Proteolytic stability and aggregation in a key metabolic enzyme of bacteria.

beta-Galactosidase / metabolism Proteolysis Escherichia coli / metabolism Lac Operon Escherichia coli Proteins / metabolism Protein Aggregates Enzyme Stability
lac operon protein aggregation protein degradation ssrA β-galactosidase

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
07 May 2024
Historique:
medline: 29 4 2024
pubmed: 29 4 2024
entrez: 29 4 2024
Statut: ppublish

Résumé

Proteins that are kinetically stable are thought to be less prone to both aggregation and proteolysis. We demonstrate that the classical

Identifiants

DOI: 10.1073/pnas.2301458121 PMID: 38683989
pubmed: 38683989
doi: 10.1073/pnas.2301458121
doi:

Substances chimiques

beta-Galactosidase EC 3.2.1.23
Escherichia coli Proteins 0
Protein Aggregates 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2301458121

Subventions

Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01GM120231
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01GM148703

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Dan Pollack (D)

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003.
ORCID: 0000-0003-4955-1826

Takashi Nozoe (T)

Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan.
Research Center for Complex Systems Biology, The University of Tokyo, Tokyo 153-8902, Japan.
Universal Biology Institute, The University of Tokyo, Tokyo 113-0033, Japan.
ORCID: 0000-0003-2556-6484

Edo Kussell (E)

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003.
Department of Physics, New York University, New York, NY 10003.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Galactosidases › beta-Galactosidase › Proteolytic stability and aggregation in a key...
questionsmedicales.fr › Métabolisme › Protéolyse › Proteolytic stability and aggregation in a key...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Proteolytic stability and aggregation in a key...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Opéron › Opéron lac › Proteolytic stability and aggregation in a key...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Proteolytic stability and aggregation in a key...
questionsmedicales.fr › Structures macromoléculaires › Agrégats de protéines › Proteolytic stability and aggregation in a key...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Stabilité enzymatique › Proteolytic stability and aggregation in a key...