pH-Sensitive Amphiphilic Diblock Polyphosphoesters with Lactate Units: Synthesis and Application as Drug Carriers.

Hydrogen-Ion Concentration Drug Carriers / chemistry Doxorubicin / chemistry Micelles Lactic Acid / chemistry Polymers / chemistry Humans Esters / chemistry Hydrophobic and Hydrophilic Interactions Molecular Weight
amphiphilic polymers drug delivery micelles polyphosphoesters

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
20 Apr 2024
Historique:
received: 13 03 2024
revised: 09 04 2024
accepted: 19 04 2024
medline: 27 4 2024
pubmed: 27 4 2024
entrez: 27 4 2024
Statut: epublish

Résumé

pH-sensitive amphiphilic diblock polyphosphoesters containing lactic acid units were synthesized by multistep one-pot polycondensation reactions. They comprise acid-labile P(O)-O-C and C(O)-O-C bonds, the cleavage of which depends on the pH of the medium. The structure of these copolymers was characterized by

Identifiants

DOI: 10.3390/ijms25084518 PMID: 38674103
pubmed: 38674103
pii: ijms25084518
doi: 10.3390/ijms25084518
pii:
doi:

Substances chimiques

Drug Carriers 0
Doxorubicin 80168379AG
Micelles 0
Lactic Acid 33X04XA5AT
Polymers 0
Esters 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : S1001019

Auteurs

Kasumi Mochizuki (K)

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda 278-8510, Chiba, Japan.

Violeta Mitova (V)

Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
ORCID: 0000-0002-2714-7980

Kimiko Makino (K)

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda 278-8510, Chiba, Japan.

Hiroshi Terada (H)

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda 278-8510, Chiba, Japan.

Issei Takeuchi (I)

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda 278-8510, Chiba, Japan.
Faculty of Pharmaceutical Science, Josai International University, 1 Gumyo, Togane 283-8555, Chiba, Japan.
ORCID: 0000-0002-0611-7387

Kolio Troev (K)

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda 278-8510, Chiba, Japan.
Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
ORCID: 0000-0003-4158-8405

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Préparations pharmaceutiques › Micelles › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › pH-Sensitive Amphiphilic Diblock...
questionsmedicales.fr › Phénomènes chimiques › Masse moléculaire › pH-Sensitive Amphiphilic Diblock...