Germline
5-fluorouracil
CEBPB
cancer biology
chemotherapy
drug resistance
epigenetics
gene regulation
genetics
genomics
human
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 Apr 2024
30 Apr 2024
Historique:
medline:
30
4
2024
pubmed:
30
4
2024
entrez:
30
4
2024
Statut:
epublish
Résumé
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanisms remain elusive. Using a well-defined drug-gene pair, we identified an enhancer region for dihydropyrimidine dehydrogenase (DPD,
Identifiants
pubmed: 38686795
doi: 10.7554/eLife.94075
pii: 94075
doi:
pii:
Substances chimiques
Fluorouracil
U3P01618RT
Dihydrouracil Dehydrogenase (NADP)
EC 1.3.1.2
Antineoplastic Agents
0
Antimetabolites, Antineoplastic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01CA251065
Pays : United States
Informations de copyright
© 2024, Zhang et al.
Déclaration de conflit d'intérêts
TZ, AA, HH, KB, AE, RS, BB, ZT, ZW, DS, RD, CL No competing interests declared, FI Currently an AbbVie employee and receives stocks from the company, SO Reports current research support from Processa Pharmaceuticals, Inc, which are outside of the conduct of this study. Has previously served as an independent consultant for Processa Pharmaceuticals, Inc, in matters not related to this study
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