
doi: 10.1002/art.10187
pubmed: 11953980
Rumsey DG, Myones B, Massicotte P. Diagnosis and treatment of antiphospholipid syndrome in childhood: a review. Blood Cells Mol Dis. 2017;67:34–40. https://doi.org/10.1016/J.BCMD.2017.02.009 .
doi: 10.1016/J.BCMD.2017.02.009
pubmed: 28283251
Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295–306. https://doi.org/10.1111/J.1538-7836.2006.01753.X .
doi: 10.1111/J.1538-7836.2006.01753.X
pubmed: 16420554
Wincup C, Ioannou Y. The differences between childhood and adult onset antiphospholipid syndrome. Front Pediatr. 2018;6(November):1–10. https://doi.org/10.3389/fped.2018.00362 .
doi: 10.3389/fped.2018.00362