A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 May 2024
09 May 2024
Historique:
received:
04
08
2022
accepted:
16
04
2024
medline:
10
5
2024
pubmed:
10
5
2024
entrez:
9
5
2024
Statut:
epublish
Résumé
By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) in a subset of metaplastic MUC5AC
Identifiants
pubmed: 38724552
doi: 10.1038/s41467-024-48034-5
pii: 10.1038/s41467-024-48034-5
doi:
Substances chimiques
ITLN1 protein, human
0
Interleukin-13
0
Lectins
0
Mucin 5AC
0
GPI-Linked Proteins
0
MUC5AC protein, human
0
IL13 protein, human
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3900Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL135156
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD010443
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128439
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132821
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL107202
Pays : United States
Informations de copyright
© 2024. The Author(s).
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