CSC
Humans
Mouth Neoplasms
/ pathology
Cadherins
/ metabolism
Female
Male
Prognosis
Biomarkers, Tumor
/ metabolism
Middle Aged
Carcinoma, Squamous Cell
/ metabolism
Immunohistochemistry
Aged
Aldehyde Dehydrogenase 1 Family
/ metabolism
Neoplastic Stem Cells
/ metabolism
Receptors, Nerve Growth Factor
/ metabolism
Retinal Dehydrogenase
/ metabolism
Hyaluronan Receptors
/ metabolism
Adult
Lymphatic Metastasis
Nerve Tissue Proteins
/ metabolism
Polycomb Repressive Complex 1
/ metabolism
Cancer stem cells
Digital pathology
Epithelial-mesenchymal transition
Immunohistochemistry
Metastasis
Oral cancer
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 May 2024
08 May 2024
Historique:
received:
30
09
2023
accepted:
26
02
2024
medline:
9
5
2024
pubmed:
9
5
2024
entrez:
8
5
2024
Statut:
epublish
Résumé
Identifying marker combinations for robust prognostic validation in primary tumour compartments remains challenging. We aimed to assess the prognostic significance of CSC markers (ALDH1, CD44, p75NTR, BMI-1) and E-cadherin biomarkers in OSCC. We analysed 94 primary OSCC and 67 metastatic lymph node samples, including central and invasive tumour fronts (ITF), along with clinicopathological data. We observed an increase in ALDH1
Identifiants
pubmed: 38719848
doi: 10.1038/s41598-024-55594-5
pii: 10.1038/s41598-024-55594-5
doi:
Substances chimiques
Cadherins
0
Biomarkers, Tumor
0
Aldehyde Dehydrogenase 1 Family
EC 1.2.1
NGFR protein, human
0
Receptors, Nerve Growth Factor
0
ALDH1A1 protein, human
EC 1.2.1.36
Retinal Dehydrogenase
EC 1.2.1.36
Hyaluronan Receptors
0
CD44 protein, human
0
Nerve Tissue Proteins
0
Polycomb Repressive Complex 1
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10583Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2015/06945-2
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2009/53839-2
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2013/07245-9
Informations de copyright
© 2024. The Author(s).
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