Molecularly Imprinted Drug Carrier for Lamotrigine-Design, Synthesis, and Characterization of Physicochemical Parameters.

Lamotrigine / chemistry Drug Carriers / chemistry Molecularly Imprinted Polymers / chemistry Molecular Imprinting / methods Spectroscopy, Fourier Transform Infrared Drug Liberation X-Ray Diffraction Adsorption Hydrogen-Ion Concentration
drug carrier drug delivery lamotrigine magnetic particle molecularly imprinted polymer

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Apr 2024
Historique:
received: 13 03 2024
revised: 16 04 2024
accepted: 18 04 2024
medline: 11 5 2024
pubmed: 11 5 2024
entrez: 11 5 2024
Statut: epublish

Résumé

This study presents the initial attempt at introducing a magnetic molecularly imprinted polymer (MIP) designed specifically for lamotrigine with the purpose of functioning as a drug carrier. First, the composition of the magnetic polymer underwent optimization based on bulk polymer adsorption studies and theoretical analyses. The magnetic MIP was synthesized from itaconic acid and ethylene glycol dimethacrylate exhibiting a drug loading capacity of 3.4 ± 0.9 μg g

Identifiants

DOI: 10.3390/ijms25094605 PMID: 38731823
pubmed: 38731823
pii: ijms25094605
doi: 10.3390/ijms25094605
pii:
doi:

Substances chimiques

Lamotrigine U3H27498KS
Drug Carriers 0
Molecularly Imprinted Polymers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Research Foundation
ID : CSRP200411512596
Organisme : Medical University of Warsaw
ID : FW24/1/F/MBS/N/21
Organisme : Interdisciplinary Centre for Mathematical and Computational Modelling
ID : G68-2

Auteurs

Monika Sobiech (M)

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
ORCID: 0000-0002-5687-2874

Sandile M Khamanga (SM)

Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.
ORCID: 0000-0003-2374-8460

Karol Synoradzki (K)

Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Poznań, Poland.
ORCID: 0000-0002-7732-3284

Tamara J Bednarchuk (TJ)

Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland.

Katarzyna Sikora (K)

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.

Piotr Luliński (P)

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
ORCID: 0000-0001-8421-5225

Joanna Giebułtowicz (J)

Department of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
ORCID: 0000-0002-2567-4453

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Triazines › Lamotrigine › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polymères à empreintes moléculaires › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Empreinte moléculaire › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie IR › Spectroscopie infrarouge à transformée de Fourier › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Phénomènes chimiques › Diffraction des rayons X › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Phénomènes chimiques › Adsorption › Molecularly Imprinted Drug Carrier for...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Molecularly Imprinted Drug Carrier for...