Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity.
exercise
fasting
lactate
muscle fiber type
neurotrophins
β-hydroxybutyrate
Journal
Function (Oxford, England)
ISSN: 2633-8823
Titre abrégé: Function (Oxf)
Pays: England
ID NLM: 101770668
Informations de publication
Date de publication:
2024
2024
Historique:
received:
15
11
2023
revised:
15
12
2023
accepted:
24
01
2024
medline:
6
5
2024
pubmed:
6
5
2024
entrez:
6
5
2024
Statut:
epublish
Résumé
Exercise promotes brain plasticity partly by stimulating increases in mature brain-derived neurotrophic factor (mBDNF), but the role of the pro-BDNF isoform in the regulation of BDNF metabolism in humans is unknown. We quantified the expression of pro-BDNF and mBDNF in human skeletal muscle and plasma at rest, after acute exercise (+/- lactate infusion), and after fasting. Pro-BDNF and mBDNF were analyzed with immunoblotting, enzyme-linked immunosorbent assay, immunohistochemistry, and quantitative polymerase chain reaction. Pro-BDNF was consistently and clearly detected in skeletal muscle (40-250 pg mg
Identifiants
pubmed: 38706964
doi: 10.1093/function/zqae005
pii: zqae005
pmc: PMC11065112
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
BDNF protein, human
7171WSG8A2
Lactic Acid
33X04XA5AT
Protein Precursors
0
brain-derived neurotrophic factor precursor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
zqae005Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of American Physiological Society.
Déclaration de conflit d'intérêts
None declared.