Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression.
Animals
Mice, Knockout
Mice
Humans
Semaphorins
/ metabolism
Cellular Senescence
Human Umbilical Vein Endothelial Cells
/ metabolism
Endothelial Cells
/ metabolism
Aging
/ metabolism
RNA-Binding Proteins
/ metabolism
DNA-Binding Proteins
/ metabolism
Mice, Inbred C57BL
Membrane Glycoproteins
/ metabolism
Endothelium, Vascular
/ metabolism
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
07 May 2024
07 May 2024
Historique:
received:
23
05
2022
accepted:
22
04
2024
medline:
8
5
2024
pubmed:
8
5
2024
entrez:
7
5
2024
Statut:
epublish
Résumé
Age-related diseases pose great challenges to health care systems worldwide. During aging, endothelial senescence increases the risk for cardiovascular disease. Recently, it was described that Phosphatase 1 Nuclear Targeting Subunit (PNUTS) has a central role in cardiomyocyte aging and homeostasis. Here, we determine the role of PNUTS in endothelial cell aging. We confirm that PNUTS is repressed in senescent endothelial cells (ECs). Moreover, PNUTS silencing elicits several of the hallmarks of endothelial aging: senescence, reduced angiogenesis and loss of barrier function. Findings are validate in vivo using endothelial-specific inducible PNUTS-deficient mice (Cdh5-CreERT2;PNUTS
Identifiants
pubmed: 38714838
doi: 10.1038/s42003-024-06230-5
pii: 10.1038/s42003-024-06230-5
doi:
Substances chimiques
Semaphorins
0
SEMA3B protein, human
0
RNA-Binding Proteins
0
DNA-Binding Proteins
0
Membrane Glycoproteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
541Subventions
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research)
ID : Vidi
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 825670
Informations de copyright
© 2024. The Author(s).
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