Trefoil factor 3 can stimulate Th17 cell response in the development of type 2 diabetes mellitus.
Helper T Lymphocyte 17
Inflammation
Trefoil factor 3
Type 2 diabetes mellitus
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 May 2024
06 May 2024
Historique:
received:
09
01
2024
accepted:
23
04
2024
medline:
7
5
2024
pubmed:
7
5
2024
entrez:
6
5
2024
Statut:
epublish
Résumé
This study aims to evaluate the role of trefoil factor 3 (TFF3) peptides in type 2 diabetes mellitus (T2DM) from an inflammatory perspective. The focus was on exploring how TFF3 affects the function of T cells. TFF3 overexpression model was constructed using lentivirus in Jurkat cell lines. We evaluated the impact of TFF3 on the proliferation, apoptosis, and IL-17A levels of Jurkat cells cultured in high glucose. The T2DM model was induced in TFF3 knockout (KO) mice through streptozotocin combined with high-fat diet. The measurements included glucose tolerance, insulin tolerance, inflammation markers, Th17 cell proportion, and pancreatic pathological changes. The T2DM modeling led to splenomegaly in mice, and increased expression of TFF3 in their spleens. Overexpression of TFF3 increased the proportion of IL-17
Identifiants
pubmed: 38710764
doi: 10.1038/s41598-024-60426-7
pii: 10.1038/s41598-024-60426-7
doi:
Substances chimiques
Trefoil Factor-3
0
Interleukin-17
0
Tff3 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10340Subventions
Organisme : the National Natural Science Foundation of China
ID : 82204704
Organisme : Science and Technology Project of Guangzhou
ID : 2024A04J9912
Organisme : Project of Department of Education of Guangdong Province
ID : 2022KQNCX031
Informations de copyright
© 2024. The Author(s).
Références
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