Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8.
Humans
Histones
/ metabolism
Apoptosis
/ drug effects
Acetylation
/ drug effects
Hydrogen Peroxide
/ pharmacology
Artemisinins
/ pharmacology
Retinal Pigment Epithelium
/ drug effects
Lysine
/ metabolism
Cell Survival
/ drug effects
Oxidative Stress
/ drug effects
Cell Line
Cytoprotection
/ drug effects
Epithelial Cells
/ drug effects
Acetyl-H4 (Lys 8)
Artemisinin
H2O2
apoptosis
cytoprotection
retinal pigment epithelial cells
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
15 Apr 2024
15 Apr 2024
Historique:
received:
26
02
2024
revised:
28
03
2024
accepted:
31
03
2024
medline:
27
4
2024
pubmed:
27
4
2024
entrez:
27
4
2024
Statut:
epublish
Résumé
Increased oxidative stress is one of the critical pathologies inducing age-related macular degeneration (AMD), characterized by retinal pigment epithelial (RPE) cell damage and death. The unbalanced acetylation and deacetylation of histones have been implicated in AMD pathogenesis or hydrogen peroxide (H
Identifiants
pubmed: 38675608
pii: molecules29081789
doi: 10.3390/molecules29081789
pii:
doi:
Substances chimiques
Histones
0
Hydrogen Peroxide
BBX060AN9V
Artemisinins
0
Lysine
K3Z4F929H6
artemisinin
9RMU91N5K2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31771128 and 31371088
Organisme : Science and Technology Development Fund
ID : 0127/2019/A3, 0113/2018/A3, 0038/2020/AMJ, and 0104/2022/A2
Organisme : Guangdong Provincial Funding Committee for Basic and Applied Fundamental Research
ID : 2022-Natural Science Foundation
Organisme : University of Macau
ID : MYRG2018-00134-FHS and MYRG2020-00158-FHS