Dual Strategy to Design New Agents Targeting

cathepsin-B-like protease covalent inhibition schistosomiasis structure−activity relationship study

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
30 Apr 2024
Historique:
medline: 30 4 2024
pubmed: 30 4 2024
entrez: 30 4 2024
Statut: aheadofprint

Résumé

In this study, we have identified and optimized two lead structures from an in-house screening, with promising results against the parasitic flatworm

Identifiants

DOI: 10.1021/acsinfecdis.4c00020 PMID: 38686397
pubmed: 38686397
doi: 10.1021/acsinfecdis.4c00020
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Natalie Fuchs (N)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
ORCID: 0000-0001-6404-676X

Robert A Zimmermann (RA)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
ORCID: 0000-0002-5330-9234

Marvin Schwickert (M)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
ORCID: 0000-0002-1385-1416

Annika Gunkel (A)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

Collin Zimmer (C)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

Mergim Meta (M)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
ORCID: 0000-0003-3601-9523

Kevin Schwickert (K)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

Jennifer Keiser (J)

Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.

Cécile Haeberli (C)

Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.

Werner Kiefer (W)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

Tanja Schirmeister (T)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

Classifications MeSH