Clinical status of established MRONJ in oncology patients continuing bone-modifying agents.
Journal
British dental journal
ISSN: 1476-5373
Titre abrégé: Br Dent J
Pays: England
ID NLM: 7513219
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
received:
15
10
2023
accepted:
19
01
2024
revised:
10
01
2024
medline:
11
5
2024
pubmed:
11
5
2024
entrez:
10
5
2024
Statut:
ppublish
Résumé
The continuation of bone-modifying agents (BMAs) in patients with established medication-related osteonecrosis of the jaw (MRONJ) is a common concern among dentists and oncologists. There is little evidence supporting or refuting the continued use of BMAs or drug holidays and their impact on established MRONJ. This paper evaluates the outcome of continued BMAs use on the patient's MRONJ status. A retrospective review of 29 oncology patients undergoing active cancer care for either metastatic disease or multiple myeloma was conducted. Data on demographics, oncological status, BMA history and MRONJ status were collected. In total, 90% of patients were judged to have healed or stable MRONJ while continuing BMAs. Most patients (69%) continued the same BMA regime (three- or four-weekly) that they were on before developing MRONJ. The average number of BMAs doses received after an MRONJ diagnosis was 12 (range 1-48). Three patients (10.3%) were found to have MRONJ progression, with two patients developing new sites of necrosis. This real-world dataset suggests that the majority of MRONJ cases remain stable and will not worsen with the continuation of BMAs.
Identifiants
pubmed: 38730156
doi: 10.1038/s41415-024-7340-9
pii: 10.1038/s41415-024-7340-9
doi:
Substances chimiques
Bone Density Conservation Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
683-687Informations de copyright
© 2024. The Author(s), under exclusive licence to the British Dental Association.
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