Aldehyde Dehydrogenese-1 High Cancer Stem-like Cells/Cancer-initiating Cells Escape from Cytotoxic T Lymphocytes due to Lower Expression of Human Leukocyte Antigen Class 1.

Humans Neoplastic Stem Cells / metabolism Stomach Neoplasms / immunology Aldehyde Dehydrogenase 1 Family / metabolism Cell Line, Tumor T-Lymphocytes, Cytotoxic / immunology Retinal Dehydrogenase / metabolism Tumor Escape / immunology Histocompatibility Antigens Class I / metabolism
ALDH1 Gastric cancer HLA class 1 cancer stem cell cytotoxic T lymphocytes

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
May 2024
Historique:
received: 21 02 2024
revised: 11 03 2024
accepted: 12 03 2024
medline: 28 4 2024
pubmed: 28 4 2024
entrez: 27 4 2024
Statut: ppublish

Résumé

Human gastric cancer stem-like cells (CSCs)/cancer-initiating cells can be identified as aldehyde dehydrogenase-high (ALDH Gastric CSCs/CICs were isolated as ALDH Three ALDH High-36 cells and Low-8 cells represent novel gastric CSCs/CICs and non-CSCs/CICs, respectively. ALDH

Sections du résumé

BACKGROUND/AIM OBJECTIVE
Human gastric cancer stem-like cells (CSCs)/cancer-initiating cells can be identified as aldehyde dehydrogenase-high (ALDH
MATERIALS AND METHODS METHODS
Gastric CSCs/CICs were isolated as ALDH
RESULTS RESULTS
Three ALDH
CONCLUSION CONCLUSIONS
High-36 cells and Low-8 cells represent novel gastric CSCs/CICs and non-CSCs/CICs, respectively. ALDH

Identifiants

DOI: 10.21873/anticanres.16989 PMID: 38677758
pubmed: 38677758
pii: 44/5/1877
doi: 10.21873/anticanres.16989
doi:

Substances chimiques

Aldehyde Dehydrogenase 1 Family EC 1.2.1
Retinal Dehydrogenase EC 1.2.1.36
ALDH1A1 protein, human EC 1.2.1.36
Histocompatibility Antigens Class I 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1877-1883

Informations de copyright

Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Tomohide Shirosaki (T)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Noriko Kawai (N)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Yuma Ebihara (Y)

Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Aiko Murai (A)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Terufumi Kubo (T)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Rena Morita (R)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Kenji Murata (K)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Takayuki Kanaseki (T)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Tomohide Tsukahara (T)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Toshiaki Shichinohe (T)

Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Yoshihiko Hirohashi (Y)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan hirohash@sapmed.ac.jp.

Satoshi Hirano (S)

Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Toshihiko Torigoe (T)

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan hirohash@sapmed.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Aldehyde dehydrogenase › Aldehyde dehydrogenase 1 › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T cytotoxiques › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Retinal dehydrogenase › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Phénomènes du système immunitaire › Échappement de la tumeur à la surveillance immunitaire › Aldehyde Dehydrogenese-1 High Cancer Stem-like...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe I › Aldehyde Dehydrogenese-1 High Cancer Stem-like...