Tacrolimus's Time Below Therapeutic Range Is Associated With Acute Pancreatic Graft Rejection and the Development of


Journal

Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516

Informations de publication

Date de publication:
2024
Historique:
received: 20 12 2023
accepted: 11 03 2024
medline: 2 5 2024
pubmed: 2 5 2024
entrez: 2 5 2024
Statut: epublish

Résumé

Tacrolimus is pivotal in pancreas transplants but poses challenges in maintaining optimal levels due to recipient differences. This study aimed to explore the utility of time spent below the therapeutic range and intrapatient variability in predicting rejection and

Identifiants

pubmed: 38694489
doi: 10.3389/ti.2024.12591
pii: 12591
pmc: PMC11062183
doi:

Substances chimiques

Tacrolimus WM0HAQ4WNM
Immunosuppressive Agents 0
Isoantibodies 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

12591

Informations de copyright

Copyright © 2024 Rodríguez-Espinosa, Broseta, Montagud-Marrahí, Arana, Ferrer, Cuatrecasas, Garcia-Criado, Amor, Diekmann and Ventura-Aguiar.

Déclaration de conflit d'intérêts

D-RE has received expenditures on travel, hospitality and conferences by Chiesi. PV-A has received expenditures on travel, hospitality and conferences by Chiesi and Astellas. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Diana Rodríguez-Espinosa (D)

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.
Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

José Jesús Broseta (JJ)

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.
Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Enrique Montagud-Marrahí (E)

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.
Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Carolt Arana (C)

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.
Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Joana Ferrer (J)

Department of Hepatobiliopancreatic Surgery and Liver Transplant, Hospital Clínic, Barcelona, Spain.

Miriam Cuatrecasas (M)

Department of Pathology, Hospital Clínic Barcelona, Barcelona, Spain.

Ángeles Garcia-Criado (Á)

Department of Radiology, Hospital Clínic Barcelona, Barcelona, Spain.

Antonio J Amor (AJ)

Diabetes Unit, Department of Endocrinology and Nutrition, Hospital Clínic Barcelona, Barcelona, Spain.

Fritz Diekmann (F)

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.
Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Pedro Ventura-Aguiar (P)

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.
Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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Classifications MeSH