Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry.

Humans Male Middle Aged Female Adult Registries Retrospective Studies Eosinophilia / diagnosis Antibodies, Antineutrophil Cytoplasmic / blood Granulomatosis with Polyangiitis / diagnosis Aged Churg-Strauss Syndrome / diagnosis Peroxidase / immunology Eosinophils / immunology

Journal

Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166

Informations de publication

Date de publication:
2024
Historique:
received: 11 11 2023
revised: 26 03 2024
accepted: 06 04 2024
medline: 3 5 2024
pubmed: 3 5 2024
entrez: 3 5 2024
Statut: epublish

Résumé

To characterize the eosinophilic granulomatosis with polyangiitis (EGPA) population from the POLVAS registry depending on ANCA status and diagnosis onset, including their comparison with the granulomatosis with polyangiitis (GPA) subset with elevated blood eosinophilia (min. 400/ A retrospective analysis of the POLVAS registry. The EGPA group comprised 111 patients. The ANCA-positive subset ( Cardiovascular symptoms were more prevalent in the ANCA-negative subset than in the MPO-ANCA-positive one. Since EGPA and GPE HE share similarities in clinics, diagnostic misleading may result in an inappropriate therapeutic approach. Further studies are needed to optimize their differentiation and tailored therapy, including biologics.

Identifiants

DOI: 10.1155/2024/4283928 PMID: 38699219 PMC: PMC11065486
pubmed: 38699219
doi: 10.1155/2024/4283928
pmc: PMC11065486
doi:

Substances chimiques

Antibodies, Antineutrophil Cytoplasmic 0
Peroxidase EC 1.11.1.7

Types de publication

Journal Article Comparative Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

4283928

Informations de copyright

Copyright © 2024 Anna Drynda et al.

Déclaration de conflit d'intérêts

All authors have declared no conflicts of interest.

Auteurs

Anna Drynda (A)

Students' Scientific Group of Immune Diseases and Hypercoagulation, Jagiellonian University Medical College, Cracow, Poland.
ORCID: 0009-0009-5556-2637

Agnieszka Padjas (A)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Krzysztof Wójcik (K)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Radosław Dziedzic (R)

Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Cracow, Poland.
ORCID: 0000-0003-0321-3557

Grzegorz Biedroń (G)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Katarzyna Wawrzycka-Adamczyk (K)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Anna Włudarczyk (A)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Joanna Wilańska (J)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Jacek Musiał (J)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Zbigniew Zdrojewski (Z)

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland.

Zenobia Czuszyńska (Z)

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland.

Anna Masiak (A)

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland.

Maria Majdan (M)

Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland.

Radosław Jeleniewicz (R)

Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland.

Hanna Augustyniak-Bartosik (H)

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.

Katarzyna Jakuszko (K)

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.

Magdalena Krajewska (M)

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.

Alicja Dębska-Ślizień (A)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Hanna Storoniak (H)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Barbara Bułło-Piontecka (B)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Witold Tłustochowicz (W)

Department of Internal Medicine and Rheumatology, Military Medical Institute, Warsaw, Poland.

Joanna Kur-Zalewska (J)

Department of Internal Medicine and Rheumatology, Military Medical Institute, Warsaw, Poland.

Małgorzata Wisłowska (M)

Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Piotr Głuszko (P)

Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Marta Madej (M)

Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland.

Ewa Jassem (E)

Department of Allergology, Medical University of Gdansk, Gdansk, Poland.

Iwona Damps-Konstańska (I)

Department of Allergology, Medical University of Gdansk, Gdansk, Poland.

Eugeniusz Kucharz (E)

Department of Internal Medicine, Rheumatology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.

Marek Brzosko (M)

Department of Rheumatology, Internal Medicine, Diabetology, Geriatrics and Clinical Immunology with the Gastroenterology Unit, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Marcin Milchert (M)

Department of Rheumatology, Internal Medicine, Diabetology, Geriatrics and Clinical Immunology with the Gastroenterology Unit, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Anna Hawrot-Kawecka (A)

Department of Internal Medicine and Metabolic Diseases, Medical University of Silesia, Katowice, Poland.

Joanna Miłkowska-Dymanowska (J)

Department of Pneumology, Chair of Internal Medicine, Medical University of Lodz, Lodz, Poland.

Paweł Górski (P)

Department of Pneumology, Chair of Internal Medicine, Medical University of Lodz, Lodz, Poland.

Anna Lewandowska-Polak (A)

Department of Rheumatology, Medical University of Lodz, Lodz, Poland.

Joanna Makowska (J)

Department of Rheumatology, Medical University of Lodz, Lodz, Poland.

Joanna Zalewska (J)

Department of Rheumatology and Connective Tissue Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz of the Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Lech Zaręba (L)

Institute of Computer Science, College of Natural Sciences, University of Rzeszow, Rzeszow, Poland.

Stanisława Bazan-Socha (S)

2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.
ORCID: 0000-0001-9634-0963

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Troubles leucocytaires › Éosinophilie › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Anticorps anti-cytoplasme des polynucléaires neutrophiles › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Granulomatose avec polyangéite › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Syndrome de Churg-Strauss › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Myeloperoxidase › Clinical Characteristics of EGPA Patients in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes éosinophiles › Clinical Characteristics of EGPA Patients in...